3 research outputs found
ΑΙ ΔΙ' ΑΕΡΟΣ ΕΜΒΟΛΑΙ ΤΩΝ ΣΤΕΦΑΝΙΑΙΩΝ ΚΑΤΑ ΤΑΣ ΚΑΡΔΙΟΧΕΙΡΟΥΡΓΙΚΑΣ ΕΠΕΜΒΑΣΕΙΣ : ΠΕΙΡΑΜΑΤΙΚΗ ΕΡΓΑΣΙΑ
Terazosin treatment suppresses basic fibroblast growth factor expression in the rat ventral prostate
Purpose: Alpha1-adrenergic receptor antagonists may not act solely on smooth muscle contractility. We evaluated the in vivo effect of the alpha1 blocker, terazosin, on the expression of basic fibroblast growth factor (bFGF) in the rat ventral prostate.
Methods: Wistar rats were treated with terazosin (1.2 mg/kg body weight, po, every second day) for 120 days. The expression of bFGF was assessed immuno-histochemically in tissue sections and by Western blotting in whole tissue preparations.
Results: Terazosin treatment did not affect prostate weight or histomorphology. In the control group, epithelial and stromal cells demonstrated positive staining for the anti-bFGF antibody. In contrast, the same staining in terazosin-treated specimens was either absent or extremely weak. An analogous difference was observed among the corresponding immunoblots.
Conclusions: These findings implicate the reduction of bFGF expression by terazosin as a potential additional molecular mechanism of its action that may include alterations in peptide growth factor mediated prostate homeostasis
Laparoscopic vs. open abdominal surgery in male pigs: Marked differences in cortisol and catecholamine response depending on the size of surgical incision
OBJECTIVE: Minimally invasive operations, such as laparoscopic
cholecystectomy and adrenalectomy, result in a more rapid recovery of
normal function, less physiological disturbances and less stress to the
organism than similar open operations. The purpose of this study was to
determine the stress response associated with minimally invasive
abdominal surgery compared to conventional small or large incision
laparotomy. METHODS: We compared the responses of the stress hormones
cortisol and the catecholamines adrenaline and noradrenaline to elective
conventional and laparoscopic cholecystectomy and unilateral
adrenalectomy in male pigs. Blood samples were taken from all animals at
the same time, one day before surgery, at the beginning of the
operation, every 15 minutes during surgery and on the first
postoperative morning. RESULTS: Plasma adrenaline and noradrenaline
concentrations were significantly lower in both cholecystectomies
(p<0.05) and adrenalectomies (p<0.01) during laparoscopic than during
open surgery. Plasma cortisol levels were significantly lower in
laparoscopic than in open adrenalectomies both during surgery and on
postoperative day one (p<0.05), while no major differences in cortisol
levels were observed between laparoscopic and open cholecystectomies.
Thus, the stress-related benefit of laparoscopic surgery depended on the
size of the surgical incision in the conventional operation. CONCLUSION:
Laparoscopic surgery was associated with less surgical stress than open
surgery and this difference was accentuated as the surgical abdominal
wall trauma increased