Comparison of spike production in pp and pi(+)p/K(+)p interactions at 205-360 GeV/c

Contains fulltext : 26216.pdf (publisher's version ) (Open Access

Distribution of Non-AT1, Non-AT2 Binding of 125I-Sarcosine1, Isoleucine8 Angiotensin II in Neurolysin Knockout Mouse Brains

The recent identification of a novel binding site for angiotensin (Ang) II as the peptidase neurolysin (E.C. 3.4.24.16) has implications for the renin-angiotensin system (RAS). This report describes the distribution of specific binding of 125I-Sarcosine1, Isoleucine8 Ang II (125I-SI Ang II) in neurolysin knockout mouse brains compared to wild-type mouse brains using quantitative receptor autoradiography. In the presence of p-chloromercuribenzoic acid (PCMB), which unmasks the novel binding site, widespread distribution of specific (3 µM Ang II displaceable) 125I-SI Ang II binding in 32 mouse brain regions was observed. Highest levels of binding >700 fmol/g initial wet weight were seen in hypothalamic, thalamic and septal regions, while the lowest level of binding <300 fmol/g initial wet weight was in the mediolateral medulla. 125I-SI Ang II binding was substantially higher by an average of 85% in wild-type mouse brains compared to neurolysin knockout brains, suggesting the presence of an additional non-AT1, non-AT2, non-neurolysin Ang II binding site in the mouse brain. Binding of 125I-SI Ang II to neurolysin in the presence of PCMB was highest in hypothalamic and ventral cortical brain regions, but broadly distributed across all regions surveyed. Non-AT1, non-AT2, non-neurolysin binding was also highest in the hypothalamus but had a different distribution than neurolysin. There was a significant reduction in AT2 receptor binding in the neurolysin knockout brain and a trend towards decreased AT1 receptor binding. In the neurolysin knockout brains, the size of the lateral ventricles was increased by 56% and the size of the mid forebrain (-2.72 to +1.48 relative to Bregma) was increased by 12%. These results confirm the identity of neurolysin as a novel Ang II binding site, suggesting that neurolysin may play a significant role in opposing the pathophysiological actions of the brain RAS and influencing brain morphology

Nijmegen preprint HEN-360 (July 1993)

. Meson-nucleon quasi-elastic scattering is studied with (semi) inclusive production of a central hadron cluster. The dominant mechanism of central cluster production is double pomeron exchange. The cross section is (39 \Sigma 5 \Sigma 8)¯b and (24 \Sigma 6 \Sigma 3)¯b for pion and kaon induced reactions, respectively. An estimate of the pomeron-pomeron total cross section oe PP is extracted in the interval 4m ß ! p s PP ! 2 GeV. While oe PP =0.45\Sigma0:10mb is obtained in the f 2 (1270) region, an almost constant cross section with an average of oe PP =0.16\Sigma0.02mb is observed outside the f 2 region. a Now at MPI, Munich, Germany b EC guest scientist c Bevoegdverklaard Navorser NFWO, Belgium d Partially supported by grants fromCPBP 01.06 and 01.09 1 Introduction Diffractive processes, observed both in hadron-hadron and lepton-hadron scattering, proceed predominantly via pomeron exchange. Despite extensive studies of diffractive elastic scattering and inelastic diffrac..

Angular Dependence of Particle Correlations in

. A sample of non-diffractive ß + p and K + p collisions at p s=22 GeV is used to investigate the angular dependence of the particle-particle correlation (PPC) and its asymmetry (PPCA) for soft hadronic data. The results differ strongly from the overall behavior in e + e \Gamma data, but agree with that expected for e + e \Gamma 2-jet data. For the hadronic collisions, the effect depends strongly on the charge configuration of the pairs and on the rapidity range covered. The FRITIOF Monte-Carlo model gives qualitative agreement with the trend of the overall data when Bose-Einstein correlations are included, but differs considerably in the central rapidity region. 1 EC guest scientist, now at DESY, Hamburg 2 KUN Fellow from the Jagellonian University, Krakow 3 Supported by the Polish State Committee for Scientific Research 4 Onderzoeksleider NFWO, Belgium 5 Now at UIA, Wilrijk, Belgium 6 FOM guest at the Univ. of Nijmegen 7 NWO guest at the Univ. of Nijmegen ..