Activities Undertaken toward Individuals Who Have Been in Contact with Ebola Fever Patient

Significant aspect in the provision of anti-epidemic readiness for Ebola fever importation into the Russian Federation is to determine the scope of measures to be undertaken toward individuals who have been in contact with index case. Analyzed have been the published data on the imported case records resultant in the secondary transmission of the disease; measures, performed in relation to contact persons in non-endemic countries; possible mechanisms of transmission; presence of virus in biological material from an infected individual; risk of exposure to virus onboard the aircraft. Based on the results of the analysis of publications, WHO, CDC and Rospotrebnadzor recommendations, with due consideration of the current regulations, put forward is an approximate procedure for individuals who have been in contact with EVD case onboard the plane, including transportation of persons, exposed to the increased risk of infection into a specialized hospital

The analysis of detectability of the infectious agent at nephrolithiasis treatment

The purpose of this work is monitoring of a kind and structure of microflora at sick of urolithic patients in the presence of chronic calculous pyelonephritis from 2006 to 2009, and also an estimation of dependence of revealing of the infectious agent from the size of concrement. The retrospective analysis of revealing of the infectious agent at 1132 patients of a nephrolithiasis at a stage of preparation for treatment by a method remote and contact lithotripsies concerning a stone of a kidney in the size to 1.5 sm, a stone in the size K,1 - КЗ is carried out, an ureteral stone in the size from 0.7 to 1.5 sm. Direct dependence of revealing of microflora on the size конкремента and change of a kind and microflora structure for the investigated period speaks about necessity of constant monitoring for a choice of adequate antibacterial therapy.Целью данной работы является мониторинг вида и состава микрофлоры у больных мочекаменной болезнью при наличии хронического калькулезного пиелонефрита за период с 2006 по 2009г.г., а также оценка зависимости выявления инфекционного агента от размера конкремента. Проведен ретроспективный анализ выявления инфекционного агента у 1132 больных нефролитиазом на этапе подготовки к лечению методом дистанционной и контактной литотрипсии, а также перкутанной нефролитолапаксии по поводу камня почки размером до 1.5 см, коралловидного камня размером К1 - КЗ, камня мочеточника размером от 0.7 до 1.5 см. Прямая зависимость выявления микрофлоры от размера конкремента и изменение вида и состава микрофлоры за исследуемый период говорит о необходимости постоянного мониторинга для выбора адекватной антибактериальной терапии

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity, which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein-coupled receptors (GPCRs). Here, we uncover an alternate paradigm of GPCR-mediated adipose thermogenesis through the constitutively active receptor, GPR3. We show that the N terminus of GPR3 confers intrinsic signaling activity, resulting in continuous Gs-coupling and cAMP production without an exogenous ligand. Thus, transcriptional induction of Gpr3 represents the regulatory parallel to ligand-binding of conventional GPCRs. Consequently, increasing Gpr3 expression in thermogenic adipocytes is alone sufficient to drive energy expenditure and counteract metabolic disease in mice. Gpr3 transcription is cold-stimulated by a lipolytic signal, and dietary fat potentiates GPR3-dependent thermogenesis to amplify the response to caloric excess. Moreover, we find GPR3 to be an essential, adrenergic-independent regulator of human brown adipocytes. Taken together, our findings reveal a noncanonical mechanism of GPCR control and thermogenic activation through the lipolysis-induced expression of constitutively active GPR3

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity, which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein-coupled receptors (GPCRs). Here, we uncover an alternate paradigm of GPCR-mediated adipose thermogenesis through the constitutively active receptor, GPR3. We show that the N terminus of GPR3 confers intrinsic signaling activity, resulting in continuous Gs-coupling and cAMP production without an exogenous ligand. Thus, transcriptional induction of Gpr3 represents the regulatory parallel to ligand-binding of conventional GPCRs. Consequently, increasing Gpr3 expression in thermogenic adipocytes is alone sufficient to drive energy expenditure and counteract metabolic disease in mice. Gpr3 transcription is cold-stimulated by a lipolytic signal, and dietary fat potentiates GPR3-dependent thermogenesis to amplify the response to caloric excess. Moreover, we find GPR3 to be an essential, adrenergic-independent regulator of human brown adipocytes. Taken together, our findings reveal a noncanonical mechanism of GPCR control and thermogenic activation through the lipolysis-induced expression of constitutively active GPR3.ISSN:0092-8674ISSN:1097-417

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

COMPARATIVE ANALYSIS OF STUDENTS' MOTIVATION IN RUSSIA AND CHINA

The article is devoted to the study of educational motivation of students in Russia and China

ON THE “TUNING RUSSIA” PROJECT

This paper is the first one from the coming soon articles with a description of the results and findings of the project “Tuning of educational structures”. The article highlights the main goals and results of the project “Tuning Russia” conducted in Russia in the period of 2010–2013. Special attention is paid to the basic approaches of the drafting the Reference points of the educational programs in different subject areas. Some findings from the survey of the opinion of academy, alumni, students and employers on the importance and achieved level of the professional competencies in Economics are given. The paper describes several kinds of activities to be done by the Tuning centers were established in 13 Russian universities participated in the project “Tuning Russia”