[Review of] Craig Storti. Incident at Bitter Creek: The Story of the Rock Springs Chinese Massacre

In September 1885 a petty dispute among Euro-American and Chinese Union Pacific miners in Wyoming exploded into a homicidal spree which left twenty-five confirmed dead Chinese miners, and another twenty-six missing and presumed dead. In the weeks and months which followed, other Chinese miners and laborers were robbed, killed, or hounded out of the United States. Some of the parties responsible for these atrocities were arrested and brought to trial, but juries found no one guilty of these genocidal crimes. Many local, state, territorial, military, and federal government officials made good-faith efforts to protect the Chinese, but their efforts primarily hastened the exodus of the Chinese contract workers from American shores; for protection usually meant little more than safe passage away from the danger areas, and most of the western US was a dangerous area for Chinese nationals after Rock Springs. Craig Storti\u27s brief account of these events revives long dormant, shameful memories of an era in American history when racial and ethnic prejudices ran unchecked and labor unrest all too easily led to homicide

Penggunaan Model Pembelajaran Discovery Learning untuk Meningkatkan Kemampuan Pemecahan Masalah pada Siswa SMP

—Penelitian ini bertujuan untuk melihat pengaruh penggunaan model pembelajaran Discovery Learning terhadap kemampuan pemecahan masalah matematis siswa SMP. Penelitian ini merupakan penelitian eksperimen. Populasi dalam penelitian ini adalah siswa kelas VIII, sedangkan sampel nya adalah siswa kelas VIII A sebagai kelas eksperimen dan VIII B sebagai kelas kontrol di SMP Islam Abata Malausma. Penelitian ini menggunakan desain penelitian The Nonequivalen Pretes-Postes Control Group Design. Populasi dalam penelitian ini adalah seluruh siswa kelas VIII SMP Islam Abata Malausma, Kecamatan Malausma Kabupaten Majalengka tahun ajaran 2018/2019. Sementara sampel kelas VIII A sebagai kelas eksperimen dan VIII B sebagai kelas kontrol. Hasil Penelitian disimpulkan sebagai berikut: (1) Penggunaan model pembelajaran discovery learning dapat meningkatkan kemampuan pemecahan masalah matematis siswa SMP kelas VIII dengan sangat baik. Hal ini dibuktikan dengan nilai rata-rata di akhir pembelajaran sebesar 54 dari skor maksimal 80 yang pada awalnya hanya memiliki rata-rata 5,44 dari skor maksimal 80; (2) Aktivitas siswa ketika pembelajaran menggunakan model discovery learning dalam memecahkan masalah matematika sebesar 80% pada kategori baik . Hal ini dibuktikan dengan peningkatan aktivitas siswa ketika pembelajaran sebesar 4 dari nilai maksimal 5 dan hal itu termasuk dalam kategori baik

First principles based atomistic modeling of phase stability in PMN-xPT

We have performed molecular dynamics simulations using a shell model potential developed by fitting first principles results to describe the behavior of the relaxor-ferroelectric (1-x)PbMg1/3Nb2/3O3-xPbTiO3 (PMN-xPT) as function of concentration and temperature, using site occupancies within the random site model. In our simulations, PMN is cubic at all temperatures and behaves as a polar glass. As a small amount of Ti is added, a weak polar state develops, but structural disorder dominates, and the symmetry is rhombohedral. As more Ti is added the ground state is clearly polar and the system is ferroelectric, but with easy rotation of the polarization direction. In the high Ti content region, the solid solution adopts ferroelectric behavior similar to PT, with tetragonal symmetry. The ground state sequence with increasing Ti content is R-MB-O-MC-T. The high temperature phase is cubic at all compositions. Our simulations give the slope of the morphotropic phase boundaries, crucial for high temperature applications. We find that the phase diagram PMN-xPT can be understood within the random site model.Comment: 27 pages, 9 figure

Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer.

Suppression of androgen receptor (AR) activity in prostate cancer by androgen depletion or direct AR antagonist treatment, although initially effective, leads to incurable castration-resistant prostate cancer (CRPC) via compensatory mechanisms including resurgence of AR and AR splice variant (ARV) signaling. Emerging evidence suggests that Sigma1 (also known as sigma-1 receptor) is a unique chaperone or scaffolding protein that contributes to cellular protein homeostasis. We reported previously that some Sigma1-selective small molecules can be used to pharmacologically modulate protein homeostasis pathways. We hypothesized that these Sigma1-mediated responses could be exploited to suppress AR protein levels and activity. Here we demonstrate that treatment with a small-molecule Sigma1 inhibitor prevented 5α- dihydrotestosterone-mediated nuclear translocation of AR and induced proteasomal degradation of AR and ARV, suppressing the transcriptional activity and protein levels of both full-length and splice-variant AR. Consistent with these data, RNAi knockdown of Sigma1 resulted in decreased AR levels and transcriptional activity. Furthermore, Sigma1 physically associated with ARV7 and A

Instruments Measuring Self-Care in Children and Young Adults With Chronic Conditions: A Systematic Review

: Children and young adults (CYAs) with chronic conditions need to engage in self-care to improve their quality of life. This study aimed to retrieve the literature on instruments to assess self-care in CYAs living with chronic conditions and evaluate the psychometric proprieties of the instruments retrieved. A systematic literature review was conducted on six databases to identify peer-reviewed papers that described or used an evaluation instrument of self-care in CYAs with chronic conditions. Twenty-three articles describing 11 instruments of self-care were identified. Five instruments (45.45%) were developed for specific diseases, while six (54.54%) for various chronic illnesses. Most of the instruments were focused on treatment adherence within self-care maintenance (i.e., behaviors to maintain illness stability), excluding the monitoring of clinical parameters or the management of exacerbations. This review provides an overview of available instruments that measure self-care in CYAs with chronic conditions, which health professionals could use for patient education

Complete Genome Sequences of Four Staphylococcus aureus Sequence Type 398 Isolates from Four Goats with Osteomyelitis

Staphylococcus aureus is the causative agent of multiple infections, including bacteremia, infective endocarditis, osteomyelitis, septic arthritis, and prosthetic device infections. We report here the first whole-genome sequence for four S. aureus sequence type 398 isolates from clinical cases of osteomyelitis in four goats with a history of orthopedic surgery