31 research outputs found
Maternal exposure to polychlorinated biphenyls and the secondary sex ratio: an occupational cohort study
Though commercial production of polychlorinated biphenyls was banned in the United States in 1977, exposure continues due to their environmental persistence. Several studies have examined the association between environmental polychlorinated biphenyl exposure and modulations of the secondary sex ratio, with conflicting results.
Our objective was to evaluate the association between maternal preconceptional occupational polychlorinated biphenyl exposure and the secondary sex ratio.
We examined primipara singleton births of 2595 women, who worked in three capacitor plants at least one year during the period polychlorinated biphenyls were used. Cumulative estimated maternal occupational polychlorinated biphenyl exposure at the time of the infant's conception was calculated from plant-specific job-exposure matrices. A logistic regression analysis was used to evaluate the association between maternal polychlorinated biphenyl exposure and male sex at birth (yes/no).
Maternal body mass index at age 20, smoking status, and race did not vary between those occupationally exposed and those unexposed before the child's conception. Polychlorinated biphenyl-exposed mothers were, however, more likely to have used oral contraceptives and to have been older at the birth of their first child than non-occupationally exposed women. Among 1506 infants liveborn to polychlorinated biphenyl-exposed primiparous women, 49.8% were male; compared to 49.9% among those not exposed (n = 1089). Multivariate analyses controlling for mother's age and year of birth found no significant association between the odds of a male birth and mother's cumulative estimated polychlorinated biphenyl exposure to time of conception.
Based on these data, we find no evidence of altered sex ratio among children born to primiparous polychlorinated biphenyl-exposed female workers
Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice
Distribution of the Receptor for Advanced Glycation End Products Gene Polymorphisms in Patients With Chronic Periodontitis: A Preliminary Study
Association of hypertensive disorders of pregnancy risk and factor V Leiden mutation: A meta‐analysis
Association of the Receptor for Advanced Glycation End Products Gene Polymorphisms with Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis
Pilot application of multi-locus and time-to-event analysis to ascertain genetic risk factors for diabetic nephropathy and related adverse outcomes of diabetes mellitus
Exploring the therapeutic effects of micro-pulse stimulation
Electrotherapy is not so commonly used in veterinary practice as in human. Microstimulator is a new electrotherapeutic device designed especially for the horses’ patients. Its unusual configuration of pulse parameters makes this method appropriate for the swelling treatment and tissue regeneration after the minor injuries. Nine horses with swelling of the limb caused by minor injury such as tendinitis, sprains etc. were included in the study. Micro-pulse stimulation was applied once a day until the total regress of problems. The course of the experiment was documented in photographs and video recordings that were significant for evaluation of the effectiveness of micro-pulse stimulation in this application. Based on the results, it seems the micro-pulse stimulation really has positive effect on swelling reduction, and so the overall tissue regeneration, consisting probably in analgesic and anti-inflammatory effects. © Springer International Publishing AG 2018.Brno University of Technology; European Regional Development Fund under the project CEBIA-Tech Instrumentation [CZ.1.05/2.1.00/19.0376