Elaine\u27s Installation

Poem written for the installation of Elaine P. Maimon as President of Governors State University

Subcultural Influences on Self-attitudes: The Expression of Low Self-esteem in Race/ethnicity-, Age-, Gender-, Social class-, and Generation-differentiated Subgroups

Self-esteem is conceptualized in terms of self-feelings that are evoked by self-evaluation of self-concept and that motivate self-enhancing or self-protective responses. Since (sub)cultural conventions and the self-esteem motive frequently invalidate self-report measures, it is argued that self-esteem should be measured as the confluence of self-evaluative statements and measures of subjective distress. In support of this, findings are presented from a longitudinal multigeneration study that demonstrate variation in the association between self-evaluative statements and reports of emotional distress between groups differentiated according to race/ethnicity, age, gender, social class, and generation. The results clearly indicate that prevalent self-report measures, whether considering total scores or component items, have differential emotional significance depending on groupings.

Co‐located Nonprofit Centers

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108607/1/nml21110.pd

Altered sterol metabolism in budding yeast affects mitochondrial iron–sulfur (Fe-S) cluster synthesis

Ergosterol synthesis is essential for cellular growth and viability of the budding yeast Saccharomyces cerevisiae, and intracellular sterol distribution and homeostasis are therefore highly regulated in this species. Erg25 is an iron-containing C4-methyl sterol oxidase that contributes to the conversion of 4,4-dimethylzymosterol to zymosterol, a precursor of ergosterol. The ERG29 gene encodes an endoplasmic reticulum (ER)-associated protein, and here we identified a role for Erg29 in the methyl sterol oxidase step of ergosterol synthesis. ERG29 deletion resulted in lethality in respiring cells, but respiration-incompetent (Rho- or Rho0) cells survived, suggesting that Erg29 loss leads to accumulation of oxidized sterol metabolites that affect cell viability. Down-regulation of ERG29 expression in Δerg29 cells indeed led to accumulation of methyl sterol metabolites, resulting in increased mitochondrial oxidants and a decreased ability of mitochondria to synthesize iron-sulfur (Fe-S) clusters due to reduced levels of Yfh1, the mammalian frataxin homolog, which is involved in mitochondrial iron metabolism. Using a high-copy genomic library, we identified suppressor genes that permitted growth of Δerg29 cells on respiratory substrates, and these included genes encoding the mitochondrial proteins Yfh1, Mmt1, Mmt2, and Pet20, which reversed all phenotypes associated with loss of ERG29 Of note, loss of Erg25 also resulted in accumulation of methyl sterol metabolites and also increased mitochondrial oxidants and degradation of Yfh1. We propose that accumulation of toxic intermediates of the methyl sterol oxidase reaction increases mitochondrial oxidants, which affect Yfh1 protein stability. These results indicate an interaction between sterols generated by ER proteins and mitochondrial iron metabolism

Professional training during retrenchment: Government and university collaboration with public psychiatric hospitals

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44089/1/10488_2004_Article_BF00707263.pd