The role of the salience network in cognitive and affective deficits

Analysis and interpretation of studies on cognitive and affective dysregulation often draw upon the network paradigm, especially the Triple Network Model, which consists of the default mode network (DMN), the frontoparietal network (FPN), and the salience network (SN). DMN activity is primarily dominant during cognitive leisure and self-monitoring processes. The FPN peaks during task involvement and cognitive exertion. Meanwhile, the SN serves as a dynamic “switch” between the DMN and FPN, in line with salience and cognitive demand. In the cognitive and affective domains, dysfunctions involving SN activity are connected to a broad spectrum of deficits and maladaptive behavioral patterns in a variety of clinical disorders, such as depression, insomnia, narcissism, PTSD (in the case of SN hyperactivity), chronic pain, and anxiety, high degrees of neuroticism, schizophrenia, epilepsy, autism, and neurodegenerative illnesses, bipolar disorder (in the case of SN hypoactivity). We discuss behavioral and neurological data from various research domains and present an integrated perspective indicating that these conditions can be associated with a widespread disruption in predictive coding at multiple hierarchical levels. We delineate the fundamental ideas of the brain network paradigm and contrast them with the conventional modular method in the first section of this article. Following this, we outline the interaction model of the key functional brain networks and highlight recent studies coupling SN-related dysfunctions with cognitive and affective impairments

Empathic Responses for Pain in Facial Muscles Are Modulated by Actor’s Attractiveness and Gender, and Perspective Taken by Observer

Although empathy for pain is an often studied phenomenon, only few studies employing electromyography (EMG) have investigated either emotional responses to the pain of others or factors that modulate these responses. The present study investigated whether the sex and attractiveness of persons experiencing pain affected muscle activity associated with empathy for pain, the corrugator supercili (CS) and orbicularis oculi (OO) muscles, in male and female participants in two conditions: adopting a perspective of “the other” or “the self.” Fifty one participants (27 females) watched movies showing situations that included the expression of pain, with female and male and more and less attractive actors under both conditions, while the CS and OO EMG were recorded. Perspective did not affect CS muscle activity, but OO muscle activity tended to be higher in women than men under the imagine-self condition. CS muscle activity, but not OO muscle activity, was modulated by the actors’ gender and attractiveness. CS muscle activity was stronger in response to the pain of less attractive than more attractive actors, and to the pain of female actors compared to male actors. Moreover, a positive correlation was found between empathic concern, as a trait, and CS muscle activity, but only in the imagine-self condition

Psychometric properties of the Polish adaptation of short form of the Empathy Quotient (EQ-Short)

Aim. The purpose of the present study was to analyze the psychometric properties of the Polish-language version of the EQ-Short questionnaire, designed to measure affective and cognitive empathy. Method. 940 subjects, aged 15-80, took part in the study. Subjects fluent in both Polish and English (N = 31) completed the questionnaire in the original English version and its Polish translation. The remaining subjects (N = 909) participated in a study designed to verify construct validity and reliability of the Polish version of the tool. Results. The Polish and English versions of the EQ-Short show linguistic equivalence at a satisfactory level (r = 0.80, p < 0.001). Tests of validity and reliability of the translated tool showed that the Polish-language EQ-Short has good psychometric properties (Cronbach’s α = 0.78), comparable to the original version. In all age groups there were statistically significant sex differences in EQ-Short scores: women scored higher than men. Conclusion. The Polish-language adaptation of EQ-Short is linguistically and psychometrically similar to the English original and meets the criteria of a reliable tool for measuring empathy

Empathy gap – what do we know about empathizing with others′ pain?

Empathy of pain as a multi-dimensional process includes sharing and understanding the pain of others in relation to oneself. Subjects in such studies are typically members of western, educated, industrialized, rich and democratic societies. In the literature review that we conducted, we observed that little is known about the empathy for pain in people who are not members of societies with these cultural characteristics. We often understand those who are “similar” to us more easily – ones who belong to “our” cultural circle. However, contact with another culture could help prevent such bias. Group characteristics, such as focus on others, hierarchy preference, or cultural differences in self-constructs, can change the activity of brain regions associated with empathy and compassion. Increasing the diversity of the research participants connected with education level, poverty, industrialization, and respect for basic citizen freedoms seem to be necessary to fully understand the mechanisms that influence the development and operation of empathy

Neural Correlates of Facial Mimicry: Simultaneous Measurements of EMG and BOLD Responses during Perception of Dynamic Compared to Static Facial Expressions

Facial mimicry (FM) is an automatic response to imitate the facial expressions of others. However, neural correlates of the phenomenon are as yet not well established. We investigated this issue using simultaneously recorded EMG and BOLD signals during perception of dynamic and static emotional facial expressions of happiness and anger. During display presentations, BOLD signals and zygomaticus major (ZM), corrugator supercilii (CS) and orbicularis oculi (OO) EMG responses were recorded simultaneously from 46 healthy individuals. Subjects reacted spontaneously to happy facial expressions with increased EMG activity in ZM and OO muscles and decreased CS activity, which was interpreted as FM. Facial muscle responses correlated with BOLD activity in regions associated with motor simulation of facial expressions [i.e., inferior frontal gyrus, a classical Mirror Neuron System (MNS)]. Further, we also found correlations for regions associated with emotional processing (i.e., insula, part of the extended MNS). It is concluded that FM involves both motor and emotional brain structures, especially during perception of natural emotional expressions

Physical attractiveness and sex as modulatory factors of empathic brain responses to pain

Empathy is a process that comprises affective sharing, imagining, and understanding the emotions and mental states of others. The brain structures involved in empathy for physical pain include the anterior insula (AI), and the anterior cingulate cortex (ACC). High empathy may lead people to undertake pro-social behaviour. It is important to understand how this process can be changed, and what factors these empathic responses depend on. Physical attractiveness is a major social and evolutional cue, playing a role in the formation of interpersonal evaluation. The aim of the study was to determine how attractiveness affects the level of empathy both in relation to self-rated behaviour and in terms of activation of specific empathy-related brain regions. Twenty-seven subjects (14 female and 13 male) were studied using fMRI method while they were watching short video scenes involving physically more and less attractive men and women who exhibited pain responses. In the absence of behavioural effects in compassion ratings, we observed stronger activation in empathic brain structures (ACC; AI) for less attractive men and for attractive women than for attractive men. Evolutionary psychology studies suggest that beauty is valued more highly in females than males, which might lead observers to empathize more strongly with the attractive woman than the men. Attractive mens’ faces are typically associated with enhanced masculine facial characteristics and are considered to possess fewer desirable personality traits compared with feminized faces. This could explain why more empathy was shown to less attractive men. In conclusion, the study showed that the attractiveness and sex of a model are important modulators of empathy for pain

Emotional Empathy and Facial Mimicry for Static and Dynamic Facial Expressions of Fear and Disgust

Facial mimicry is the tendency to imitate the emotional facial expressions of others. Increasing evidence suggests that the perception of dynamic displays leads to enhanced facial mimicry, especially for happiness and anger. However, little is known about the impact of dynamic stimuli on facial mimicry for fear and disgust. To investigate this issue, facial EMG responses were recorded in the corrugator supercilii, levator labii and lateral frontalis muscles, while participants viewed static (photos) and dynamic (videos) facial emotional expressions. Moreover, we tested whether emotional empathy modulated facial mimicry for emotional facial expressions.In accordance with our predictions, the highly empathic group responded with larger activity in the corrugator supercilii and levator labii muscles. Moreover, dynamic compared to static facial expressions of fear revealed enhanced mimicry in the high-empathic group in the frontalis and corrugator supercilii muscles. In the low-empathic group the facial reactions were not differentiated between fear and disgust for both dynamic and static facial expressions.We conclude that highly empathic subjects are more sensitive in their facial reactions to the facial expressions of fear and disgust compared to low empathetic counterparts. Our data confirms that personal characteristics, i.e. empathy traits as well as modality of the presented stimuli, modulate the strength of facial mimicry. In addition, measures of EMG activity of the levator labii and frontalis muscles may be a useful index of empathic responses of fear and disgust

Do Dynamic Compared to Static Facial Expressions of Happiness and Anger Reveal Enhanced Facial Mimicry?

<div><p>Facial mimicry is the spontaneous response to others’ facial expressions by mirroring or matching the interaction partner. Recent evidence suggested that mimicry may not be only an automatic reaction but could be dependent on many factors, including social context, type of task in which the participant is engaged, or stimulus properties (dynamic vs static presentation). In the present study, we investigated the impact of dynamic facial expression and sex differences on facial mimicry and judgment of emotional intensity. Electromyography recordings were recorded from the corrugator supercilii, zygomaticus major, and orbicularis oculi muscles during passive observation of static and dynamic images of happiness and anger. The ratings of the emotional intensity of facial expressions were also analysed. As predicted, dynamic expressions were rated as more intense than static ones. Compared to static images, dynamic displays of happiness also evoked stronger activity in the zygomaticus major and orbicularis oculi, suggesting that subjects experienced positive emotion. No muscles showed mimicry activity in response to angry faces. Moreover, we found that women exhibited greater zygomaticus major muscle activity in response to dynamic happiness stimuli than static stimuli. Our data support the hypothesis that people mimic positive emotions and confirm the importance of dynamic stimuli in some emotional processing.</p></div

Mean (± SE) EMG activity changes for orbicularis oculi during presentation conditions.

<p>Asterisks indicate significant differences from baseline EMG responses. *: <i>p</i> < 0.05, **: <i>p</i> < 0.01.</p

Mean (± SE) rating of emotional intensity of facial expressions for presentation conditions.

<p>Asterisks indicate significant differences from baseline EMG responses. *: <i>p</i> < 0.05, ***: <i>p</i> < 0.001. Asterisks with lines beneath indicate significant differences between conditions (simple effects): *: <i>p</i> < 0.05, **: <i>p</i> < 0.05, ***: <i>p</i> < 0.001.</p