Interference during burning in air for nine stationary fuel droplets arranged in a body-centered cubic lattice

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Value-Based Business Process Reengineering : An Objective Approach to Value Added

The promise of business process reengineering (BPR) must be validated by its effect on the "bottom line." It will be taken seriously as a new process improvement framework only when executives can be assured, a priori, that it will produce the desired ROI特別寄

Electromagnetic showers in a strong magnetic field

We present the results concerning the main shower characteristics in a strong magnetic field obtained through shower simulation. The processes of magnetic bremsstrahlung and pair production were taken into account for values of the parameter $\chi \gg 1$. We compare our simulation results with a recently developed cascade theory in a strong magnetic field.Comment: 11 pages, 9 eps figures, LaTex2e, Iopart.cls, Iopart12.clo, Iopams.st

An information-theoretic approach to software test-retest problems

Symposium Presentation (for Acquisition Research Program)Symposium PresentationNaval Postgraduate School Acquisition Research ProgramApproved for public release; distribution is unlimited

Analysis of hepatitis C virus RNA dimerization and core–RNA interactions

The core protein of hepatitis C virus (HCV) has been shown previously to act as a potent nucleic acid chaperone in vitro, promoting the dimerization of the 3′-untranslated region (3′-UTR) of the HCV genomic RNA, a process probably mediated by a small, highly conserved palindromic RNA motif, named DLS (dimer linkage sequence) [G. Cristofari, R. Ivanyi-Nagy, C. Gabus, S. Boulant, J. P. Lavergne, F. Penin and J. L. Darlix (2004) Nucleic Acids Res., 32, 2623–2631]. To investigate in depth HCV RNA dimerization, we generated a series of point mutations in the DLS region. We find that both the plus-strand 3′-UTR and the complementary minus-strand RNA can dimerize in the presence of core protein, while mutations in the DLS (among them a single point mutation that abolished RNA replication in a HCV subgenomic replicon system) completely abrogate dimerization. Structural probing of plus- and minus-strand RNAs, in their monomeric and dimeric forms, indicate that the DLS is the major if not the sole determinant of UTR RNA dimerization. Furthermore, the N-terminal basic amino acid clusters of core protein were found to be sufficient to induce dimerization, suggesting that they retain full RNA chaperone activity. These findings may have important consequences for understanding the HCV replicative cycle and the genetic variability of the virus

Investigating knowledge management factors affecting Chinese ICT firms performance: An integrated KM framework

This is an Author's Accepted Manuscript of an article published in the Journal of Information Systems Management, 28(1), 19 - 29, 2011, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/10580530.2011.536107.This article sets out to investigate the critical factors of Knowledge Management (KM) which are considered to have an impact on the performance of Chinese information and communication technology (ICT) firms. This study confirms that the cultural environment of an enterprise is central to its success in the context of China. It shows that a collaborated, trusted, and learning environment within ICT firms will have a positive impact on their KM performance

Cognitive function in a randomized trial of evolocumab

Inga Stuķēna as well as a complete list of investigators is provided in the Supplementary Appendix, available at NEJM.org. https://www.nejm.org/doi/suppl/10.1056/NEJMoa1701131/suppl_file/nejmoa1701131_appendix.pdf Funding Information: (Funded by Amgen; EBBINGHAUS ClinicalTrials.gov number, NCT02207634.) Supported by Amgen. We thank Sarah T. Farias, Ph.D., at UC Davis Health for providing the English-language and translated versions of the Everyday Cognition (ECog) tool. Publisher Copyright: Copyright © 2017 Massachusetts Medical Society.BACKGROUND: Findings from clinical trials of proprotein convertase subtilisin–kexin type 9 (PCSK9) inhibitors have led to concern that these drugs or the low levels of low-density lipoprotein (LDL) cholesterol that result from their use are associated with cognitive deficits. METHODS: In a subgroup of patients from a randomized, placebo-controlled trial of evolocumab added to statin therapy, we prospectively assessed cognitive function using the Cambridge Neuropsychological Test Automated Battery. The primary end point was the score on the spatial working memory strategy index of executive function (scores range from 4 to 28, with lower scores indicating a more efficient use of strategy and planning). Secondary end points were the scores for working memory (scores range from 0 to 279, with lower scores indicating fewer errors), episodic memory (scores range from 0 to 70, with lower scores indicating fewer errors), and psychomotor speed (scores range from 100 to 5100 msec, with faster times representing better performance). Assessments of cognitive function were performed at baseline, week 24, yearly, and at the end of the trial. The primary analysis was a noninferiority comparison of the mean change from baseline in the score on the spatial working memory strategy index of executive function between the patients who received evolocumab and those who received placebo; the noninferiority margin was set at 20% of the standard deviation of the score in the placebo group. RESULTS: A total of 1204 patients were followed for a median of 19 months; the mean (±SD) change from baseline over time in the raw score for the spatial working memory strategy index of executive function (primary end point) was −0.21±2.62 in the evolocumab group and −0.29±2.81 in the placebo group (P<0.001 for noninferiority; P=0.85 for superiority). There were no significant between-group differences in the secondary end points of scores for working memory (change in raw score, −0.52 in the evolocumab group and −0.93 in the placebo group), episodic memory (change in raw score, −1.53 and −1.53, respectively), or psychomotor speed (change in raw score, 5.2 msec and 0.9 msec, respectively). In an exploratory analysis, there were no associations between LDL cholesterol levels and cognitive changes. CONCLUSIONS: In a randomized trial involving patients who received either evolocumab or placebo in addition to statin therapy, no significant between-group difference in cognitive function was observed over a median of 19 months.publishersversionPeer reviewe

Ultra-High Energy Gamma Rays in Geomagnetic Field and Atmosphere

The nature and origin of ultra-high energy (UHE: reffering to > 10^19 eV) cosmic rays are great mysteries in modern astrophysics. The current theories for their explanation include the so-called "top-down" decay scenarios whose main signature is a large ratio of UHE gamma rays to protons. Important step in determining the primary composition at ultra-high energies is the study of air shower development. UHE gamma ray induced showers are affected by the Landau-Pomeranchuk-Migdal (LPM) effect and the geomagnetic cascading process. In this work extensive simulations have been carried out to study the characteristics of air showers from UHE gamma rays. At energies above several times 10^19 eV the shower is affected by geomagnetic cascading rather than by the LPM effect. The properties of the longitudinal development such as average depth of the shower maximum or its fluctuations depend strongly on both primary energy and incident direction. This feature may provide a possible evidence of the UHE gamma ray presence by fluorescence detectors.Comment: 27 pages, 12 figures, submitted to Phys.Rev.

Space-VLBI observations of OH maser OH34.26+0.15: low interstellar scattering

We report on the first space-VLBI observations of the OH34.26+0.15 maser in two main line OH transitions at 1665 and 1667 MHz. The observations involved the space radiotelescope on board the Japanese satellite HALCA and an array of ground radio telescopes. The map of the maser region and images of individual maser spots were produced with an angular resolution of 1 milliarcsec which is several times higher than the angular resolution available on the ground. The maser spots were only partly resolved and a lower limit to the brightness temperature 6x10^{12} K was obtained. The maser seems to be located in the direction of low interstellar scattering, an order of magnitude lower than the scattering of a nearby extragalactic source and pulsar.Comment: 8 pages, 2 tables, 9 figures, accepted for publication in MNRA