Early changes in biochemical markers of bone formation during teriparatide therapy correlate with improvements in vertebral strength in men with glucocorticoid-induced osteoporosis

Summary: Changes of the bone formation marker PINP correlated positively with improvements in vertebral strength in men with glucocorticoid-induced osteoporosis (GIO) who received 18-month treatment with teriparatide, but not with risedronate. These results support the use of PINP as a surrogate marker of bone strength in GIO patients treated with teriparatide. Introduction: To investigate the correlations between biochemical markers of bone turnover and vertebral strength estimated by finite element analysis (FEA) in men with GIO. Methods: A total of 92 men with GIO were included in an 18-month, randomized, open-label trial of teriparatide (20 μg/day, n = 45) and risedronate (35 mg/week, n = 47). High-resolution quantitative computed tomography images of the 12th thoracic vertebra obtained at baseline, 6 and 18 months were converted into digital nonlinear FE models and subjected to anterior bending, axial compression and torsion. Stiffness and strength were computed for each model and loading mode. Serum biochemical markers of bone formation (amino-terminal-propeptide of type I collagen [PINP]) and bone resorption (type I collagen cross-linked C-telopeptide degradation fragments [CTx]) were measured at baseline, 3 months, 6 months and 18 months. A mixed-model of repeated measures analysed changes from baseline and between-group differences. Spearman correlations assessed the relationship between changes from baseline of bone markers with FEA variables. Results: PINP and CTx levels increased in the teriparatide group and decreased in the risedronate group. FEA-derived parameters increased in both groups, but were significantly higher at 18 months in the teriparatide group. Significant positive correlations were found between changes from baseline of PINP at 3, 6 and 18 months with changes in FE strength in the teriparatide-treated group, but not in the risedronate group. Conclusions: Positive correlations between changes in a biochemical marker of bone formation and improvement of biomechanical properties support the use of PINP as a surrogate marker of bone strength in teriparatide-treated GIO patients

Thoracic cord compression caused by disk herniation in Scheuermann’s disease: A case report and review of the literature

We present the case of a 14-year-old male with Scheuermann’s disease and significant neurological deficit due to thoracic disk herniation at the apex of kyphosis. He was treated with an anterior decompression, anterior and posterior fusion in the same setting using plate, cage and a segmental instrumentation system. The patient had an excellent outcome with complete neurological recovery

Children and adolescents with idiopathic scoliosis: Emotional reactions, coping mechanisms, and self-esteem

The main aim of the present study was to investigate the relationship among emotional responses of children and adolescents with idiopathic scoliosis towards their physical state, the coping mechanisms they used, and their self-esteem and the treatment condition of their disorder, i.e., the use of a brace or not. 82 children and adolescents ages 7 to 17 years who were attending an outpatient scoliosis clinic were administered two questionnaires; one evaluated emotional and behavioral factors linked to coping with stressful situations, and the second assessed self-esteem. Analysis showed that, after adjusting for emotion-focused coping, general self-esteem, and age, the effect of the use of brace as a treatment technique on the participants' emotional reactions was not significant. © Psychological Reports 2006

Correction to: Conducting an observational study during an economic crisis: analysis of the treatment and follow-up phase of Greek patients participating in the ExFOS study (Hormones, (2018), 17, 4, (531-540), 10.1007/s42000-018-0077-6)

Unfortunately in the original publication, the affiliation of the author N. Papaioannou was incorrectly provided. The correct affiliation for N. Papaioannou should read as follows: 4 Laboratory for the Research of Musculoskeletal System, School of Medicine, National and Kapodistrian University of Athens, Greece. © 2019, Hellenic Endocrine Society