7,347 research outputs found

    Fatigue in martensitic 100Cr6: Relationship between rolling contact fatigue microstructural transitions and repetitive push testing

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    Repetitive uniaxial fatigue testing is introduced to reproduce a similar magnitude of compressive stress to rolling contact during bearing operation, and to investigate the associated microstructural transitions. During the test, the strain per cycle responsible for fatigue damage can be measured. The observed hardness increase suggests that the developed residual stress level is similar to that formed on ball-on-rod bearing testing. The suggested methodology would be helpful in determining the strain responsible for plastic deformation in rolling contact fatigue, as well as for appraising the quality of bearing materials employed for bearing elements.This work was supported by SKF Engineering & Research Centre and ļ¬nanced by SKF ABThis is the author accepted manuscript. The final version is available from Elsevier at http://www.sciencedirect.com/science/article/pii/S0921509314008351. Ā© 2014 Elsevie

    Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation

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    The blood coagulation system of 66 consecutive patients undergoing consecutive liver transplantations was monitored by thrombelastograph and analytic coagulation profile. A poor preoperative coagulation state, decrease in levels of coagulation factors, progressive fibrinolysis, and whole blood clot lysis were observed during the preanhepatic and anhepatic stages of surgery. A further general decrease in coagulation factors and platelets, activation of fibrinolysis, and abrupt decrease in levels of factors V and VIII occurred before and with reperfusion of the homograft. Recovery of blood coagulability began 30-60 min after reperfusion of the graft liver, and coagulability had returned toward baseline values 2 hr after reperfusion. A positive correlation was shown between the variables of thrombelastography and those of the coagulation profile. Thrombelastography was shown to be a reliable and rapid monitoring system. Its use was associated with a 33% reduction of blood and fluid infusion volume, whereas blood coagulability was maintained without an increase in the number of blood product donors

    Enhancing 2D Growth of Organic Semiconductor Thin Films with Macroporous Structures via a Small-Molecule Heterointerface

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    The physical structure of an organic solid is strongly affected by the surface of the underlying substrate. Controlling this interface is an important issue to improve device performance in the organic electronics community. Here we report an approach that utilizes an organic heterointerface to improve the crystallinity and control the morphology of an organic thin film. Pentacene is used as an active layer above, and m-bis(triphenylsilyl) benzene is used as the bottom layer. Sequential evaporations of these materials result in extraordinary morphology with far fewer grain boundaries and myriad nanometre-sized pores. These peculiar structures are formed by difference in molecular interactions between the organic layers and the substrate surface. The pentacene film exhibits high mobility up to 6.3 cm(2)V(-1)s(-1), and the pore-rich structure improves the sensitivity of organic-transistor-based chemical sensors. Our approach opens a new way for the fabrication of nanostructured semiconducting layers towards high-performance organic electronics.X116049Nsciescopu

    Rolling contact fatigue in martensitic 100Cr6: Subsurface hardening and crack formation

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    Rolling contact fatigue tests on 100Cr6 steel were carried out with a ball-on-rod tester. Microstructural damage was manifested by gradual hardness changes under the subsurface, and microcracks formed adjacent to inclusions; both being evidence of plastic deformation. The hardness increase appears to be due to the development of residual stress, while the microcracks form as a result of the concentration of stress around inclusions. The microcrack orientation is suggested to be affected by the stress state, depending on the degree of residual stresses generated. The residual stress development may be a key factor for optimising the bearing element testing methods, by considering its influence on the damage morphology.This work was supported by SKF Engineering & Research Centre and financed by SKF AB.NOTICE: this is the authorā€™s version of a work that was accepted for publication in Materials Science and Engineering: A. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Materials Science and Engineering: A, Volume 607, 23 June 2014, Pages 328ā€“333. DOI: http://dx.doi.org/10.1016/j.msea.2014.03.143. http://www.sciencedirect.com/science/article/pii/S0921509314004365

    Regulation of Transgene Expression in Tumor Cells by Exploiting Endogenous Intracellular Signals

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    Recently, we have proposed a novel strategy for a cell-specific gene therapy system based on responses to intracellular signals. In this system, an intracellular signal that is specifically and abnormally activated in the diseased cells is used for the activation of transgene expression. In this study, we used protein kinase C (PKC)Ī± as a trigger to activate transgene expression. We prepared a PKCĪ±-responsive polymer conjugate [PPC(S)] and a negative control conjugate [PPC(A)], in which the phosphorylation site serine (Ser) was replaced with alanine (Ala). The phosphorylation for polymer/DNA complexes was determined with a radiolabel assay using [Ī³-32P]ATP. PPC(S)/DNA complexes were phosphorylated by the addition of PKCĪ±, but no phosphorylation of the PPC(A)/DNA complex was observed. Moreover, after microinjection of polymer/GFP-encoding DNA complexes into HepG2 cells at cation/anion (C/A) ratios of 0.5 to 2.0, significant expression of GFP was observed in all cases using PPC(S)/DNA complexes, but no GFP expression was observed in the negative control PPC(A)/DNA complex-microinjected cells at C/A ratios of 1.0 and 2.0. On the other hand, GFP expression from PPC(S)/DNA complexes was completely suppressed in cells pretreated with PKCĪ± inhibitor (Ro31-7549). These results suggest that our gene regulation system can be used for tumor cell-specific expression of a transgene in response to PKCĪ± activity

    Variation of structural, electrical, and optical properties of Zn <inf>1-x</inf>Mg <inf>x</inf>O thin films

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    Zn 1-xMg xO thin films on (001) sapphire substrates were deposited using pulsed laser deposition. As the substrate temperature increased, the Mg content in the Zn 1-xMg xO thin films increased and the photoluminescence (PL) peak position of the Zn 1-xMg xO thin films shifted from 370 to 356 nm, indicating a band gap expansion. Variations of the structural, electrical, and optical properties of Zn 1-xMgO thin films have been observed and analyzed by x-ray diffraction, Hall measurements, and PL measurements. Ā© 2006 American Institute of Physics

    Patterning of ferroelectric nanodot arrays using a silicon nitride shadow mask

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    We grew well-ordered arrays of ferroelectric Pb (Zr0.2 Ti0.8) O3 (PZT) nanodots on a SrRu O3 SrTi O3 substrate by pulsed laser deposition. A silicon nitride shadow mask with ordered holes was used for patterning of the PZT arrays. Each dot has a height of ???15 nm and a diameter of ???120 nm with a similar dome shape over a large area. The ferroelectric properties of individual PZT dots were investigated by piezoresponse force microscopy. A single dot could be polarized individually and the polarized state remained unrelaxed to ???20 min.open232
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