Arrhythmic manifestation of non-compaction cardiomyopathy of both ventricles

This paper presents a case report of a patient diagnosed with a rare non-compaction cardiomyopathy of both ventricles. The diagnosis was based on echocardiography after excluding other possible causes of myocardial damage. The reason for the initiation of cardiological diagnostics was a history of syncope, the cause of which was finally considered to be paroxysmal ventricular tachycardia. In the secondary prevention of sudden cardiac death, the patient was implanted with a cardioverter-defibrillator. The thrombus found in the left ventricle was successfully treated with anticoagulants

Arytmiczna manifestacja kardiomiopatii z niescalenia obu komór

W pracy przedstawiono opis przypadku pacjenta, u którego rozpoznano rzadką kardiomiopatię z niescalenia mięśnia obu komór serca. Rozpoznania dokonano na podstawie echokardiografii, po wykluczeniu innych możliwych przyczyn uszkodzenia mięśnia sercowego. Powodem rozpoczęcia diagnostyki kardiologicznej był wywiad omdleń, za których przyczynę ostatecznie uznano napadowe częstoskurcze komorowe. W profilaktyce wtórnej nagłej śmierci sercowej implantowano choremu wszczepialny kardiowerter-defibrylator. Stwierdzoną w lewej komorze skrzeplinę skutecznie leczono lekami przeciwzakrzepowymi.W pracy przedstawiono opis przypadku pacjenta, u którego rozpoznano rzadką kardiomiopatię z niescalenia mięśnia obu komór serca. Rozpoznania dokonano na podstawie echokardiografii, po wykluczeniu innych możliwych przyczyn uszkodzenia mięśnia sercowego. Powodem rozpoczęcia diagnostyki kardiologicznej był wywiad omdleń, za których przyczynę ostatecznie uznano napadowe częstoskurcze komorowe. W profilaktyce wtórnej nagłej śmierci sercowej implantowano choremu wszczepialny kardiowerter-defibrylator. Stwierdzoną w lewej komorze skrzeplinę skutecznie leczono lekami przeciwzakrzepowymi

Neural activity and new methods of computational analysis in the model of mammalian brain cortex

Analysis of the real brain’s neural activity can be performed in many different ways like forexample electroencephalography. Sometimes the value of neural membrane potential is collectedeven from particular cells, using electrodes in neurophysiological experiments. However, thisinvasive method can be performed only on animals and in most cases leads to death of theexperiment’s subject. Computer modelling and simulation are often very important for the designof real experiments and in this paper we present the set of three new methods of neurodynamicalanalysis, two of them analogical to the probing used in neurophysiology andelectroencephalography. We show that in some cases our approach can be even more effectivethan the techniques used in bio-medical laboratories

The use of 90Y-PET imaging in evaluation of 90Y-microspheres distribution in the liver: initial results

BACKGROUND: Selective internal radiation therapy (SIRT) with 90Y-microspheres infusion into the hepatic artery is a novel method for palliative treatment of primary and metastatic liver cancer. The post-procedural 90Y dose estimation in the liver is very difficult because direct measurement of b particles is not possible with SPECT/CT. New methods are needed to assess the 90Y-microspheres liver distribution. In the present paper we evaluate the 90Y-PET for these purposes. MATERIALS AND METHODS: A GE Discovery ST PET/CT scanner with a copper ring protected the gantry was used for images acquisition. For SPECT/CT imaging, a GE Infinia VCHWK4 with HEPG collimators was used. The liver 90Y-microspheres (SIR-Spheres, SIRTEX, Australia) dose distribution after selective internal radiotherapy treatment was evaluated in three patients (9 lesions in total). The activity of 90Y-microspheres delivered into the liver ranged from 1.0 GBq to 2.2 GBq. The correlations between liver lesions detected with 90Y-PET, 99mTc-MAA and 90-bremsstrahlung were investigated and compared with CT images obtained before and after the procedure. RESULTS: The mean T/N ratio was 2.7 in 99mTc-MAA, 2.3 in 90Y-bremsstrahlung and 3.6 in 90Y-PET. The mean 90Y absorbed dose in tumor was 133 Gy, 112 Gy, and 187 Gy, respectively. The mean liver tissue radiation was 15.5 Gy. According to RECIST criteria, one PR (mCRC) and two SD were observed (mCRC and PC). Time to progression was 217 and 117 days in two patients with mCRC and 214 days in the patient with PC. CONCLUSIONS: 90Y-PET/CT images give crucial information regarding 90Y-microspheres distribution and dosimetry and may serve as a predictor of efficiency of radioembolisation

Glucagon-like peptide-1 receptor imaging with [Lys^{40}(Ahx-HYNIC-^{99m}Tc/EDDA)NH_2]-exendin-4 for the detection of insulinoma

PURPOSE: The objective of this article is to present a new method for the diagnosis of insulinoma with the use of [Lys(40)(Ahx-HYNIC-(99m)Tc/EDDA)NH(2)]-exendin-4. METHODS: Studies were performed in 11 patients with negative results of all available non-isotopic diagnostic methods (8 with symptoms of insulinoma, 2 with malignant insulinoma and 1 with nesidioblastosis). In all patients glucagon-like peptide-1 (GLP-1) receptor imaging (whole-body and single photon emission computed tomography/CT examinations) after the injection of 740 MBq of the tracer was performed. RESULTS: Both sensitivity and specificity of GLP-1 receptor imaging were assessed to be 100 % in patients with benign insulinoma. In all eight cases with suspicion of insulinoma a focal uptake in the pancreas was found. In six patients surgical excision of the tumour was performed (type G1 tumours were confirmed histopathologically). In one patient surgical treatment is planned. One patient was disqualified from surgery. In one case with malignant insulinoma pathological accumulation of the tracer was found only in the region of local recurrence. The GLP-1 study was negative in the other malignant insulinoma patient. In one case with suspicion of nesidioblastosis, a focal accumulation of the tracer was observed and histopathology revealed coexistence of insulinoma and nesidioblastosis. CONCLUSION: [Lys(40)(Ahx-HYNIC-(99m)Tc/EDDA)NH(2)]-exendin-4 seems to be a promising diagnostic tool in the localization of small insulinoma tumours, but requires verification in a larger series of patients

Zaopatrzenie krwotoku poporodowego szwami kompresyjnymi. Globalny wpływ na śmiertelność kobiet

Artykuł przedstawia siłę empirycznego podejścia dotyczącego postępowania w krwotoku poporodowym (PPH) z użyciem szwów kompresyjnych oraz podejmuje analizę piśmiennictwa postępowania w krwotoku poporodowym na świecie w ciągu ostatnich 20 lat. Szwy kompresyjne macicy według B-Lyncha są używane w ośrodkach na całym świecie i są najpopularniejszym i najbardziej skutecznym sposobem postępowania w PPH. Dostępne dane sugerują, że ponad 2 000 000 kobiet odniosło korzyści z zastosowania szwów B-Lyncha w ciągu 20 lat od ich wprowadzenia