975 research outputs found
The effect of 12 weeks regular physical activity and vitamin E in the treatment of non-alcoholic steatohepatitis: A pilot study
Background: Despite the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH), there was no treatment has been proven to be effective in these common diseases. Although many studies have shown that lifestyle modifications such as increasing physical activities and exercise could be effective in the treatment of these common diseases, the optimal strategy was still not determined. According to the beneficial effects of antioxidant agents in the treatment of NASH, vitamin E has been used for this purpose by some clinicians. We designed this study for assessing beneficial effects of regular physical activity on the biochemical and imaging responses in patients with NASH and comparing this with vitamin E as an accepted treatment for NASH. Materials and Methods: This study was Randomized and single-blind clinical trials were carried out in Gonbad-e Kavus through which a total of 30 consecutive patients with the ultra sonographic diagnosis of non-alcoholic steatohepatitis (NASH)were enrolled and randomized to one of the three groups: Vitamin E 800 mg/day, regular physical activity, or both. Results: In all treatment groups improvement in liver transaminases level, serum lipids and ultrasonographic grading of fatty liver occurred after three months of treatment. When these decrement was compared between the treatment groups, there was no statistically significant difference in the value of improvement between the three groups (ANOVA: p>0.5). I.e. all three interventions improved the biochemical and ultrasonographic finding of fatty liver in the same way. Both groups with regular exercise had significant mean weight loss in comparison with the vitamin E group (a mean decrease of 3.0 kg in exercise group, 5.8 kg in subjects on regular exercise plus vitamin E and 0.2 kg in vitamin E group, ANOVA: p=0.04). Conclusion: There were no significant differences between exercise and vitamin E alone or in combination regarding the reduction in the level of liver enzymes and sonographic evidences of fatty liver although both resulted in significant improvements in biochemical endpoints. This implies that physical activity could be considered as effective as vitamin E in the improvement of biochemical and ultrasonographic presentations of NASH and the addition of Vitamin E does not offer any benefits. According to the findings of this pilot study a full-powered study with a control group should be designed. © 2015, Iranian Association of Gastroenterology and Hepatology. All rights reserved
The effect of 12 weeks regular physical activity and vitamin E in the treatment of non-alcoholic steatohepatitis: A pilot study
Background: Despite the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH), there was no treatment has been proven to be effective in these common diseases. Although many studies have shown that lifestyle modifications such as increasing physical activities and exercise could be effective in the treatment of these common diseases, the optimal strategy was still not determined. According to the beneficial effects of antioxidant agents in the treatment of NASH, vitamin E has been used for this purpose by some clinicians. We designed this study for assessing beneficial effects of regular physical activity on the biochemical and imaging responses in patients with NASH and comparing this with vitamin E as an accepted treatment for NASH. Materials and Methods: This study was Randomized and single-blind clinical trials were carried out in Gonbad-e Kavus through which a total of 30 consecutive patients with the ultra sonographic diagnosis of non-alcoholic steatohepatitis (NASH)were enrolled and randomized to one of the three groups: Vitamin E 800 mg/day, regular physical activity, or both. Results: In all treatment groups improvement in liver transaminases level, serum lipids and ultrasonographic grading of fatty liver occurred after three months of treatment. When these decrement was compared between the treatment groups, there was no statistically significant difference in the value of improvement between the three groups (ANOVA: p>0.5). I.e. all three interventions improved the biochemical and ultrasonographic finding of fatty liver in the same way. Both groups with regular exercise had significant mean weight loss in comparison with the vitamin E group (a mean decrease of 3.0 kg in exercise group, 5.8 kg in subjects on regular exercise plus vitamin E and 0.2 kg in vitamin E group, ANOVA: p=0.04). Conclusion: There were no significant differences between exercise and vitamin E alone or in combination regarding the reduction in the level of liver enzymes and sonographic evidences of fatty liver although both resulted in significant improvements in biochemical endpoints. This implies that physical activity could be considered as effective as vitamin E in the improvement of biochemical and ultrasonographic presentations of NASH and the addition of Vitamin E does not offer any benefits. According to the findings of this pilot study a full-powered study with a control group should be designed. © 2015, Iranian Association of Gastroenterology and Hepatology. All rights reserved
A Facile and Practical p-Toluenesulfonic Acid Catalyzed Route to Dicoumarols Containing an Aroyl group
New and known dicoumarols may be efficiently synthesized employing p-toluenesulfonic acid (p-TSA) as a solid acid catalyst from the reaction of 4-hydroxycoumarin with aryl glyoxal in water. This method offers direct access to structurally diverse coumarin derivatives in moderate to good yields (up to 65%). A total of five new compounds were synthesized.KEYWORDS Dicoumarol, p-toluenesulfonic acid, aryl glyoxal, 4-hydroxycoumarin.PDF and Supp files attache
Growth factor in f(T) gravity
We derive the evolution equation of growth factor for the matter over-dense
perturbation in gravity. For instance, we investigate its behavior in
power law model at small redshift and compare it to the prediction of
CDM and dark energy with the same equation of state in the framework
of Einstein general relativity. We find that the perturbation in gravity
grows slower than that in Einstein general relativity if \p f/\p T>0 due to
the effectively weakened gravity.Comment: 15 pages,1 figure; v2,typos corrected; v3, discussions added,
accepted by JCA
Assessing the role of Ca2+ in skeletal muscle fatigue using a multi-scale continuum model
The Calcium ion Ca2+ plays a critical role as an initiator and preserving agent of the cross-bridge cycle in the force generation of skeletal muscle. A new multi-scale chemo-mechanical model is presented in order to analyze the role of Ca2+ in muscle fatigue and to predict fatigue behavior. To this end, a cross-bridge kinematic model was incorporated in a continuum based mechanical model, considering a thermodynamic compatible framework. The contractile velocity and the generated active force were directly related to the force-bearing states that were considered for the cross-bridge cycle. In order to determine the values of the model parameters, the output results of an isometric simulation were initially fitted with experimental data obtained for rabbit Extensor Digitorum Longus muscle. Furthermore, a simulated force-velocity curve under concentric contractions was compared with reported experimental results. Finally, by varying the Ca2+ concentration level and its kinetics in the tissue, the model was able to predict the evolution of the active force of an experimental fatigue protocol. The good agreement observed between the simulated results and the experimental outcomes proves the ability of the model to reproduce the fatigue behavior and its applicability for more detailed multidisciplinary investigations related to chemical conditions in muscle performance
Interacting entropy-corrected new agegraphic dark energy in Brans-Dicke cosmology
Motivated by a recent work of one of us [1], we extend it by using quantum
(or entropy) corrected new agegraphic dark energy in the Brans-Dicke cosmology.
The correction terms are motivated from the loop quantum gravity which is one
of the competitive theories of quantum gravity. Taking the non-flat background
spacetime along with the conformal age of the universe as the length scale, we
derive the dynamical equation of state of dark energy and the deceleration
parameter. An important consequence of this study is the phantom divide
scenario with entropy-corrected new agegraphic dark energy. Moreover, we assume
a system of dark matter, radiation and dark energy, while the later interacts
only with dark matter. We obtain some essential expressions related with dark
energy dynamics. The cosmic coincidence problem is also resolved in our model.Comment: 16 pages, no figure, accepted for publication in Gen. Relativ. Gra
Prevalence of and Some Factors Relating with Unwanted Pregnancy, in Ahwaz City, Iran, 2010
We aimed to find the
prevalence and some factors relating with unwanted
pregnancy. Methods. It was a
cross-sectional study on 400 randomly pregnant
women, who were referring to different health
centers in Ahwaz city during 2010. Data was
conducted based on questionnaire, and all the
analysis was performed using SPSS (version 17)
statistical analysis software.
Results. The prevalence of
unwanted pregnancy was 26%. The percentage of
unwanted pregnancy in ages more than 35 years was
approximately three times more than the intended
pregnancy. There were significant relationship
between unwanted pregnancy and some variables such
as age, number of pregnancy, number of childbirth,
education status, economic status, husband's
occupation, and the relationship with the spouse
and contraceptive methods (P < 0.0001). Conclusion. The
prevalence of unwanted pregnancy was high. To
prevent unwanted pregnancy using consultation
services before planning to be pregnancy, it is
necessary to identify the factors relating
with unwanted pregnancy
Interacting viscous ghost tachyon, K-essence and dilaton scalar field models of dark energy
We study the correspondence between the interacting viscous ghost dark energy
model with the tachyon, K-essence and dilaton scalar field models in the
framework of Einstein gravity. We consider a spatially non-flat FRW universe
filled with interacting viscous ghost dark energy and dark matter. We
reconstruct both the dynamics and potential of these scalar field models
according to the evolutionary behavior of the interacting viscous ghost dark
energy model, which can describe the accelerated expansion of the universe. Our
numerical results show that the interaction and viscosity have opposite effects
on the evolutionary properties of the ghost scalar filed models.Comment: 16 pages, 17 figure
Reconstructing interacting new agegraphic polytropic gas model in non-flat FRW universe
We study the correspondence between the interacting new agegraphic dark
energy and the polytropic gas model of dark energy in the non-flat FRW
universe. This correspondence allows to reconstruct the potential and the
dynamics for the scalar field of the polytropic model, which describe
accelerated expansion of the universe.Comment: 9 page
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