Ethosuximide-loaded bismuth ferrite nanoparticles as a potential drug delivery system for the treatment of epilepsy disease

Encapsulating antiepileptic drugs (AEDs), including ethosuximide (Etho), into nanoparticles shows promise in treating epilepsy. Nanomedicine may be the most significant contributor to addressing this issue. It presents several advantages compared to traditional drug delivery methods and is currently a prominent area of focus in cancer research. Incorporating Etho into bismuth ferrite (BFO) nanoparticles within diverse controlled drug delivery systems is explored to enhance drug efficacy. This approach is primarily desired to aid in targeted drug delivery to the brain’s deepest regions while limiting transplacental permeability, reducing fetal exposure, and mitigating associated adverse effects. In this investigation, we explored Etho, an antiepileptic drug commonly employed for treating absence seizures, as the active ingredient in BFO nanoparticles at varying concentrations (10 and 15 mg). Characterization of the drug-containing BFO nanoparticles involved scanning electron microscopy (SEM) and elemental analysis. The thermal properties of the drug-containing BFO nanoparticles were evaluated via differential scanning calorimetry (DSC) analysis. Cytotoxicity evaluations using the MTT assay were conducted on all nanoparticles, and human neuroblastoma cell line cultures (SH-SY5Y) were treated with each particle over multiple time intervals. Cell viability remained at 135% after 7 days when exposed to 15 mg of Etho in BFO nanoparticles. Additionally, in vitro drug release kinetics for Etho revealed sustained release lasting up to 5 hours with a drug concentration of 15 mg

Üstün Zekalı ve Normal Gelişim Gösteren Çocukların, Mükemmeliyetçilik ve Öz-Saygı Düzeylerinin İncelenmesi

Araştırma, üstün zekalı ve normal gelişim gösteren çocukların, mükemmeliyetçilik ve öz-saygı düzeylerinin incelenmesini amaçlamaktadır. Çalışma İstanbul Üniversitesi Hasan Ali Yücel Eğitim Fakültesi, Özel Eğitim Bölümü tarafından “Üstün Zekalı Çocukların Eğitimi Projesinin” yürütüldüğü bir devlet okulunda yürütülmüştür. Örnekleme ilköğretim 2. ve 3. sınıf öğrencilerinden 53 üstün zekalı ve 31 normal gelişim gösteren toplam 84 öğrenci dahil edilmiştir. Veriler ‘Wisc-R Zeka Testi’, “OlumluOlumsuz Mükemmeliyetçilik Ölçeği” ve “Kültürden Arındırılmış Çocuklar İçin Öz-saygı Envanteri” kullanılarak toplanmıştır. Sonuçlar öz-saygının, cinsiyete ve zekaya bağlı olarak değişirken mükemmeliyetçiliğin zekaya bağlı olarak değişmediğini buna karşın kızların olumlu mükemmeliyetçilik puanlarının erkeklerden yüksek olduğunu göstermiştir. Bulgular, sosyo-duygusal eğitim programının mükemmeliyetçilik ve öz-saygı düzeylerine olan etkisinin önemini ortaya koymuştur

The use of non-conventional CPTe data in determination of 3-D electrical resistivity distribution

The spatial distribution of the electrical resistivity data provides useful information for investigating and modeling the fluid transport processes. 3D electrical resistivity distribution provides information about water flow and changes in electrical resistivity of the pore fluid.Therefore, to assist in understanding and modeling of the fluid transport process, 3D spatial distribution of the electrical resistivity data with the corresponded 3D geological section were mapped and interpreted in the test site located in western Germany. A process of deriving electrical resistivity values from the mechanical and radioactive parameters of cone penetration tests (CPT) and geological information of boreholes was presented. A reliable method which gives accurate resistivity values in cases of near surface sediments was introduced. Then a field test was executed where the calculated resistivity values were compared with the measured CPTe resistivity data. The CPTe (cone penetration test with electrical extension) data were also used in correlating to the ERT (electrical resistivity tomography) data. Consequently, obtained dense CPT surveys give us the possibility to determine a high resolution resistivity distribution of the investigated area. (C) 2010 Elsevier B.V. All rights reserved