The links among action-control beliefs, intellective skill, and school performance in Japanese, US, and German school children

We compared the relationships among action-control beliefs, intellective skill, and actual school performance in samples of children from Tokyo (eta = 817, grades 2-6), Los Angeles (eta = 657), and West Berlin (n = 517). Although these samples have been utilised in other comparative studies we have conducted, the role and function of intellective skill, as measured by the Raven Progressive Matrices, has not before been examined. The results of our analyses predicting school performance from the action-control beliefs and the Raven scores were quite revealing. The amount of variance in actual school performance that was shared with (1) the children's action-control beliefs and (2) their Raven scores was very high in West Berlin (86%) and Tokyo (73%), but very low in Los Angeles (37%). These outcomes strengthen arguments that the comparatively high levels of personal agency, but low correlations with performance, are distinctive characteristics of US socioeducational contexts

Aging and Wisdom: Culture Matters

People from different cultures vary in the ways they approach social conflicts, with Japanese being more motivated to maintain interpersonal harmony and avoid conflicts than Americans are. Such cultural differences have developmental consequences for reasoning about social conflict. In the study reported here, we interviewed random samples of Americans from the Midwest United States and Japanese from the larger Tokyo area about their reactions to stories of intergroup and interpersonal conflicts. Responses showed that wisdom (e.g., recognition of multiple perspectives, the limits of personal knowledge, and the importance of compromise) increased with increasing age among Americans, but older age was not associated with wiser responses among Japanese. Younger and middle-aged Japanese showed greater use of wise-reasoning strategies than younger and middle-aged Americans did. This cultural difference was weaker for older participants’ reactions to interpersonal conflicts and was actually reversed for intergroup conflicts. This research has important implications for the study of aging, cultural psychology, and wisdom.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Combining Carbon-Ion Irradiation and PARP Inhibitor, Olaparib Efficiently Kills BRCA1-Mutated Triple-Negative Breast Cancer Cells

BACKGROUND: Triple-negative breast cancer (TNBC) exhibits poor prognosis due to the lack of targets for hormonal or antibody-based therapies, thereby leading to limited success in the treatment of this cancer subtype. Poly (ADP-ribose) polymerase 1 (PARP1) is a critical factor for DNA repair, and using PARP inhibitor (PARPi) is one of the promising treatments for BRCA-mutated (BRCA mut) tumors where homologous recombination repair is impaired due to BRCA1 mutation. Carbon ion (C-ion) radiotherapy effectively induces DNA damages in cancer cells. Thus, the combination of C-ion radiation with PARPi would be an attractive treatment for BRCA mut TNBC, wherein DNA repair systems can be severely impaired on account of the BRCA mutation. Till date, the effectiveness of C-ion radiation with PARPi in BRCA mut TNBC cell killing remains unknown. PURPOSE: Triple-negative breast cancer cell lines carrying either wild type BRCA1, BRCA wt, (MDA-MB-231), or the BRCA1 mutation (HCC1937) were used, and the effectiveness of PARPi, olaparib, combined with C-ion beam or the conventional radiation, or X-ray, on TNBC cell killing were investigated. METHODS: First, effective concentrations of olaparib for BRCA mut (HCC1937) cell killing were identified. Using these concentrations of olaparib, we then investigated their radio-sensitizing effects by examining the surviving fraction of MDA-MB-231 and HCC1937 upon X-ray or C-ion irradiation. In addition, the number of γH2AX (DSB marker) positive cells as well as their expression levels were determined by immunohistochemistry, and results were compared between X-ray irradiated or C-ion irradiated cells. Furthermore, PARP activities in these cells were also observed by performing immunohistochemistry staining for poly (ADP-ribose) polymer (marker for PARP activity), and their expression differences were determined. RESULTS: Treatment of cells with 25 nM olaparib enhanced radio-sensitivity of X-ray irradiated HCC1937, whereas lower dose (5 nM) olaparib showed drastic effects on increasing radio-sensitivity of C-ion irradiated HCC1937. Similar effect was not observed in MDA-MB-231, not possessing the BRCA1 mutation. Results of immunohistochemistry showed that X-ray or C-ion irradiation induced similar number of γH2AX-positive HCC1937 cells, but these induction levels were higher in C-ion irradiated HCC1937 with increased PARP activity compared to that of X-ray irradiated HCC1937. Elevated induction of DSB in C-ion irradiated HCC937 may fully activate DSB repair pathways leading to downstream activation of PARP, subsequently enhancing the effectiveness of PARPi, olaparib, with lower doses of olaparib exerting noticeable effects in cell killing of C-ion irradiated HCC1937. CONCLUSIONS: From this study, we demonstrate that C-ion irradiation can exert significant DSB in BRCA mut TNBC, HCC1937, with high PARP activation. Thus, PARPi, olaparib, would be a promising candidate as a radio-sensitizer for BRCA mut TNBC treatment, especially for C-ion radiotherapy

Cultural affordances and emotional experience: Socially engaging and disengaging emotions in Japan and the United States

The authors hypothesized that whereas Japanese culture encourages socially engaging emotions (e.g., friendly feelings and guilt), North American culture fosters socially disengaging emotions (e.g., pride and anger). In two cross-cultural studies, the authors measured engaging and disengaging emotions repeatedly over different social situations and found support for this hypothesis. As predicted, Japanese showed a pervasive tendency to reportedly experience engaging emotions more strongly than they experienced disengaging emotions, but Americans showed a reversed tendency. Moreover, as also predicted, Japanese subjective well-being (i.e., the experience of general positive feelings) was more closely associated with the experience of engaging positive emotions than with that of disengaging emotions. Americans tended to show the reversed pattern. The established cultural differences in the patterns of emotion suggest the consistent and systematic cultural shaping of emotion over time. (PsycINFO Database Record (c) 2008 APA, all rights reserved)status: publishe

Collective and personal processes in regulating emotions: Emotion and self in Japan and the US

According to a dual process model of emotion regulation, a network of prac­tices and public meanings of culture render the experience of certain emo­tions far more likely than the experience of certain other emotions. Moreover, these practices and meanings reinforce, either positively or negatively, certain emotions more than certain others. These collective-level processes of emo­tion regulation give rise to a number of spontaneous emotions, which may in turn be deliberately and optionally controlled by personal regulatory strate­gies. Available evidence for the model was reviewed to show that whereas socially disengaging emotions such as pride and anger are strongly afforded and reinforced in North America, socially engaging emotions such as friendly feelings and shame are strongly afforded and reinforced in Japan. Implications for cultural psychological research on emotion are discussed.The main goal of this volume is to present, in an integrated framework, the newest, most contemporary perspectives on emotion regulation. The book includes empirically-grounded work and theories that are central to our understanding of the processes that constitute emotion regulation and their consequences. This volume has several secondary aims, as well. One is to highlight several newer subareas in the domain of emotion regulation that hold much promise, such as the relationship between psychopathology and emotion regulation. The book also presents data and theory that have applied value that may be useful for people working in such fields as communication, psychotherapy, and counseling. Finally, the volume gathers contributions across a variety of subfields and includes authors working not just in North America but in other areas of the world. To help achieve these goals, the volume has been organized to begin with the presentation of the most molecular aspects of emotion regulation and to end with the most molar ones. It comprises four parts, each integrating different lines of research from related domains. Part I is devoted to basic processes in emotion regulation, such as neurological, physiological or cognitive processes; part II examines the interplays between emotion regulation and individual regulation; part III presents work on individual differences and developmental processes in emotion regulation; and part IV examines the social functions and constraints of emotion regulation.status: publishe

Defending honour, keeping face: Interpersonal affordances of anger and shame in Turkey and Japan

In the present study, we tested the idea that emotions are afforded to the extent that they benefit central cultural concerns. We predicted that emotions that are beneficial for the Turkish concern for defending honour (both anger and shame) are afforded frequently in Turkey, whereas emotions that are beneficial for the Japanese concern for keeping face (shame but not anger) are afforded frequently in Japan. N = 563 students from Turkey and Japan indicated how frequently people in their culture experience a range of interpersonal anger and shame situations, and how intense their emotions would be. As predicted, participants perceived emotional interactions to occur frequently to the extent that they elicited culturally beneficial emotions. Moreover, the affordance of culturally beneficial emotions differed in predictable ways not only between cultures but also within cultures between situations with close vs. distant others and male vs. female protagonists.peerreview_statement: The publishing and review policy for this title is described in its Aims & Scope. aims_and_scope_url: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=pcem20status: publishe

Fitting in or sticking together: The prevalence and adaptivity of conformity, relatedness, and autonomy in Japan and Turkey

In this research, we compare two forms of interdependent agency. Whereas all interdependent cultures emphasize interpersonal connectedness, we suggest that the nature of this connection may differ between face and honor cultures. In a large survey, with 163 Japanese and 172 Turkish students, we tested the idea that, consistent with the concern for face, Japanese interdependence emphasizes conformity, i.e., fitting in, whereas, consistent with the concern for honor, Turkish interdependence stresses relatedness, i.e., sticking together. The results confirmed these hypotheses: Japanese described their agency more in terms of conformity than Turks, whereas Turks described their agency more in terms of relatedness. Moreover, relational well-being was predicted by conformity in the Japanese group and by relatedness in the Turkish group. Autonomy was also important for both samples, and it predicted personal well-being. Results suggest that a multi-dimensional approach to interdependent agency is needed to distinguish meaningfully between different interdependent cultures .status: publishe