786 research outputs found
Poly[[[[1-ethyl-6,8-difluoro-7-(3-methylÂpiperazin-1-yl)-4-oxo-1,4-dihydroÂquinoline-3-carboxylÂato]cadmium]-ÎĽ-benzene-1,4-dicarboxylÂato] trihydrate]
In the title layered coordination polymer, {[Cd(C17H18F2N3O3)(C8H4O4)]·3H2O}n, the CdII atom exhibits a very distorted CdO6 octaÂhedral geometry defined by one O
3,O
4-bidentate 1-ethyl-6,8-difluoro-7-(3-methylÂpiperazin-1-yl)-4-oxo-1,4-dihydroÂquinoline-3-carboxylÂate (lome) ligand, one O,O′-bidentate benzene-1,4-dicarboxylÂate (bdc) dianion and two O-monodentate bdc dianions. Both the bdc species in the asymmetric unit are completed by crystallographic inversion symmetry. The bridging bdc dianions link the cadmium nodes into a rectaÂngular grid lying parallel to (01). A network of N—Hâ‹ŻO and O—Hâ‹ŻO hydrogen bonds helps to establish the packing
SIVcpz closely related to the ancestral HIV-1 is less or non-pathogenic to humans in a hu-BLT mouse model
The HIV-1 pandemic is a consequence of the cross-species transmission of simian immunodeficiency virus in wild chimpanzees (SIVcpz) to humans. Our previous study demonstrated SIVcpz strains that are closely related to the ancestral viruses of HIV-1 groups M (SIVcpzMB897) and N (SIVcpzEK505) and two SIVcpz lineages that are not associated with any known HIV-1 infections in humans (SIVcpzMT145 and SIVcpzBF1167), all can readily infect and robustly replicate in the humanized-BLT mouse model of humans. However, the comparative pathogenicity of different SIVcpz strains remains unknown. Herein, we compared the pathogenicity of the above four SIVcpz strains with HIV-1 using humanized-BLT mice. Unexpectedly, we found that all four SIVcpz strains were significantly less pathogenic or non-pathogenic compared to HIV-1, manifesting lower degrees of CD4+ T-cell depletion and immune activation. Transcriptome analyses of CD4+ T cells from hu-BLT mice infected with SIVcpz versus HIV-1 revealed enhanced expression of genes related to cell survival and reduced inflammation/immune activation in SIVcpz-infected mice. Together, our study results demonstrate for the first time that SIVcpz is significantly less or non-pathogenic to human immune cells compared to HIV-1. Our findings lay the groundwork for a possible new understanding of the evolutionary origins of HIV-1, where the initial SIVcpz crossspecies transmission virus may be initially less pathogenic to humans
NEURAL MARIONETTE: A Transformer-based Multi-action Human Motion Synthesis System
We present a neural network-based system for long-term, multi-action human
motion synthesis. The system, dubbed as NEURAL MARIONETTE, can produce
high-quality and meaningful motions with smooth transitions from simple user
input, including a sequence of action tags with expected action duration, and
optionally a hand-drawn moving trajectory if the user specifies. The core of
our system is a novel Transformer-based motion generation model, namely
MARIONET, which can generate diverse motions given action tags. Different from
existing motion generation models, MARIONET utilizes contextual information
from the past motion clip and future action tag, dedicated to generating
actions that can smoothly blend historical and future actions. Specifically,
MARIONET first encodes target action tag and contextual information into an
action-level latent code. The code is unfolded into frame-level control signals
via a time unrolling module, which could be then combined with other
frame-level control signals like the target trajectory. Motion frames are then
generated in an auto-regressive way. By sequentially applying MARIONET, the
system NEURAL MARIONETTE can robustly generate long-term, multi-action motions
with the help of two simple schemes, namely "Shadow Start" and "Action
Revision". Along with the novel system, we also present a new dataset dedicated
to the multi-action motion synthesis task, which contains both action tags and
their contextual information. Extensive experiments are conducted to study the
action accuracy, naturalism, and transition smoothness of the motions generated
by our system
Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage
Endogenous fibrinolysis might lead to hematoma progression in spontaneous intracerebral hemorrhage (ICH). We studied plasma biomarkers of fibrinolysis and hemostasis in twenty-two patients with ICH and nine healthy controls (HC) in a single-center study. Patients with ICH had significantly higher D-dimer and plasmin-alpha-2-antiplasmin complexes compared to HC. At baseline, patients with hematoma progression had higher urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA) and lower plasminogen levels, compared to those with no progression. 24-hour and day-7 matrix metalloproteinase-9 (MMP-9) was significantly increased in patients with hematoma progression
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