On unbounded bodies with finite mass: asymptotic behaviour

There is introduced a class of barotropic equations of state (EOS) which become polytropic of index $n = 5$ at low pressure. One then studies asymptotically flat solutions of the static Einstein equations coupled to perfect fluids having such an EOS. It is shown that such solutions, in the same manner as the vacuum ones, are conformally smooth or analytic at infinity, when the EOS is smooth or analytic, respectively.Comment: 6 page

Thin Domain Walls in Lyra Geometry

This paper studies thin domain walls within the frame work of Lyra Geometry. We have considered two models. First one is the thin domain wall with negligible pressures perpendicular and transverse direction to the wall and secondly, we take a particular type of thin domain wall where the pressure in the perpendicular direction is negligible but transverse pressures are existed. It is shown that the thin domain walls have no particle horizon and the gravitational force due to them is attractive.Comment: 8 pages, typos are corrected, published Astrophysics and Space Sciences 305, 337 (2006

Functional dynamics of a single tryptophan residue in a BLUF protein revealed by fluorescence spectroscopy

Blue Light Using Flavin (BLUF) domains are increasingly being adopted for use in optogenetic constructs. Despite this, much remains to be resolved on the mechanism of their activation. The advent of unnatural amino acid mutagenesis opens up a new toolbox for the study of protein structural dynamics. The tryptophan analogue, 7-aza-Trp (7AW) was incorporated in the BLUF domain of the Activation of Photopigment and pucA (AppA) photoreceptor in order to investigate the functional dynamics of the crucial W104 residue during photoactivation of the protein. The 7-aza modification to Trp makes selective excitation possible using 310 nm excitation and 380 nm emission, separating the signals of interest from other Trp and Tyr residues. We used Förster energy transfer (FRET) between 7AW and the flavin to estimate the distance between Trp and flavin in both the light- and dark-adapted states in solution. Nanosecond fluorescence anisotropy decay and picosecond fluorescence lifetime measurements for the flavin revealed a rather dynamic picture for the tryptophan residue. In the dark-adapted state, the major population of W104 is pointing away from the flavin and can move freely, in contrast to previous results reported in the literature. Upon blue-light excitation, the dominant tryptophan population is reorganized, moves closer to the flavin occupying a rigidly bound state participating in the hydrogen-bond network around the flavin molecule

Molecular mapping of dry root rot resistance genes in chickpea (Cicer arietinum L.)

Dry root rot (DRR) caused by Rhizoctonia bataticola [(Taub.) Butler] is an emerging disease of chickpea (Cicer arietinum L.) and a serious constraint to chickpea production in warm and arid regions. To identify the genomic regions conferring resistance to DRR, a total of 182 F9 derived Recombinant Inbred Lines (RILs) were developed from the cross between a susceptible line BG 212 and moderately resistant breeding line ICCV 08305. The parental lines and RILs were screened against Rb 6 isolate of R. bataticola using paper towel method under controlled environment at ICRISAT during 2016 and 2017. The RILs were genotyped with cost-effective SNP genotyping platform, Affymetrix Axiom CicerSNP array. As a result, a high-density genetic map with 13,110 SNP markers spanning 1224.11 cM with an average inter marker distance of 0.09 cM was developed. A single minor QTL (‘qDRR-8’) explaining 6.70% PVE with LOD scores 3.34 was identified on CaLG08 for DRR resistance which could be further explored for mining candidate genes and the linked SNP markers could be further validated for application in marker-assisted selection of DRR resistance in chickpea breeding programs

Itraconazole associated quadriparesis and edema: a case report

<p>Abstract</p> <p>Introduction</p> <p>Itraconazole is an anti-fungal agent widely used to treat various forms of mycosis. It is particularly useful in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization. Side effects are uncommon and usually mild. Mild neuropathy is noted to occur very rarely. We present an unusual and, to the best of our knowledge, as yet unreported case of severe neuropathy and peripheral edema due to itraconazole in the absence of a concomitant risk factor.</p> <p>Case presentation</p> <p>A 72-year-old Caucasian man was started on itraconazole following diagnosis of severe asthma with fungal sensitization. One month later he presented with severe bilateral ankle edema with an elevated serum itraconazole level. The itraconazole dose was reduced but his ankle edema persisted and he developed weakness of all four limbs. Itraconazole was completely stopped leading to improvement in his leg edema but he became bed bound due to weakness. He gradually improved with supportive care and neurorehabilitation. On review at six months, our patient was able to mobilize with the aid of two elbow crutches and power had returned to 5/5 in distal extremities and 4+/5 in proximal extremities. The diagnosis was established based on the classical presentation of drug-induced neuropathy and negative investigatory findings for any alternative diagnoses.</p> <p>Conclusion</p> <p>We report the case of a patient presenting with an unusual complication of severe neuropathy and peripheral edema due to itraconazole. Clinicians should be alert to this association when encountered with neuropathy and/or edema in an itraconazole therapy recipient.</p