Effect of lawsonia inermis treatment on mice with sarcoma

Lawsonia inermis commonly is used as cosmetic material. However many studies had shown that L. inermis had antitumoural, antimicrobial and anti-tuberculostatic effects. The aim of this study was to investigate whether L. inermis can destroy cancer cells by induction of apoptosis due to decreasing of intracellular H+ ion level or increasing intracellular free radicals and H2O2 levels in cancer cells as a result of oxidative effect or not. We used 70 female Swiss albino mice and divided them into four groups. Group 1 was given only tap water. Group 2 was given only L. inermis. Group 3 was given Ehrlich ascites tumour (EAT) cells + tap water and Group 4 was given EAT + L. inermis. At the result of this study the thickness of subcutaneous lipid tissue, diameters of gluteal mass, the pH levels of gluteal mass, the GSH levels at the liver tissue samples and the MDA levels of the liver tissue samples of these groups were measured. This study showed that, L. inermis can be used as a supplementary agent for cancer treatment. © 2008 Academic Journals

A snapshot of geriatric infections in Turkey: ratio of geriatric inpatients in hospitals and evaluation of their infectious diseases: A multicenter point prevalence study

Introduction: The human population is aging at an astonishing rate. The aim of this study is to capture a situation snapshot revealing the proportion of individuals aged 65 years and over among inpatients in healthcare institutions in Turkey and the prevalence and type of infections in this patient group in order to draw a road map. Materials and Methods: Hospitalized patients over 65 years at any of the 62 hospitals in 29 cities across Turkey on February 9, 2017 were included in the study. Web-based SurveyMonkey was used for data recording and evaluation system. Results: Of 17,351 patients 5871 (33.8%) were ≥65 years old. The mean age was 75.1 ± 7.2 years; 3075 (52.4%) patients were male. Infection was reason for admission for 1556 (26.5%) patients. Pneumonia was the most common infection. The median length of hospital stay was 5 days (IQR: 2–11 days). The Antibiotic therapy was initiated for 2917 (49.7%) patients at the time of admission, and 23% of the antibiotics prescribed were inappropriate. Healthcare-associated infections developed in 1059 (18%) patients. Urinary catheters were placed in 2388 (40.7%) patients with 7.5% invalid indication. Conclusion: This study used real data to reveal the proportion of elderly patients in hospital admissions. The interventions done, infections developed during hospitalization, length of hospital stay, and excessive drug load emphasize the significant impact on health costs and illustrate the importance of preventive medicine in this group of patients. © 2020 The Author