Legalizing Corporate Political Speech: How Citizens United Laid the Groundwork for Corporations\u27 Right to Political Speech

The right to political speech is essential for democracy, but should corporations have the same rights as individual persons? In this presentation, Prof. Sebold explains how the US Supreme Court ruling in Citizens United determined that political speech extends to corporations and what that ruling may imply for US politics

Legalizing Corporate Political Speech: How Citizens United Laid the Groundwork for Corporations\u27 Right to Political Speech

The right to political speech is essential for democracy, but should corporations have the same rights as individual persons? In this presentation, Prof. Sebold explains how the US Supreme Court ruling in Citizens United determined that political speech extends to corporations and what that ruling may imply for US politics

How the Social Context of Bill Clinton\u27s Childhood Shaped his Personality: Using Oral History Interviews of his Childhood Peers and Relatives

Since individual personality plays an important role in presidential decision-making (Barber, 1972), then understanding the setting that impacted the personality is an important component in any understanding of a president\u27s personality. This study seeks to understand the setting that shaped the personality of William Jefferson Clinton. This case study was selected for two reasons: (1) there is a plethora of descriptive psycho-biographies of Clinton (Maraniss, 1995, Renshon 1996b, Post, 2006) and (2) there are oral history interviews from individuals who were part of Clinton\u27s familial and childhood peer networks. The interviews used for this study are part of the Clinton History Project, a joint oral history study by the University of Arkansas and The Miller Center at the University of Virginia

The Effects of the Bi-Partisan Campaign Reform Act on the Process of The Campaign Finance in the Presidential Nomination Process

The Bipartisan Campaign Reform Act increased the individual donor limit to $2,000 per candidate per election and indexed the limit for inflation every two years. The primary research question guiding this study is how has the increase in the donor limit affected donor behavior. Answering this question should allow a determination to be made about how donors have responded to the increased donor limit. Understanding how donors responded to the doubled limit is important because it provides evidence on the intersection of wealth inequality and political influence. To answer the research question this study considers how the increased donor limit has changed patterns of participation among donors. The focus is on the preprimary period of the presidential race because it is the most important period to campaign fundraising and the stage that provides the sharpest control of several important political variables given no contest is held in this period and most candidates enter in this stage but few drop out before the start of the primary and there is usually no clear frontrunner. The evaluation covers the 2000 election, representing one period before the increase went into effect, and elections of 2004, 2008, and 2012, representing three periods after the increase went into effect. Descriptive and analytic statistics are used to determine if the increased limit is leading to a distortion in the distribution of donations and widening the gap between the bottom and top donors and states. The findings of this study should provide important information about how the donors responded to the law

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Multicenter Research Data of Epilepsy Management in Patients With Sturge-Weber Syndrome

Background: Epilepsy in typical Sturge-Weber syndrome (SWS) is common, and many questions remain regarding the treatment outcomes. We analyzed a large multicenter database with focus on neurological drug treatment in different demographic and SWS characteristic groups. Methods: A total of 268 patients with brain involvement and a history of seizures were selected from a research data registry generated from a multicenter cross-sectional questionnaire. We examined associations between medication use and binary variables such as sex, ethnicity, and brain, skin, and eye involvement laterality. We analyzed group differences in mean number of antiseizure medications and age at diagnosis, enrollment, and seizure onset and examined differences in median SWS neurological scores in groups of interest. Results: The most frequently used medications were levetiracetam (48.1%), low-dose aspirin (44.8%), oxcarbazepine (39.9%), and phenobarbital (14.9%). Lamotrigine was more frequently used in adults than in children (P = 0.001). History of neurosurgery was associated with no current antiseizure medication use (P = 0.001), whereas bilateral brain involvement and family history of seizures were associated with using a higher number of antiseizure medications (P = 0.002, P = 0.027, respectively). Subjects with bilateral brain involvement and early seizure onset were associated with using a higher number of antiseizure medications (P = 0.002) and phenobarbital use (0.003). Conclusions: Levetiracetam, low-dose aspirin, and oxcarbazepine were the most frequently used medications. More severely affected patients were frequently on a greater number of antiseizure medications. Surgery for epilepsy was associated with the ability to discontinue antiseizure medication. Longitudinal studies are needed to further investigate medication use in patients with SWS