When is an alternative possibility robust?

According to some, free will requires alternative possibilities. But not any old alternative possibility will do. Sometimes, being able to bring about an alternative does not bestow any control on an agent. In order to bestow control, and so be directly relevant qua alternative to grounding the agent's moral responsibility, alternatives need to be robust. Here, I investigate the nature of robust alternatives. I argue that Derk Pereboom's latest robustness criterion is too strong, and I suggest a different criterion based on the idea that what agents need to be able to do is keep open the possibility of securing their blamelessness, rather than needing to directly ensure their own blamelessness at the time of decision

Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery.

Adeno-associated viral (AAV) vectors, which are undergoing broad exploration in clinical trials, have significant promise for therapeutic gene delivery because of their safety and delivery efficiency. Gene delivery technologies capable of mediating localized gene expression may further enhance the potential of AAV in a variety of therapeutic applications by reducing spread outside a target region, which may thereby reduce off-target side effects. We have genetically engineered an AAV variant capable of binding to surfaces with high affinity through a hexa-histidine metal-binding interaction. This immobilized AAV vector system mediates high-efficiency delivery to cells that contact the surface and thus may have promise for localized gene delivery, which may aid numerous applications of AAV delivery to gene therapy

Finite difference time domain implementation of surface impedance boundary conditions

Surface impedance boundary conditions are employed to reduce the solution volume during the analysis of scattering from lossy dielectric objects. In a finite difference solution, they also can be utilized to avoid using small cells, made necessary by shorter wavelengths in conducting media throughout the solution volume. The standard approach is to approximate the surface impedance over a very small bandwidth by its value at the center frequency, and then use that result in the boundary condition. Two implementations of the surface impedance boundary condition are presented. One implementation is a constant surface impedance boundary condition and the other is a dispersive surface impedance boundary condition that is applicable over a very large frequency bandwidth and over a large range of conductivities. Frequency domain results are presented in one dimension for two conductivity values and are compared with exact results. Scattering width results from an infinite square cylinder are presented as a 2-D demonstration. Extensions to 3-D should be straightforward

Wideband finite difference time domain implementation of surface impedance boundary conditions for good conductors

Surface impedance boundary conditions are used to reduce the solution volume during the analysis of scattering from lossy dielectric objects. In a finite difference solution, they also can be used to avoid using small cells, made necessary by shorter wavelengths in conducting media, throughout the solution volume. A one dimensional implementation is presented for a surface impedance boundary condition for good conductors in the Finite Difference Time Domain (FDTD) technique. In order to illustrate the FDTD surface impedance boundary condition, a planar air-lossy dielectric interface is considered

High-Field Electrical Transport in Single-Wall Carbon Nanotubes

Using low-resistance electrical contacts, we have measured the intrinsic high-field transport properties of metallic single-wall carbon nanotubes. Individual nanotubes appear to be able to carry currents with a density exceeding 10^9 A/cm^2. As the bias voltage is increased, the conductance drops dramatically due to scattering of electrons. We show that the current-voltage characteristics can be explained by considering optical or zone-boundary phonon emission as the dominant scattering mechanism at high field.Comment: 4 pages, 3 eps figure

Is the PAMELA Positron Excess Winos?

Recently the PAMELA satellite-based experiment reported an excess of galactic positrons that could be a signal of annihilating dark matter. The PAMELA data may admit an interpretation as a signal from a wino-like LSP of mass about 200 GeV, normalized to the local relic density, and annihilating mainly into W-bosons. This possibility requires the current conventional estimate for the energy loss rate of positrons be too large by roughly a factor of five. Data from anti-protons and gamma rays also provide tension with this interpretation, but there are significant astrophysical uncertainties associated with their propagation. It is not unreasonable to take this well-motivated candidate seriously, at present, in part because it can be tested in several ways soon. The forthcoming PAMELA data on higher energy positrons and the FGST (formerly GLAST) data, should provide important clues as to whether this scenario is correct. If correct, the wino interpretation implies a cosmological history in which the dark matter does not originate in thermal equilibrium.Comment: 7 pages, 4 figue

Resonant Tunneling Between Quantum Hall Edge States

Resonant tunneling between fractional quantum Hall edge states is studied in the Luttinger liquid picture. For the Laughlin parent states, the resonance line shape is a universal function whose width scales to zero at zero temperature. Extensive quantum Monte Carlo simulations are presented for $\nu = 1/3$ which confirm this picture and provide a parameter-free prediction for the line shape.Comment: 14 pages , revtex , IUCM93-00

Disorder-Induced Multiple Transition involving Z2 Topological Insulator

Effects of disorder on two-dimensional Z2 topological insulator are studied numerically by the transfer matrix method. Based on the scaling analysis, the phase diagram is derived for a model of HgTe quantum well as a function of disorder strength and magnitude of the energy gap. In the presence of sz non-conserving spin-orbit coupling, a finite metallic region is found that partitions the two topologically distinct insulating phases. As disorder increases, a narrow-gap topologically trivial insulator undergoes a series of transitions; first to metal, second to topological insulator, third to metal, and finally back to trivial insulator. We show that this multiple transition is a consequence of two disorder effects; renormalization of the band gap, and Anderson localization. The metallic region found in the scaling analysis corresponds roughly to the region of finite density of states at the Fermi level evaluated in the self-consistent Born approximation.Comment: 5 pages, 5 figure

Low energy supersymmetry with a neutralino LSP and the CDF ee\gamma\gamma + missing E_T event

We present a refined and expanded analysis of the CDF ee\gamma\gamma + \Et event as superpartner production, assuming the lightest neutralino is the lightest supersymmetric particle. A general low-energy Lagrangian is constrained by a minimum cross section times branching ratio into two electrons and two photons, kinematics consistent with the event, and LEP1-LEP130 data. We examine how the supersymmetric parameters depend on the kinematics, branching ratios and experimental predictions with a selectron interpretation of the event, and discuss to what extent these are modified by other interpretations. Predictions for imminent CERN LEP upgrades and the present and future Fermilab Tevatron are presented. Finally, we briefly discuss the possible connection to other phenomena including a light stop, the neutralino relic density, the shift in $R_b$ and the associated shift in $\alpha_s$, and implications for the form of the theory.Comment: 57 pages, LaTeX, uses epsf.sty, 19 figures. Version accepted for publication in Phys. Rev. D, with minor changes and a few clarification

Do About Half the Top Quarks at FNAL Come From Gluino Decays?

We argue that it is possible to make a consistent picture of FNAL data including the production and decay of gluinos and squarks. The additional cross section is several pb, about the size of that for Standard Model (SM) top quark pair production. If the stop squark mass is small enough, about half of the top quarks decay to stop squarks, and the loss of SM top quark pair production rate is compensated by the supersymmetric processes. This behavior is consistent with the reported top quark decay rates in various modes and other aspects of the data, and suggests several other possible decay signatures. This picture can be tested easily with more data, perhaps even with the data in hand, and demonstrates the potential power of a hadron collider to determine supersymmetric parameters. It also has implications for the top mass measurement and the interpretation of the LEP $R_b$ excess.Comment: 18 pages, including 4 Postscript figures, uses epsf.tex, also available at http://www.hep.anl.gov/theory/mrenna