Data Warehousing Modernization: Big Data Technology Implementation

Considering the challenges posed by Big Data, the cost to scale traditional data warehouses is high and the performances would be inadequate to meet the growing needs of the volume, variety and velocity of data. The Hadoop ecosystem answers both of the shortcomings. Hadoop has the ability to store and analyze large data sets in parallel on a distributed environment but cannot replace the existing data warehouses and RDBMS systems due to its own limitations explained in this paper. In this paper, I identify the reasons why many enterprises fail and struggle to adapt to Big Data technologies. A brief outline of two different technologies to handle Big Data will be presented in this paper: Using IBM’s Pure Data system for analytics (Netezza) usually used in reporting, and Hadoop with Hive which is used in analytics. Also, this paper covers the Enterprise architecture consisting of Hadoop that successful companies are adapting to analyze, filter, process, and store the data running along a massively parallel processing data warehouse. Despite, having the technology to support and process Big Data, industries are still struggling to meet their goals due to the lack of skilled personnel to study and analyze the data, in short data scientists and data statisticians

Unique magnetic coupling between Mn doped stannaspherenes Mn @Sn12

We report the density functional theory based study of the interaction between two Mn doped stannaspherenes (Mn@Sn12). The calculated results show that Mn@Sn12cluster is not only highly stable and carry a high magnetic moment, but these clusters retain their structural identity and form a stable dimer cluster. Most importantly, the magnetic coupling between the Mn@Sn12clusters depends on the relative orientation of the cages. In addition, ab initiomolecular dynamics calculations show that the dimer cluster is stable at room temperature. These results are expected to trigger further investigations on highly stable bimetallic magnetic cage complexes

Pulmonary Patency Stent

Patients with malignancies in the central airways often experience significant breathing difficulties due to occlusion of the airways. One common palliative treatment option for this is a stent placement procedure. While patients often experience immediate symptom relief, long term use can result in the formation of granulation tissue, causing restenosis of the airway. The objective of this project is to design and prototype a modification to the Boston Scientific Ultraflex partially-covered stent in order to reduce granulation tissue and maintain airway patency. Deliverables include the detailed design, a working prototype, and supporting data. The main product specifications include effectiveness in reducing granulation, coating adhesion, and stent stability. The final design for this product consists of a paclitaxel-SIBS coating placed at the uncovered ends of the stent by using a dip coating method. This coating was tested in many ways, including for its effectiveness in reducing cell attachment, release kinetics, coating stability, and cytotoxicity. This testing has shown that the SIBS-paclitaxel coating is effective in reducing cell attachment in-vitro, the coating is stably adhered onto the stent in a moving environment, and that paclitaxel is steadily released from the coating. These results are very promising for future in-vivo studies.https://scholarscompass.vcu.edu/capstone/1077/thumbnail.jp

Structure and bonding of Au5M (M=Na, Mg, Al, Si, P, and S) clusters

The atomic and electronic structure of Au5M (M=Na, Mg, Al, Si, P, S, and Au) clusters have been investigated using generalized gradient approximation to the density functional theory. Depending on the nature of interaction with different impurity elements a structural transition from planar to nonplanar configuration has been observed in Au5M. With the exception of S, impurities with p electrons (Al, Si, P) yield nonplanar geometries of Au5M clusters, while those with selectrons (Na, Mg) yield planar geometries. The properties of Au5Scluster are anomalous: The cluster not only has a planar geometry, but also is chemically most stable with the highest vertical ionization potential among all the clusters studied. The origin of these anomalous properties of Au5S cluster is attributed to the delocalization of electronic wave function associated with the highest occupied molecular orbital

Hydrogen storage and the 18-electron rule

We show that the 18-electron rule can be used to design new organometallic systems that can store hydrogen with large gravimetric density. In particular, Ti containing organic molecules such as C4H4, C5H5, and C8H8 can store up to 9wt% hydrogen, which meets the Department of Energy target for the year 2015. More importantly, hydrogen in these materials is stored in molecular form with an average binding energy of about 0.55eV∕H2 molecule, which is ideal for fast kinetics. Using molecular orbitals we have analyzed the maximum number of H2 molecules that can be adsorbed as well as the nature of their bonding and orientation. The charge transfer from the H2 bonding orbital to the empty dxy and dx2−y2 orbitals of Ti has been found to be singularly responsible for the observed binding of the hydrogen molecule. It is argued that early transition metals are better suited for optimal adsorption/desorption of hydrogen

Reactivity of neutral and charged B13 clusters with O2: A theoretical study

The chemical reactivity of neutral, cationic, and anionic species of the gas phase B13 cluster with molecular oxygen, O2, was investigated using density functional theory. All three species of B 13 interact with an oxygen molecule to generate a variety of stable isomers, with those representing a dissociative chemisorption process forming the most stable configurations. Our results also show site-specific bonding of oxygen to the B13(+/0/-) cluster. The effect of sequential ionization on the formation of products is pronounced. In ionic B13 clusters, in addition to energetics, the spin of the reactants and products plays a vital role in determining the most favorable product channel. In addition, this study reveals a richness of phenomena requiring a unified consideration of energy, geometry, spin conversion, and details of the electronic structure not previously illustrated for the reactivity of boron clusters. © 2010 American Institute of Physics

Ferromagnetism in Al1−xCrxN thin films by density functional calculations

We report the results of a theoretical study of magnetic coupling between Cr atoms doped in bulk AlN as well as AlN (112¯0) thin films having wurtzite structure. The calculations are based on density fuctional theory with the generalized gradient approximation to the exchange and correlation potential. In the thin film, modeled by a slab of finite thickness, Cr atoms are found to cluster around N on the surface layer and couple ferromagnetically. The results for the Cr-doped AlN crystal are similar, namely, Cr atoms cluster around N and couple ferromagnetically. In the thin film, the preference of Cr to occupy surface sites over the bulk sites is shown to be due to reduced coordination of the surface atoms. As the distance between the Cr atoms increases, both the ferro- and antiferromagnetic states become energetically degenerate and this degeneracy may account for the observed low magnetic moment per Cr atom

Photoelectron spectroscopic study of iron-pyrene cluster anions

Iron-pyrene cluster anions, [Fem(pyrene)n]− (m = 1–2, n = 1–2) were studied in the gas phase by photoelectron spectroscopy, resulting in the determination of their electron affinity and vertical detachment energy values. Density functional theory calculations were also conducted, providing the structures and spin multiplicities of the neutral clusters and their anions as well as their respective electron affinity and vertical detachment energy values. The calculated magnetic moments of neutral Fe1(pyrene)1 and Fe2(pyrene)1 clusters suggest that a single pyrene molecule could be a suitable template on which to deposit small iron clusters, and that these in turn might form the basis of an iron cluster-based magnetic material. A comparison of the structures and corresponding photoelectron spectra for the iron-benzene, iron-pyrene, and iron-coronene cluster systems revealed that pyrene behaves more similarly to coronene than to benzene

Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment.

Ras/MAPK pathway signaling is a major participant in neurodevelopment, and evidence suggests that BRAF, a key Ras signal mediator, influences human behavior. We studied the role of the mutation BRAFQ257R, the most common cause of cardiofaciocutaneous syndrome (CFC), in an induced pluripotent stem cell (iPSC)-derived model of human neurodevelopment. In iPSC-derived neuronal cultures from CFC subjects, we observed decreased p-AKT and p-ERK1/2 compared to controls, as well as a depleted neural progenitor pool and rapid neuronal maturation. Pharmacological PI3K/AKT pathway manipulation recapitulated cellular phenotypes in control cells and attenuated them in CFC cells. CFC cultures displayed altered cellular subtype ratios and increased intrinsic excitability. Moreover, in CFC cells, Ras/MAPK pathway activation and morphological abnormalities exhibited cell subtype-specific differences. Our results highlight the importance of exploring specific cellular subtypes and of using iPSC models to reveal relevant human-specific neurodevelopmental events