A Performer's Guide to John Musto's Penelope: A Cycle of Seven Songs for Soprano and Piano

Award-winning composer John Musto stands at the forefront of modern American art-song composition. Many of his songs, such as "Litany" from Shadow of the Blues, have already achieved a place in the standard contemporary repertory for singers. His compositional technique weaves influences of jazz, blues, ragtime, and popular music with classical technique to make music that is decidedly modern but accessible and well liked both by critics and audiences. Unfortunately, though he is still actively composing, very little has been written about Musto and there is a lack of information available about his more recent compositions. This performance guide addresses one of Musto's acclaimed song cycles, Penelope, (a cycle of seven songs for soprano and piano) commissioned and premiered in 2000. The story of the cycle is an updated version of the character Penelope from Homer's The Odyssey and was a collaboration between Musto and poet Denise Lanctot. Including interviews with Musto, and his wife, soprano Amy Burton, who premiered the cycle and for whom it was written, the document provides background information on how the cycle was conceived and gives in-depth performance information on each of the seven songs of Penelope. In addition to musical examples and poetry from the songs, this study also contains a catalogue of Musto's compositions listing premiere dates, performers, and information about the commission of each work

Ensemble Concerts

A appreciation concert for Bill and Margot Winspear performed at the UNT College of Music Winspear Hall

Segmentation of Cerebrovascular Pathologies in Stroke Patients with Spatial and Shape Priors

We propose and demonstrate an inference algorithm for the automatic segmentation of cerebrovascular pathologies in clinical MR images of the brain. Identifying and differentiating pathologies is important for understanding the underlying mechanisms and clinical outcomes of cerebral ischemia. Manual delineation of separate pathologies is infeasible in large studies of stroke that include thousands of patients. Unlike normal brain tissues and structures, the location and shape of the lesions vary across patients, presenting serious challenges for prior-driven segmentation. Our generative model captures spatial patterns and intensity properties associated with different cerebrovascular pathologies in stroke patients. We demonstrate the resulting segmentation algorithm on clinical images of a stroke patient cohort.NIH (Grants 1K25EB013649-01, NAC-P41EB015902, U54-EB005149, NS082285, K23NS064052 and U01NS069208

17q25 locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status

Background and Purpose-Recently, a novel locus at 17q25 was associated with white matter hyperintensities (WMH) on MRI in stroke-free individuals. We aimed to replicate the association with WMH volume (WMHV) in patients with ischemic stroke. If the association acts by promoting a small vessel arteriopathy, it might be expected to also associate with lacunar stroke. Methods-We quantified WMH on MRI in the stroke-free hemisphere of 2588 ischemic stroke cases. Association between WMHV and 6 single-nucleotide polymorphisms at chromosome 17q25 was assessed by linear regression. These singlenucleotide polymorphisms were also investigated for association with lacunar stroke in 1854 cases and 51 939 stroke-free controls from METASTROKE. Meta-analyses with previous reports and a genetic risk score approach were applied to identify other novel WMHV risk variants and uncover shared genetic contributions to WMHV in community participants without stroke and ischemic stroke. Results-Single-nucleotide polymorphisms at 17q25 were associated with WMHV in ischemic stroke, the most significant being rs9894383 (P=0.0006). In contrast, there was no association between any single-nucleotide polymorphism and lacunar stroke. A genetic risk score analysis revealed further genetic components to WMHV shared between community participants without stroke and ischemic stroke. Conclusions-This study provides support for an association between the 17q25 locus and WMH. In contrast, it is not associated with lacunar stroke, suggesting that the association does not act by promoting small-vessel arteriopathy or the same arteriopathy responsible for lacunar infarction. © 2013 American Heart Association, Inc