Chronic effects of hydro-alcoholic artemisia absinthium extract on the liver enzymes and tissue changes of adult mal rat

Artemisia absinthium has many pharmacological effects, but toxic effects of it, were seen on nervous system and liver. Therefore, the aim of this study was to evaluate the chronic effects of different doses of Artemisia absinthium extract on the enzymes and histopathological changes of the liver tissue of adult normal male rat. Method and materials: In this experimental study, forty eight male Wistar rats were randomly divided into 6 groups of 8 as follows: Control, sham (recipient of distilled water) and 4 experimental groups that received Artemisia absinthium hydro- alcoholic extract at doses of 125, 250, 500 and 1000 mg/kg intraperitoneally.The data were analyzed using one-way ANOVA and Duncan post hoc tests. P≤0.05 was considered statistically significant. Results: After 8 weeks, doses of 125, 250 and 500 mg/kg could significantly reduce amount of ALT, AST and ALP. Dose of 1000 mg/kg increased ALT, AST and ALP. From the standpoint of histopathological study, doses of 125, 250 and 500 Artemisia absinthium had no significant side effect on liver tissue, but 1000 mg/kg caused destruction of liver cell membranes, enlargement of sinusoidal space, sporadic leukocyte infiltration, Kupffer cells hypertrophy, and vascular congestion.Conclusion: Maximum dose of Artemisia absinthium extract (1000 mg/kg) increased liver enzymes and destroy liver tissues of normal male rats.Keywords: Artemisia Absinthium, Enzymes, Histopathology, Liver, Ra

Prevalence and risk factors of complication of endotracheal extubation in teaching hospitals affiliated with Jahrom University of medical science

Endotracheal intubation is to maintain a safe open airway to prevent pulmonary aspiration by administrating general anesthesia. Endotracheal tube, as a foreign body, can stimulate the patients’ airway during the emergence from general anesthesia and cause various reactions and complications immediately or within a multi-day delay.The present study intended to determine the prevalence and associated risk factors of the complications of endotracheal extubation (removal of endotracheal tube / ETT) within 24 hrs. since the surgery. To this end, a descriptive research was conducted on 200 adult candidates for elective and emergency surgery of endotracheal intubation by administrating general anesthesia. Data about the intended associated risk factors and complications were respectively collected in operating room (OR) and within 24 hrs. since surgery and were recorded in the questionnaire. The results indicated that the prevalent complications were sore throat (%21), cough (%12.5) and hoarseness (%15.5). There was not any case of dysphagia and bloody sputum (blood-streaked expectorant). Also, there was a significant relationship between sore throat and the type of surgery (P˂0.001). On the other hand, there was not any statistically significant relationship between sore throat and other associated risk factors (sex, age, weight, type of surgery and size of endotracheal tube). Likewise, not any significant relationship was observed between cough, hoarseness and the intended risk factors. To conclude, the present study found that the type of surgery has a significant effect on the incidence of sore throat within 24 hrs. since the surgical operation; thus, raising awareness of these risk factors and taking proper actions, particularly during intubation, can reduce the incidence of complications, in particular sore throat, and improve patients’ satisfaction.Keywords: General Anesthesia; Intubation; Complication

Comparison of complications of spinal and general anesthasia in percutaneous kidney stone removal

While the complications of spinal anesthesia are much less than general anesthesia, percutaneous nephrolithotomy (PCNL) is still performed under general anesthesia in most centers. Therefore, in this study spinal anesthesia is compared with general anesthesia in patients undergoing PCNL. This research was a double-blind clinical trial study which was conducted on 130 patients with inclusion criteria. Patients were nonrandomly assigned into two general anesthesia (n=65) and spinal anesthesia (n=65) groups and underwent PCNL surgery.In group A, patients were given intravenously midazolam (2 mg), fentanyl (100 μg), atracurium (0.5 mg/kg), propofol (2 mg/kg) and morphine (10 mg) and then were incubated. In group B, Marcaine 0.5% (15 mg) was injected into the L3-L4 or L4-L5 lumbar spinal space in a sitting position. Patient’s blood pressure was measured and recorded at various times and in recovery as well as in the surgery room. Intra-operative bleeding, pain in the surgery area, nausea and vomiting, shortness of breath and sore throat were recorded for the two groups in the ward and during hospitalization.Changes of blood pressure were the same in both groups. In the general anesthesia group, intra-operative bleeding, pain at the site of the surgery, nausea and vomiting, shortness of breath and sore throat and duration of hospitalization were significantly higher. Changes in other tests were equal in both groups. Spinal anesthesia might be a safer method than general anesthesia for PCNL surgery.Keywords: Complication, Spinal Anesthesia, General Anesthesia, Kidney Stone Removal, Percutaneou

The knowledge and the use of psychological skills of anger management skills at the bedside by the physicians and nurses of Jahrom University of Medical Sciences in 2013

Although all individuals could be exposed to the outburst of anger, a group of them are more at risk than others because of the nature of their work and responsibilities, that the physicians and nurses are placed in this group. In the field of psychology, different skills such as social protection systems, problem-solving skills, self-relaxation system, use of humor skills and communication and negotiation skills have been proposed to control anger. Given the importance of anger management in the prevention of job violence in the health environment and its impact on psychological health of psychiatrists and nurses and also the lack of information and research on the topic, this study aimed to study the knowledge and the use of psychological skills of anger management at the bedside by the physicians and nurses of Jahrom University of Medical Sciences.Methodology: This study is a cross-sectional and descriptive research, its studied sample included 259 general practitioners, specialists and nurses working in two general hospitals affiliated to Jahrom University of Medical Sciences. They were included in the study by the census method. The data was collected by the self-report method and two researcher-made questionnaires: a questionnaire of the knowledge of the psychological skills of anger management and a questionnaire of the use of anger management skills at the bedside and their validity (face and content) and reliability were examined before performing the research. Data analysis was performed with descriptive statistics (mean, frequency, percentage) using SPSS software.Results: The mean of the knowledge of the physicians and nurses of Jahrom University of Medical Sciences from the psychological skills of anger management was 30.2 (standard deviation is equal to 1.53) that based on the classification of the scores of related questionnaire, it was at a good level. Also, the results showed that the mean of the use of psychological skills of anger management at the bedside by the physicians and nurses working in Jahrom University of Medical Sciences was 39.54 (standard deviation is equal to 1.28) that based on the classification of the scores of related questionnaire, it was at a good level.Conclusion: According to the results, the knowledge and the use of psychological skills of anger management skills at the bedside by the physicians and nurses of Jahrom University of Medical Sciences were at the desired level, however, it is proposed to use other evaluation and assessment methods which have no limitations of self-report method in future studies.Keywords: anger management skill, nurses, physician

An orthorhombic polymorph of 2-(1,3-benzothiazol-2-yl)-6-ethoxyphenol.

In the title molecule, C15H13NO2S, an intramolecular O-H...N hydrogen bond forms an S(6) ring motif. The benzothiazole ring system and the benzene ring form a dihedral angle of 8.9 (3) Å. In the crystal, molecules are linked by weak C-H...O hydrogen bonds, forming chains along the b axis. In addition, [pi]-[pi] interactions [centroid-centroid distances = 3.772 (4) and 3.879 (4) Å] are observed

Effect of exercise on sex-hormone in rats with polycystic ovary syndrome

Introduction: Weight gain and fat accumulation are the risk factors which lead to polycystic ovary syndrome. The aim of this study was to examine the effect of exercise intensity on sexual hormone changes in rats with polycystic ovary syndrome. Materials and Methods: 40 female Wistar rats (180±20mg) with 2 to 3 consecutive estrous cycles during12 to 14 days were selected. The first two groups were divided into control (n=30) and polycystic (n=30) that got sick by estradiol valerate injection after 60 days. The polycystic groups were divided into three groups of observer (n=30), experiment group1 (low-intensity exercise (n=30)) and experiment group 2 (moderate intensity exercise (n=30)). Exercises were performed in 6 sessions of 60 minutes per week for 8 weeks. The mice were anesthetized by injection of 5 ml of blood directly from the heart and the blood factors were measured through Elisa; ANOVA and LSD samples were used for normal distributions and Kruskal-Wallis test for analysis of data that were not normally distributed. Results: Concentrations of FSH in experiment group1increased significantly compared to the control and observer groups. Also, free testosterone was significantly higher as compared to the observer group. FSH concentration in group 2 was higher as compared to the control and observer groups, and changes to LH, estrogen and androstenedion were not significant compared to the control group despite their increase. Conclusion: According to weight changes and sexual hormones (FSH and Androstenedion) exercise, especially with low intensity, may improve the symptoms of polycystic ovary syndrome