223 research outputs found
Worldline Casting of the Stochastic Vacuum Model and Non-Perturbative Properties of QCD: General Formalism and Applications
The Stochastic Vacuum Model for QCD, proposed by Dosch and Simonov, is fused
with a Worldline casting of the underlying theory, i.e. QCD. Important,
non-perturbative features of the model are studied. In particular,
contributions associated with the spin-field interaction are calculated and
both the validity of the loop equations and of the Bianchi identity are
explicitly demonstrated. As an application, a simulated meson-meson scattering
problem is studied in the Regge kinematical regime. The process is modeled in
terms of the "helicoidal" Wilson contour along the lines introduced by Janik
and Peschanski in a related study based on a AdS/CFT-type approach. Working
strictly in the framework of the Stochastic Vacuum Model and in a semiclassical
approximation scheme the Regge behavior for the Scattering amplitude is
demonstrated. Going beyond this approximation, the contribution resulting from
boundary fluctuation of the Wilson loop contour is also estimated.Comment: 37 pages, 1 figure. Final version to appear in Phys.Rev.
Worldline Approach to Forward and Fixed Angle fermion-fermion Scattering in Yang-Mills Theories at High Energies
Worldline techniques are employed to study the general behaviour of the
fermion-fermion collision amplitude at very high energies in a non-abelian
gauge field theory for the forward and fixed angle scattering cases. A central
objective of this work is to demonstrate the simplicity by which the worldline
methodology isolates that sector of the full theory which carries the soft
physics, relevant to each process. Anomalous dimensions pertaining to a given
soft sector are identified and subseuently used to facilitate the
renormalization group running of the respective four point functions. Gluon
reggeization is achieved for forward, while Sudakov suppression is established
for fixed angle scattering.Comment: 28 pages, 10 figures in three file
Cytolytic T-cell response against Epstein-Barr virus in lung cancer patients and healthy subjects
<p>Abstract</p> <p>Background</p> <p>This study aimed to examine whether EBV seropositive patients with lung cancer have an altered virus-specific CTL response, as compared to age-matched healthy controls and whether any variation in this response could be attributed to senescence.</p> <p>Methods</p> <p>Peripheral blood mononuclear cells from lung cancer patients, age-matched and younger healthy individuals were used to measure EBV-specific CTLs after in vitro amplification with the GLCTLVAML and RYSIFFDYM peptides followed by HLA-multimer staining.</p> <p>Results</p> <p>Lung cancer patients and aged-matched controls had significantly lesser EBV-specific CTL than younger healthy individuals. Multimer positive populations from either group did not differ with respect to the percentage of multimer positive CTLs and the intensity of multimer binding.</p> <p>Conclusions</p> <p>This study provides evidence that patients with lung cancer exhibit an EBV-specific CTL response equivalent to that of age-matched healthy counterparts. These data warrant the examination of whether young individuals have a more robust anti-tumor response, as is the case with the anti-EBV response.</p
2OACTIVATION OF T CELLS UPON TREATMENT WITH BISPECIFIC ANTIBODIES CORRELATES WITH THE EXPRESSION OF CO-INHIBITORY RECEPTORS ON TUMOR-INFILTRATING LYMPHOCYTES IN HUMAN LUNG CANCER
Introduction: T cell bispecific antibodies (TCB) are designed to recruit and simultaneously activate T cells against target cells such as tumor cells expressing a particular surface antigen. However, it is currently unknown how immuno-modulatory mechanisms active in the tumor microenvironment such as the expression of T cell co-inhibitory receptors may influence the therapeutic effect of TCBs. Methods: We performed a comprehensive phenotypic analysis of tumor infiltrating immune cells from lung carcinoma digests by multicolour flow cytometry. In particular, expression of T cell co-inhibitory and -stimulatory receptors was analyzed. Tumor digests were treated with catumaxomab, a TCB directed against CD3 and EpCAM. T cell activation and effector functions were assessed upon exposure to catumaxomab. Results: CD8+ T cells in lung carcinoma showed a broad heterogeneity in expression of the T cell co-inhibitory receptors PD-1, Tim-3, CTLA-4, Lag-3 and BTLA. Tumor stage and nodal status correlated with number and intensity of expressed receptors. Upon exposure to catumaxomab, a considerable heterogeneity in T cell activation among different tumors was observed. Of note, T cells expressing high levels and multiple co-inhibitory receptors were more impaired in their activation and effector functions after treatment with catumaxomab indicating a higher level of exhaustion. In a further analysis of CD8+ TIL subsets we found that BTLA+ T cells expressed more additional inhibitory receptors than all other subsets, namely PD-1, Tim-3, CTLA-4 and Lag-3, whereas only a small part of PD-1+ T cells expressed another receptor. Tim-3+ T cells usually co-expressed PD-1, but multiple receptors were found only on a low number of cells. Conclusion: In summary, our data suggest that the activity of TCBs is largely affected by the expression of T cell co-inhibitory receptors on tumor-infiltrating immune cells. Furthermore, these data provide a clinical rationale for combining bispecific antibodies with compounds which antagonize T cell exhaustion. Disclosure: D. Thommen, J. Schreiner, P. Herzig, P. Mueller and A. Zippelius: received research funding from Roche Glycart; V. Karanikas: is employed by Roche Glycart. All other authors have declared no conflicts of interes
Gauge (non-)invariant Green functions of Dirac fermions coupled to gauge fields
We develop a unified approach to both infrared and ultraviolet asymptotics of
the fermion Green functions in the condensed matter systems that allow for an
effective description in the framework of the Quantum Electrodynamics. By
applying a path integral representation to the previously suggested form of the
physical electron propagator we demonstrate that in the massless case this
gauge invariant function features a "stronger-than-a-pole" branch-cut
singularity instead of the conjectured Luttinger-like behavior. The obtained
results alert one to the possibility that construction of physically relevant
amplitudes in the effective gauge theories might prove more complex than
previously thought
Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835]
INTRODUCTION: Mucin 1 (MUC1) is a high molecular weight glycoprotein overexpressed on adenocarcinoma cells and is a target for immunotherapy protocols. To date, clinical trials against MUC1 have included advanced cancer patients. Herein, we report a trial using early stage breast cancer patients and injection of oxidized mannan-MUC1. METHOD: In a randomized, double-blind study, 31 patients with stage II breast cancer and with no evidence of disease received subcutaneous injections of either placebo or oxidized mannan-MUC1, to immunize against MUC1 and prevent cancer reoccurrence/metastases. Twenty-eight patients received the full course of injections of either oxidized mannan-MUC1 or placebo. Survival and immunological assays were assessed. RESULTS: After more than 5.5 years had elapsed since the last patient began treatment (8.5 years from the start of treatment of the first patient), the recurrence rate in patients receiving the placebo was 27% (4/15; the expected rate of recurrence in stage II breast cancer); those receiving immunotherapy had no recurrences (0/16), and this finding was statistically significant (P = 0.0292). Of the patients receiving oxidized mannan-MUC1, nine out of 13 had measurable antibodies to MUC1 and four out of 10 had MUC1-specific T cell responses; none of the placebo-treated patients exhibited an immune response to MUC1. CONCLUSION: The results suggest that, in early breast cancer, MUC1 immunotherapy is beneficial, and that a larger phase III study should be undertaken
Symptomatic Abdominal Simple Cysts: Is Percutaneous Sclerotherapy with Hypertonic Saline and Bleomycin a Treatment Option?
Aim. To evaluate the feasibility of percutaneous sclerotherapy of symptomatic simple abdominal cysts, using hypertonic saline and bleomycin, as an alternative to surgery. Materials and Methods. This study involved fourteen consecutive patients (ten women, four men, mean age: 59.2 y) with nineteen symptomatic simple cysts (liver n=14, kidney n=3, and adrenal n=2) treated percutaneously using a modified method. Initially CT-guided drainage was performed; the next day the integrity of the cyst/exclusion of extravasation or communications was evaluated under fluoroscopy, followed by two injections/reabsorptions of the same quantity of hypertonic NaCl 15% solution and three-time repetition of the same procedure with the addition of bleomycin. The catheter was then removed; the patients were hospitalized for 12 hours and underwent follow-ups on 1st, 3rd, 6th, and 12th months. Cyst’s volumes and the reduction rate (%) were calculated in each evaluation. Results. No pain or complications were noted. A significant cyst’s volume reduction was documented over time (P<0.001). On the 12th month 17 cysts disappeared and two displayed a 98.7% and 68.9% reduction, respectively. Conclusion. This percutaneous approach constitutes a very promising nonsurgical alternative for patients with symptomatic simple cyst, without complications under proper precautions, leading to eliminating the majority of cysts
Two different quasiparticle scattering rates in vortex line liquid phase of layered d-wave superconductors
We carry out a quantum mechanical analysis of the behavior of nodal
quasiparticles in the vortex line liquid phase of planar d-wave
superconductors. Applying a novel path integral technique we calculate a number
of experimentally relevant observables and demonstrate that in the low-field
regime the quasiparticle scattering rates deduced from photoemission and
thermal transport data can be markedly different from that extracted from
tunneling, specific heat, superfluid stiffness or spin-lattice relaxation time.Comment: Latex, 4 pages, no figure
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