Amlodipine drug therapeutic failure: a rare case report

Drug Therapeutic failure is a rare condition which is underreported in recent scenario. It is important for the chronic diseases like Hypertension where it could lead to fatal outcome. In our case report elderly male patient taking tablet Amlodipine once daily as antihypertensive medication and had 2 years without any events. Patient came to the emergency department with the complaint of altered sensorium and elevated blood pressure. The mechanism for sudden increase in blood pressure (Decreased Therapeutic Response) in patient with ongoing treatment with amlodipine could be due to sympathetic over activity (e.g. stress), pharmacokinetic variation or counterfeit drug

RP-HPLC Method Development and Validation of Pazufloxacin in Their Bulk and Formulation

The present work was the development of a simple, efficient, and reproducible reverse-phase high performance liquid chromatographic (RP-HPLC) method for determination of Pazufloxacin (PFX) in bulk and its injection dosage form. The solvent system and wavelength were optimized in order to maximize the sensitivity of the proposed method and detection wavelength was carried out at 249 nm. The separation was achieved on HPLC binary gradient system equipped with HPLC 3000 series UV detector and Agilent Zorbax column C18 (4.6mm×50mm×5µm). The optimized mobile phase composition was methanol: phosphate buffer pH 4 (50:50%v/v). The separation of PFX was carried out on Kromasil C-18 (250 × 4.6 mm×5 ????m) column using phosphate buffer pH 4 and methanol by linear gradient program. Flow rate was 1.0 ml/min with a column temperature of 30?C. The method was validated in terms of accuracy, precision, linearity, LOD & LOQ of sample solution as per ICH guidelines. Linearity was observed in the concentration range of 5-25 ?g/ml & gave mean correlation coefficient 0.998. The developed RP-HPLC method was found to be accurate, precise and was successful applied to a Pazufloxacin bulk powder and its marketed formulation for qualitative estimation of Pazufloxacin

Design And Development Of Transition Autopilot For Vtol Uav

UAV becomes versatile in nature in terms of application and its compact operation. UAV has its own limits by its design nature. Fixed wing vehicles have high endurance and range where as multi-copter have hovering andvarious terrain operation. This briefs attempts to blend the combination of both fixed-wing and multi-copter and develops autonomous for transition. The conceptual design made with 1kg payload, 1km range, and 16 minute endurance with VTOL capability. The airframe is selected based on the requirements. The propulsion system designed such a way to adopt hover as well as cruise mode operation. The centre of gravity is fixed such a way to maintain during cruise, hover as well as transition. The autopilot is developed for smooth transition of hover to cruise and cruise to hover

Amlodipine drug therapeutic failure: a rare case report

Drug Therapeutic failure is a rare condition which is underreported in recent scenario. It is important for the chronic diseases like Hypertension where it could lead to fatal outcome. In our case report elderly male patient taking tablet Amlodipine once daily as antihypertensive medication and had 2 years without any events. Patient came to the emergency department with the complaint of altered sensorium and elevated blood pressure. The mechanism for sudden increase in blood pressure (Decreased Therapeutic Response) in patient with ongoing treatment with amlodipine could be due to sympathetic over activity (e.g. stress), pharmacokinetic variation or counterfeit drug