The Treatment and Outcome of Patients With Soft Tissue Sarcomas and Synchronous Metastases

Introduction: There is a strong association between poor overall survival and a short disease-free interval for patients with soft tissue sarcomas (STS) and metastatic disease. Patients with STS and synchronous metastases should have a very dismal prognosis.The role of surgery in this subgroup of patients with STS has not been defined

Practice patterns and outcomes of equivocal bone scans for patients with castration-resistant prostate cancer: Results from SEARCH.

ObjectiveTo review follow-up imaging after equivocal bone scans in men with castration resistant prostate cancer (CRPC) and examine the characteristics of equivocal bone scans that are associated with positive follow-up imaging.MethodsWe identified 639 men from five Veterans Affairs Hospitals with a technetium-99m bone scan after CRPC diagnosis, of whom 99 (15%) had equivocal scans. Men with equivocal scans were segregated into "high-risk" and "low-risk" subcategories based upon wording in the bone scan report. All follow-up imaging (bone scans, computed tomography [CT], magnetic resonance imaging [MRI], and X-rays) in the 3 months after the equivocal scan were reviewed. Variables were compared between patients with a positive vs. negative follow-up imaging after an equivocal bone scan.ResultsOf 99 men with an equivocal bone scan, 43 (43%) received at least one follow-up imaging test, including 32/82 (39%) with low-risk scans and 11/17 (65%) with high-risk scans (p = 0.052). Of follow-up tests, 67% were negative, 14% were equivocal, and 19% were positive. Among those who underwent follow-up imaging, 3/32 (9%) low-risk men had metastases vs. 5/11 (45%) high-risk men (p = 0.015).ConclusionWhile 19% of all men who received follow-up imaging had positive follow-up imaging, only 9% of those with a low-risk equivocal bone scan had metastases versus 45% of those with high-risk. These preliminary findings, if confirmed in larger studies, suggest follow-up imaging tests for low-risk equivocal scans can be delayed while high-risk equivocal scans should receive follow-up imaging

Effect of Volatile Boron Species on the Electrocatalytic Activity of Cathodes of Solid Oxide Fuel Cells: III. Ba0.5Sr0.5Co0.8Fe0.2O3-δ Electrodes

The effect of volatile boron species on the electrocatalytic activity, microstructure and phase stability of Ba0.5Sr0.5Co0.8Fe0.2O3-d (BSCF) cathodes has been studied. The cathodes were heat-treated at 800?C for 7 days in air in the presence of boron species vaporized from borosilicate glass, and were characterized by EIS, SEM, AFM, SIMS, XRD, XPS and ICP-OES. The results have shown that after the heat-treatment in the presence of borosilicate glass, boron deposition occurs mainly on the region near electrode surface, leading to the significant Ba and in particular Sr segregation, microstructure change and phase decomposition. On the other hand, the microstructure of the inner electrode layer is almost intact. Electrode polarization resistance, RE, of an as-prepared BSCF cathode is 0.93 and 0.23 Q cm2 at 650 and 800?C, respectively, and changes to 2.08 and 0.15 Q cm2 after heat-treatment at 800?C for 7 days in the presence of borosilicate glass, respectively. The increase in RE for the O2 reduction reaction on BSCF is much lower than that observed on La0.6Sr0.4Co0.2Fe0.8O3-d (LSCF) cathodes, indicating that BSCF cathodes have a much better tolerance toward boron deposition and poisoning. The limited attack of volatile boron species on BSCF is most likely related to the much slower kinetics of the formation of strontium and barium borates as compared to the formation of lanthanum borates. This study provides a significant insight into design and development of better contaminant-tolerant cathode materials for durable solid oxide fuel cell (SOFC) technologies

Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk

We have previously shown that injury-induced neointima formation was rescued by adenoviral-Nogo-B gene delivery. Integrase-competent lentiviral vectors (ICLV) are efficient at gene delivery to vascular cells but present a risk of insertional mutagenesis. Conversely, integrase-deficient lentiviral vectors (IDLV) offer additional benefits through reduced mutagenesis risk, but this has not been evaluated in the context of vascular gene transfer. Here, we have investigated the performance and genetic safety of both counterparts in primary human vascular smooth muscle cells (VSMC) and compared gene transfer efficiency and assessed the genotoxic potential of ICLVs and IDLVs based on their integration frequency and insertional profile in the human genome. Expression of enhanced green fluorescent protein (eGFP) mediated by IDLVs (IDLV-eGFP) demonstrated efficient transgene expression in VSMCs. IDLV gene transfer of Nogo-B mediated efficient overexpression of Nogo-B in VSMCs, leading to phenotypic effects on VSMC migration and proliferation, similar to its ICLV version and unlike its eGFP control and uninfected VSMCs. Large-scale integration site analyses in VSMCs indicated that IDLV-mediated gene transfer gave rise to a very low frequency of genomic integration compared to ICLVs, revealing a close-to-random genomic distribution in VSMCs. This study demonstrates for the first time the potential of IDLVs for safe and efficient vascular gene transfer

Plastic strain arrangement in copper single crystals in sliding

Deformation of tribologically loaded contact zone is one of the wear mechanisms in spite of the fact that no mass loss may occur during this process. Generation of optimal crystallographic orientations of the grains in a polycrystalline materials (texturing) may cause hardening and reducing the deformation wear. To reveal the orientation dependence of an individual gain and simplify the task we use copper single crystals with the orientations of the compression axis along [11 1] and [110]. The plastic deformation was investigated by means of optical, scanning electron microscopy and EBSD techniques. It was established that at least four different zones were generated in the course of sliding test, such as non-deformed base metal, plastic deformation layer sliding, crystalline lattice reorientation layer and subsurface grain structure layer. The maximum plastic strain penetration depth was observed on [110]-single crystals. The minimum stability of [11 1]-crystals with respect to rotation deformation mode as well as activation of shear in the sliding contact plane provide for rotation deformation localization below the worn surface. The high-rate accumulation of misorientations and less strain penetration depth was observed on [11 1]-crystals as compared to those of [110]-oriented ones

Luttinger Parameter g for Metallic Carbon Nanotubes and Related Systems

The random phase approximation (RPA) theory is used to derive the Luttinger parameter g for metallic carbon nanotubes. The results are consistent with the Tomonaga-Luttinger models. All metallic carbon nanotubes, regardless if they are armchair tubes, zigzag tubes, or chiral tubes, should have the same Luttinger parameter g. However, a (10,10) carbon peapod should have a smaller g value than a (10,10) carbon nanotube. Changing the Fermi level by applying a gate voltage has only a second order effect on the g value. RPA theory is a valid approach to calculate plasmon energy in carbon nanotube systems, regardless if the ground state is a Luttinger liquid or Fermi liquid. (This paper was published in PRB 66, 193405 (2002). However, Eqs. (6), (9), and (19) were misprinted there.)Comment: 2 figure

Essays on Western History in Honor of Elwyn B. Robinson

This book was published on the occasion of the retirement of Dr. Elwyn B. Robinson from the Department of History at the University of North Dakota. It features articles by several different historians regarding various subjects in the history of the American West.https://commons.und.edu/und-books/1021/thumbnail.jp

Number of Unfavorable Intermediate‐Risk Factors Predicts Pathologic Upstaging and Prostate Cancer‐Specific Mortality Following Radical Prostatectomy: Results From the SEARCH Database

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135480/1/pros23255.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135480/2/pros23255_am.pd

SIISP: Self-Efficacy Intervention to Improve STEM Performance [Poster]

Poster presented at the 2018 STEMM Equality Congress in Amsterdam, October 11-12, 2018. OBJECTIVES: • Develop, test, document, and disseminate a practical,scalable intervention to increase self-efficacy in university STEM students. • Develop and validate an efficient instrument for measuring university STEM self-efficacy, growth mindset, and perceived academic control in university STEM students. • Improve our understanding of the dynamics of self-efficacy— the factors that lead to growth, especially for traditionally under-represented, at-risk demographic groups