Coherent control of the cooperative branching ratio for nuclear x-ray pumping

Coherent control of nuclear pumping in a three level system driven by x-ray light is investigated. In single nuclei, the pumping performance is determined by the branching ratio of the excited state populated by the x-ray pulse. Our results are based on the observation that in ensembles of nuclei, cooperative excitation and decay leads to a greatly modified nuclear dynamics, which we characterize by a time-dependent cooperative branching ratio. We discuss prospects of steering the x-ray pumping by coherently controlling the cooperative decay. First, we study an ideal case with purely superradiant decay and perfect control of the cooperative emission. A numerical analysis of x-ray pumping in nuclear forward scattering with coherent control of the cooperative decay via externally applied magnetic fields is presented. Next, we provide an extended survey of nuclei suitable for our scheme, and propose proof-of-principle implementations already possible with typical M\"ossbauer nuclear systems such as $^{57}\mathrm{Fe}$. Finally, we discuss the application of such control techniques to the population or depletion of long-lived nuclear states.Comment: 11 pages, 8 figures; updated to the published versio

Inhibition of Neurogenic Inflammatory Pathways Associated with the Reduction in Discogenic Back Pain

Study Design Retrospective cohort study. Purpose This study aimed to determine whether the initiation of anti-calcitonin gene-related peptide (CGRP inhibitor) medication therapy for migraines was also associated with improvements in back/neck pain, mobility, and function in a patient population with comorbid degenerative spinal disease and migraine. Overview of Literature CGRP upregulates pro-inflammatory cytokines such as tumor necrosis factor-α, interleukin-6, brain-derived neurotrophic factor, and nerve growth factor in spinal spondylotic disease, which results in disc degeneration and sensitization of nociceptive neurons. Although CGRP inhibitors can quell neurogenic inflammation in migraines, their off-site efficacy as a therapeutic target for discogenic back/neck pain conditions remains unknown. Methods All adult patients diagnosed with spinal spondylosis and migraine treated with CGRP inhibitors at a single academic institution between 2017 and 2020 were retrospectively identified. Patient demographic and medical data, follow-up duration, migraine severity and frequency, spinal pain, functional status, and mobility before and after the administration of CGRP inhibitors were collected. Paired univariate analysis was conducted to determine significant changes in spinal pain, headache severity, and headache frequency before and after the administration of CGRP inhibitors. The correlation between changes in the spinal pain score and functional or mobility improvement was assessed with Spearman’s rho. Results In total, 56 patients were included. The mean follow-up time after the administration of CGRP inhibitors was 123 days for spinal pain visits and 129 days for migraine visits. Back/neck pain decreased significantly (p<0.001) from 6.30 to 4.36 after starting CGRP inhibitor therapy for migraine control. As recorded in the spine follow-up notes, 25% of patients experienced a functional improvement in the activities of daily living, and 17.5% experienced mobility improvement while taking CGRP inhibitors. Change in back/neck pain moderately correlated (ρ=−0.430) with functional improvement but was not correlated with mobility improvement (ρ=−0.052). Conclusions Patients taking CGRP inhibitors for chronic migraines with comorbid degenerative spinal conditions experienced significant off-target reduction of back/neck pain

Honey, a Gift from Nature to Health and Beauty: A Review

Benefits of honey are contributed by the composition of its elements such as glucose, fructose, glucose oxidase, vitamins and phenolic compounds. For health, honey can be used to treat wounds due to the antibacterial activity conferred by the hydrogen peroxide produced by glucose oxidase in honey. Anti-inflammatory, anti-oxidant, deodorizing and tissue regeneration activities in honey also help in the wound healing process. It can also be an alternative sweetener for diabetic patients to ensure compliance to a healthy diet. Moreover, honey exerts several effects such as lowering low density lipids and increasing high density lipids, thus reducing risk of atherosclerosis. In terms of beauty, honey can be used on skin and hair. It moisturizes skin through its natural humectant properties contributed by high contents of fructose and glucose. Honey treats acne on the skin due to its antibacterial activity, anti-inflammatory action and tissue repair. The hair can benefit from honey in such a way that the hair has abundance, and becomes easier to comb. However, there have not been as many studies regarding the use of honey in skin in comparison to its use for health. Therefore, future studies on honey could research its use, action and benefits in both cosmetics and dermatology

Estimation of the spallation-residue angular momentum in p+Ta, Re reactions

Yields and cross-sections for the radioactive isotope production have been determined via gamma-activity measurements after irradiation of the Ta and Re targets by protons with energies from 100 to 660 MeV. Mass distribution of the reaction products contains two wide peaks corresponding to the spallation and fission product nuclei, respectively. High-spin Hf and Lu isomers are among the detected nuclides. The spallation-residue angular momentum I has been estimated basing on the determined isomer-to-ground state ratio sigma sub m /sigma sub g versus I. Nonzero value of spin I should increase the probability of fission. The measured fission-to-spallation ratio is indeed higher than that predicted by the Monte Carlo code simulation without angular momentum in accoun

Role of environmental, climatic risk factors and livestock animals on the occurrence of cutaneous leishmaniasis in newly emerging focus in Iran

Introduction: Occurrence of leishmaniasis is affected by various biological and environmental factors. Kohgiluye and Boyerahmad (K–B) province is an emerging focus of cutaneous leishmaniasis (CL) in Southwest Iran. Subjects and methods: To elucidate some angles of occurrence of CL in this province, climatic and environmental factors and close proximity to livestock were studied by univariate and two multivariate logistic regression models. The dwelling addresses of 275 CL patients were obtained from Health Centers records for a 5 years period. The effect of mean annual temperature, minimum mean annual temperature, maximum mean annual temperature, mean annual rainfall, slope, elevation, land covers and close proximity to cattle and sheep/goat sheds on the occurrence of CL were analysed using geographical information systems (GIS) approach. Results: CL occurred in all counties with the most cases in Northwest, West and South semi-arid and warm regions. Land cover, slope, elevation and close proximity to cattle sheds, were the most effective factors. Urban, dry farm and thin rangeland were found as the most important land covers. Slope and elevation decreased the probability of disease. Close proximity to cattle sheds notably increased the chance of CL. The importance of other factors such as rainfall, temperature and close proximity to sheep/goat sheds only were shown when their effects were evaluated independently from other factors. So regions with urban, dry farm and thin rangeland covers with lower slope and altitude where in close proximity of cattle sheds seems to be potentially most high risk areas. Conclusion: Distribution of CL cases is influenced by combination of environmental, ecological factors and close proximity to livestock sheds but control programs should be focused on cities and villages in the above-mentioned most high risk regions. Keywords: Cutaneous leishmaniasis, GIS, Land cover, Slope, Elevatio