Local progression and pseudo progression after single fraction or fractionated stereotactic radiotherapy for large brain metastases A single centre study

Clinical Oncolog

Neurocognitive functioning and health-related quality of life in patients treated with stereotactic radiotherapy for brain metastases: a prospective study

Neurolog

Residual breast tissue after mastectomy and reconstruction:A substudy of the Spatial location of breast cancer local rECurRence aftEr masTectomy (SECRET) project

The current project is part of the Spatial location of breast cancer local rECurRence aftEr masTectomy (SECRET) study (NCT06130111). Herein we compared the chest wall thickness after non-skin sparing mastectomy (non-SSM) with the chest wall thickness after SSM, as a surrogate for residual breast tissue after mastectomy. Methods: The study was approved by the ethics committee of relevant institutions. Data of patients with a local recurrence (LR) after non-SSM was collected from the Netherlands Cancer Registry (NCR); data of patients undergoing SSM were collected from Sheba Medical Center. Student's t-test was used to evaluate the difference between the cohorts. Chest wall thickness was measured on postoperative images. Results: Out of 4949 patients who underwent mastectomy from the NCR cohort, a total of 173 (3.5 %) had a LR at 5 years, of these a total of 153 patients included in the non-SSM cohort. The median age was 59 years (age 33–92), LR occurred at a median of 23.6 months (2.5–60 months). The SSM cohort included 84 patients, with a median age of 38.4 years (28–63.5), overall, 5 LRs occurred at a median of 15 months (5–46 months). The SSM cohort had significantly thicker chest walls compared to non-SSM (p &lt; 0.001). Most LRs in both groups occurred in the subcutis. Conclusion: The chest wall thickness differed according to mastectomy procedures. Most of the LR occurred at the subcutis. The role of residual breast tissue and residual cancer in relation to type of mastectomy should be further investigated.</p