Symposium Dier - de positie van dieren in onze maatschappij : Symposium in het teken van het afscheid van Ferry Leenstra bij Wageningen Livestock Research op dinsdag 17 december 2019

In december 2019 organiseerde Wageningen Livestock Research een symposium om de veranderende positie van dieren, zowel productiedieren, gezelschapsdieren, proefdieren als niet-gehouden dieren, in onze maatschappij te bespreken en te onderzoeken wat dat voor de rol van WUR betekent. In dit rapport zijn de conclusies van dit symposium samengevat.---n December 2019 Wageningen Livestock Research organized a symposium to discuss the altering position of animals, production animals as well as companion animals, laboratory animals and wild animals, in society. This report summarizes the conclusions of the symposium

Psychometrics of the patient-reported outcomes measurement information system measures in hemophilia:the applicability of the pediatric item banks

Background: The use of patient-reported outcomes measures (PROMs) is important in hemophilia care, as it facilitates communication between patients and clinicians and promotes patient-centered care. Currently, a variety of PROMs with insufficient psychometric properties are used. Patient-reported outcomes measurement information system (PROMIS) measures, including Computer Adaptive Tests, were designed to measure generically and more efficiently and, therefore, are an alternative for the existing PROMs. Objectives: To assess the feasibility, measurement properties, and outcomes of 8 PROMIS pediatric measures for boys with hemophilia. Methods: In this multicenter study, boys with hemophilia completed 8 PROMIS measures and 2 legacy instruments. Feasibility was determined by the number of completed items and floor or ceiling effects (percentage of participants that achieved the lowest or highest possible score). Reliability was assessed as the percentage of scores with a SE ≤ 4.5. Construct validity was evaluated by comparing the PROMIS measures with the legacy instruments. Mean PROMIS T-scores were calculated and compared with the Dutch general population. Results: In total, 77 boys with hemophilia participated. Reliability was good for almost all PROMIS measures and legacy instruments. The total number of completed items varied from 49 to 90 for the PROMIS pediatric measures, while the legacy instruments contained 117 to 130 items. Floor and ceiling effects were observed in both the PROMIS measures (0-39.5%) and legacy instruments (0-66.7%), but were higher for the legacy instruments. Conclusions: The PROMIS pediatric measures are feasible to use for boys with hemophilia. With the use of the PROMIS measures in clinical care and research, a step toward worldwide standardization of PROM administration can be taken.</p

Multilaboratory Comparison of Pneumococcal Multiplex Immunoassays Used in lmmunosurveillance of Streptococcus pneumoniae across Europe

Surveillance studies are required to estimate the impact of pneumococcal vaccination in both children and the elderly across Europe. The World Health Organization (WHO) recommends use of enzyme immunoassays (EIAs) as standard methods for immune surveillance of pneumococcal antibodies. However, as levels of antibodies to multiple serotypes are monitored in thousands of samples, a need for a less laborious and more flexible method has evolved. Fluorescent-bead-based multiplex immunoassays (MIAs) are suitable for this purpose. An increasing number of public health and diagnostic laboratories use MIAs, although the method is not standardized and no international quality assessment scheme exists. The EU Pneumo Multiplex Assay Consortium was initiated in 2013 to advance harmonization of MIAs and to create an international quality assessment scheme. In a multilaboratory comparison organized by the consortium, agreement among nine laboratories that used their own optimized MIA was assessed on a panel of 15 reference sera for 13 pneumococcal serotypes with the new WHO standard 007sp. Agreement was assessed in terms of assay accuracy, reproducibility, repeatability, precision, and bias. The results indicate that the evaluated MIAs are robust and reproducible for measurement of vaccine-induced antibody responses. However, some serotype-specific variability in the results was observed in comparisons of polysaccharides from different sources and of different conjugation methods, especially for serotype 4. On the basis of the results, the consortium has contributed to the harmonization of MIA protocols to improve reliability of immune surveillance of Streptococcus pneumoniae

Symposium Dier - de positie van dieren in onze maatschappij : Symposium in het teken van het afscheid van Ferry Leenstra bij Wageningen Livestock Research op dinsdag 17 december 2019

In december 2019 organiseerde Wageningen Livestock Research een symposium om de veranderende positie van dieren, zowel productiedieren, gezelschapsdieren, proefdieren als niet-gehouden dieren, in onze maatschappij te bespreken en te onderzoeken wat dat voor de rol van WUR betekent. In dit rapport zijn de conclusies van dit symposium samengevat.---n December 2019 Wageningen Livestock Research organized a symposium to discuss the altering position of animals, production animals as well as companion animals, laboratory animals and wild animals, in society. This report summarizes the conclusions of the symposium

Integraal sturen op doelen voor duurzame landbouw via KPI’s

Deze notitie is bedoeld als achtergrondstuk voor beleidsmakers, betrokkenen bij experimenteergebieden en andere stakeholders die aan de slag zijn met de ontwikkeling van Kritische Prestatie Indicatoren (KPI’s) voor duurzame kringlooplandbouw. De notitie biedt een gezamenlijk kader voor deze ontwikkeling. Een gezamenlijk kader is belangrijk doordat aan de vergader- en keukentafels verschillende beelden en verwachtingen ontstaan over de ontwikkeling van een KPI-systematiek voor kringlooplandbouw, wat de samenwerking in de weg kan staan. Deze notitie geeft daarom richting aan de verdere ontwikkeling en toepassing van een KPI-systematiek voor kringlooplandbouw