Case Study on the Enterprise Microblog Usage: Focusing on Knowledge Learning

Knowledge Management Strategy can be classified by codification strategy and personalization strategy (Hansen et. al., 1999), and how to manage the two strategies were always studied. Also, current studies regarding the knowledge management strategy were targeted mostly for major companies, resulting in lack of studies in how it can be applied on SMEs. This research, with the knowledge management strategy suited for SMEs, sets an Enterprise Microblog (EMB), and with the EMB applied on SMEs’ Knowledge Management Strategy, it is reviewed on the perspective of SMEs’ Codification and Personalization Strategies. Through the advanced research regarding Knowledge Management Strategy and EMB, the hypothesis is set that “Depending on the development of the company, the main application of EMB alters from Codification Strategy to Personalization Strategy.” To check the hypothesis, SME that have used the EMB called ‘Yammer’ was analyzed from the data of their foundation until today. The case study has implemented longitudinal analysis which divides the period when the EMBs were used into three stages and analyzes the contents. As the result of the study, this suggests a substantial implication regarding the application of Knowledge Management Strategy and its Knowledge Management System that is suitable for SME

Generalizations of -Subalgebras in BCK/BCI-Algebras Based on Point -Structures

The aim of this article is to obtain more general forms than the papers of (Jun et al. (2010); Jun et al. (in press)). The notions of -subalgebras of types , and are introduced, and the concepts of -support and -support are also introduced. Several related properties are investigated. Characterizations of -subalgebra of type are discussed, and conditions for an -subalgebra of type to be an -subalgebra of type are considered

Commutative Pseudo Valuations on BCK-Algebras

The notion of a commutative pseudo valuation on a BCK-algebra is introduced, and its characterizations are investigated. The relationship between a pseudo valuation and a commutative pseudo-valuation is examined

Quantum Optical Induced-Coherence Tomography by a Hybrid Interferometer

Quantum interferometry based on induced-coherence phenomena has demonstrated the possibility of undetected-photon measurements. Perturbation in the optical path of probe photons can be detected by interference signals generated by quantum mechanically correlated twin photons propagating through a different path, possibly at a different wavelength. To the best of our knowledge, this work demonstrates for the first time a hybrid-type induced-coherence interferometer that incorporates a Mach-Zehnder-type interferometer for visible photons and a Michelson-type interferometer for infrared photons, based on double-pass pumped spontaneous parametric down-conversion. This configuration enables infrared optical measurements via the detection of near-visible photons and provides methods for characterizing the quality of measurements by identifying photon pairs of different origins. The results verify that the induced-coherence interference visibility is approximately the same as the heralding efficiencies between twin photons along the relevant spatial modes. Applications to both time-domain and frequency-domain quantum-optical induced-coherence tomography for three-dimensional test structures are demonstrated. The results prove the feasibility of practical undetected-photon sensing and imaging techniques based on the presented structure

Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice

<p>Abstract</p> <p>Background</p> <p>Petroleum ether extracts of <it>Viola websteri </it>Hemsl (Violaceae) were reported to have anti-plasmodial activity against <it>Plasmodium falciparum in vitro</it>, with this activity being largely attributable to 6-(8'Z-pentadecenyl)-salicylic acid (6-SA).</p> <p>Methods</p> <p>The schizontocidal activity of 6-SA on early <it>Plasmodium berghei </it>infections was evaluated in a four-day test. The possible 'repository' activity of 6-SA was assessed using the method described by Peters. The median lethal dose (LD₅₀) of 6-SA, when given intraperitoneally, was also determined using uninfected ICR mice and the method of Lorke.</p> <p>Results</p> <p>In the present study, 6-SA was found to have anti-malarial activity <it>in vivo</it>, when tested against <it>P. berghei </it>in mice. 6-SA at 5, 10 and 25 mg/kg·day exhibited a significant blood schizontocidal activity in four-day early infections, repository evaluations and established infections with a significant mean survival time comparable to that of the standard drug, chloroquine (5 mg/kg·day).</p> <p>Conclusion</p> <p>6-SA possesses a moderate anti-malarial activity that could be exploited for malaria therapy.</p

Cyclic Loading Test of Structural Walls with Small Openings

This study aimed to investigate the effects of small openings on the structural performance of reinforced-concrete (RC) structural walls. Cyclic lateral loading tests were conducted on five RC walls with an aspect ratio of 2.6 and small openings. The main test parameter was the size of the small openings. The specimens were designed to fail after flexural yielding, considering the typical failure mode of slender RC walls. The structural performances of the test specimens were analyzed based on the test results in terms of the load-carrying capacity (flexural strength), hysteretic behavior, strain distribution, and the size of the openings. The specimens showed flexural yielding regardless of the size of the openings, and the flexural strength and deformation capacity were not significantly affected by the small openings. This result indicates that small openings do not affect the flexural behavior of slender walls if the walls have sufficient shear resistance and the small openings are located away from the extreme compressive end and in the compression zone where compressive stress does not decrease.This work was fnancially supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea Government (MSIT) (No. 2018R1A2B6007559

Microspinning: Local Surface Mixing via Rotation of Magnetic Microparticles for Efficient Small-Volume Bioassays

The need for high-throughput screening has led to the miniaturization of the reaction volume of the chamber in bioassays. As the reactor gets smaller, surface tension dominates the gravitational or inertial force, and mixing efficiency decreases in small-scale reactions. Because passive mixing by simple diffusion in tens of microliter-scale volumes takes a long time, active mixing is needed. Here, we report an efficient micromixing method using magnetically rotating microparticles with patterned magnetization induced by magnetic nanoparticle chains. Because the microparticles have magnetization patterning due to fabrication with magnetic nanoparticle chains, the microparticles can rotate along the external rotating magnetic field, causing micromixing. We validated the reaction efficiency by comparing this micromixing method with other mixing methods such as simple diffusion and the use of a rocking shaker at various working volumes. This method has the potential to be widely utilized in suspension assay technology as an efficient mixing strategy

Homeobox gene Dlx-2 is implicated in metabolic stress-induced necrosis

<p>Abstract</p> <p>Background</p> <p>In contrast to tumor-suppressive apoptosis and autophagic cell death, necrosis promotes tumor progression by releasing the pro-inflammatory and tumor-promoting cytokine high mobility group box 1 (HMGB1), and its presence in tumor patients is associated with poor prognosis. Thus, necrosis has important clinical implications in tumor development; however, its molecular mechanism remains poorly understood.</p> <p>Results</p> <p>In the present study, we show that Distal-less 2 (Dlx-2), a homeobox gene of the Dlx family that is involved in embryonic development, is induced in cancer cell lines dependently of reactive oxygen species (ROS) in response to glucose deprivation (GD), one of the metabolic stresses occurring in solid tumors. Increased Dlx-2 expression was also detected in the inner regions, which experience metabolic stress, of human tumors and of a multicellular tumor spheroid, an <it>in vitro </it>model of solid tumors. Dlx-2 short hairpin RNA (shRNA) inhibited metabolic stress-induced increase in propidium iodide-positive cell population and HMGB1 and lactate dehydrogenase (LDH) release, indicating the important role(s) of Dlx-2 in metabolic stress-induced necrosis. Dlx-2 shRNA appeared to exert its anti-necrotic effects by preventing metabolic stress-induced increases in mitochondrial ROS, which are responsible for triggering necrosis.</p> <p>Conclusions</p> <p>These results suggest that Dlx-2 may be involved in tumor progression via the regulation of metabolic stress-induced necrosis.</p

Racial differences in long-term social, physical, and psychological health among adolescent and young adult cancer survivors

Background The current guidelines for survivorship in adolescents and young adults (AYA) cancer are based on studies conducted in the United States and European AYA survivors. However, previous studies have shown that the health-related quality of life in cancer survivors can vary depending on race, yet the long-term health differences among AYA survivors by race/ethnicity have not been fully explored. Therefore, our aim is to compare the psychosocial and physical health of AYA survivors and their matched controls across different racial and ethnic groups. Methods We conducted a cross-sectional study using US National Health and Nutrition Examination Survey (NHANES) and the Korea NHANES from 2007 to 2018. We included AYA cancer survivors who were diagnosed with any type of cancer aged between 15 and 39 years, and who were adult with aged over 18 years old at survey year. We then stratified the study population by race/ethnicity with Non-Hispanic White (NHW, n = 310), African American (AA, n = 42), Hispanic (n = 81) from NHANES, and Asian (n = 389) from the Korea NHANES. We also selected 5 times age-, sex-, race-, and survey year-matched general population among participants who had never been diagnosed with cancer (N = 4110). Variables were defined using questionnaire data, physical exams, and laboratory tests. Results Compared to NHW, Hispanics (aOR 1.15, 95% CI 1.00–1.32) had poor or fair general health, lower education (aOR 1.23, 95% CI 1.07–1.40), and lower household income (aOR 1.16, 95% CI 1.01–1.33). AA survivors were more likely to be non-coupled (aOR 1.35, 95% 1.15–1.60) and have hypertension (aOR 1.18, 95% CI 1.03–1.36). Asians were more former/current drinkers (aOR 1.21, 95% CI 1.05–1.40). NHW are more likely to experience psychological limitation. Compared to matched general, NHW and Asian survivors had poor general health and psychological health. Conclusions This study provides evidence for future studies concerning long-term health after AYA cancer survivorship that may vary according to race.This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government (NRF-2022R1A2C1013119