7 research outputs found
Deprotonative Coupling of Pyridines with Aldehydes Catalyzed by an HMDS-Amide Base Generated <i>in Situ</i>
Copper-Catalyzed Intramolecular Olefinic C(sp<sup>2</sup>)–H Amidation for the Synthesis of <i>γ</i>-Alkylidene-<i>γ</i>-lactams
Herein, we report the copper-catalyzed dehydrogenative C(sp2)–N bond formation of 4-pentenamides via nitrogen-centered radicals. This reaction provides a straightforward and efficient preparation method for γ-alkylidene-γ-lactams. Notably, we could controllably synthesize α,β-unsaturated- or α,β-saturated-γ-alkylidene-γ-lactams depending on the reaction conditions
Copper-Catalyzed sp<sup>3</sup> C–H Aminative Cyclization of 2‑Alkyl‑<i>N</i>‑arylbenzamides: An Approach for the Synthesis of <i>N</i>‑Aryl-isoindolinones
The
synthesis of isoindolinones via copper-catalyzed sp<sup>3</sup> C–H
functionalization of 2-alkyl-<i>N</i>-substituted
benzamides is described. This process does not require the preparation
of halogenated substitutes, expensive transition metals, or toxic
Sn or CO gas. This method provides an efficient approach to generate
various functionalized isoindolinones
Tetramethylammonium Fluoride Tetrahydrate-Mediated Transition Metal-Free Coupling of Aryl Iodides with Unactivated Arenes in Air
Generation and Characterization of Anti-phenyl Sulfate Monoclonal Antibodies and a Potential Use for Phenyl Sulfate Analysis in Human Blood
Deprotonative Silylation of Aromatic C–H Bonds Mediated by a Combination of Trifluoromethyltrialkylsilane and Fluoride
A method for the deprotonative silylation
of aromatic C–H bonds has been developed using trifluoromethyltrimethylsilane
(CF<sub>3</sub>SiMe<sub>3</sub>, Ruppert–Prakash reagent) and
a catalytic amount of fluoride. In this reaction, CF<sub>3</sub>SiMe<sub>3</sub> is considered to act as a base and a silicon electrophile.
This process is highly tolerant to various functional groups on heteroarenes
and benzenes. Furthermore, this method can be applied to the synthesis
of trimethylsilyl group-containing analogs of TAC-101, which is a
bioactive synthetic retinoid with selective affinity for retinoic
acid receptor α (RAR-α) binding. We also report further
transformations of the silylated products into useful derivatives