ALFA: A framework for building distributed applications

The ALFA framework is a joint development between ALICE Online-Offline and FairRoot teams. ALFA has a distributed architecture, i.e. a collection of highly maintainable, testable, loosely coupled, independently deployable processes. ALFA allows the developer to focus on building singlefunction modules with well-defined interfaces and operations. The communication between the independent processes is handled by FairMQ transport layer. FairMQ offers multiple implementations of its abstract data transport interface, it integrates some popular data transport technologies like ZeroMQ and nanomsg. Furthermore it also provides shared memory and RDMA transport (based on libfabric) for high throughput, low latency applications. Moreover, FairMQ allows the single process to use multiple and different transports at the same time. FairMQ based processes can be controlled and orchestrated via different systems by implementing the corresponding plugin. However, ALFA delivers also the Dynamic Deployment System (DDS) as an independent set of utilities and interfaces, providing a dynamic distribution of different user processes on any Resource Management System (RMS) or a laptop. ALFA is already being tested and used by different experiments in different stages of data processing as it offers an easy integration of heterogeneous hardware and software

ALFA: A framework for building distributed applications

The ALFA framework is a joint development between ALICE Online-Offline and FairRoot teams. ALFA has a distributed architecture, i.e. a collection of highly maintainable, testable, loosely coupled, independently deployable processes. ALFA allows the developer to focus on building singlefunction modules with well-defined interfaces and operations. The communication between the independent processes is handled by FairMQ transport layer. FairMQ offers multiple implementations of its abstract data transport interface, it integrates some popular data transport technologies like ZeroMQ and nanomsg. Furthermore it also provides shared memory and RDMA transport (based on libfabric) for high throughput, low latency applications. Moreover, FairMQ allows the single process to use multiple and different transports at the same time. FairMQ based processes can be controlled and orchestrated via different systems by implementing the corresponding plugin. However, ALFA delivers also the Dynamic Deployment System (DDS) as an independent set of utilities and interfaces, providing a dynamic distribution of different user processes on any Resource Management System (RMS) or a laptop. ALFA is already being tested and used by different experiments in different stages of data processing as it offers an easy integration of heterogeneous hardware and software

A Signature of 14 Long Non-Coding RNAs (lncRNAs) as a Step towards Precision Diagnosis for NSCLC

LncRNAs have arisen as new players in the world of non-coding RNA. Disrupted expression of these molecules can be tightly linked to the onset, promotion and progression of cancer. The present study estimated the usefulness of 14 lncRNAs (HAGLR, ADAMTS9-AS2, LINC00261, MCM3AP-AS1, TP53TG1, C14orf132, LINC00968, LINC00312, TP73-AS1, LOC344887, LINC00673, SOX2-OT, AFAP1-AS1, LOC730101) for early detection of non-small-cell lung cancer (NSCLC). The total RNA was isolated from paired fresh-frozen cancerous and noncancerous lung tissue from 92 NSCLC patients diagnosed with either adenocarcinoma (LUAD) or lung squamous cell carcinoma (LUSC). The expression level of lncRNAs was evaluated by a quantitative real-time PCR (qPCR). Based on Ct and delta Ct values, logistic regression and gradient boosting decision tree classifiers were built. The latter is a novel, advanced machine learning algorithm with great potential in medical science. The established predictive models showed that a set of 14 lncRNAs accurately discriminates cancerous from noncancerous lung tissues (AUC value of 0.98 ± 0.01) and NSCLC subtypes (AUC value of 0.84 ± 0.09), although the expression of a few molecules was statistically insignificant (SOX2-OT, AFAP1-AS1 and LOC730101 for tumor vs. normal tissue; and TP53TG1, C14orf132, LINC00968 and LOC730101 for LUAD vs. LUSC). However for subtypes discrimination, the simplified logistic regression model based on the four variables (delta Ct AFAP1-AS1, Ct SOX2-OT, Ct LINC00261, and delta Ct LINC00673) had even stronger diagnostic potential than the original one (AUC value of 0.88 ± 0.07). Our results demonstrate that the 14 lncRNA signature can be an auxiliary tool to endorse and complement the histological diagnosis of non-small-cell lung cancer

FairRootGroup/FairMQ: v1.3.8

[bug fixes] 291d00c Fix regression with ignored rateLogging channel argument 0cb8f61 Let getMessage deal with SSO [enhancement] 4dc37ef Allow implicit conversion factory->resourc