Wykorzystanie techniki infuzji do budowy podobrazi pomocniczych na przykładzie obrazu Aleksandra Kobzdeja Hors cadre Nr 53

In the paper results of investigation of: technical structure, state of preservation, reasons of deterioration and the undertaken conservation restoration treatment of works of artist Alexander Kobzdej (1920-1972) will be presented. In the cycle Hors Cadre from 1971 Kobzdej redefined the function of the individual elements consisted in the traditional easel painting. As in his earlier work Wykorzystanie techniki infuzji do budowy podobrazi pomocniczych… 549 he incorporated the space into the construction of his paintings, yet in this case their technical structure is totally irrelevant to the traditional easel painting studio practice. The support is made of 3D shaped metal wire net, being core for the polyester-lignite laminate, made in a way enabling application of the water based medium paint layer on its top. For the reason of their structure, these – as it appeared very sensitive paintings – became a challenge for the conservator – restorer. Within the Ph.D. dissertation, M.A. thesis as well as through practical diploma works executed in our Department the research conducted on them let to propose guidelines of conservation care for these objects as well as conservation-restoration treatments. One of the main problem it appeared to be the unstable character of their supports, making safe storing, transport and exposition impossible. It was necessary to develop individually dedicated auxiliary supports for each work. Materials used were, among others: polycarbonates, aluminium wire nets, epoxy-polycarbonate laminates made by the infusion technique). The auxiliary supports made in different techniques let significantly slowing down the unwanted changes in the paintings structure, the methodology of the local repairs of the original support was developed, meaning filling in the losses of the polyester laminate and of extremely matt paint layer surface. Gained experience can be used during conservation of the other paintings of the cycle Hors Cadre (about seventy works), certain elements of former cycle (Clefts), and of other paintings in which analogical materials were used.

Symplectic charges in the Yang-Mills theory of the normal conformal Cartan connection: applications to gravity

It is known that a source-free Yang-Mills theory with the normal conformal Cartan connection used as the gauge potential gives rise to equations of motion equivalent to the vanishing of the Bach tensor. We investigate the conformally invariant presymplectic potential current obtained from this theory and find that on the solutions to the Einstein field equations, it can be decomposed into a topological term derived from the Euler density and a part proportional to the potential of the standard Einstein-Hilbert Lagrangian. The pullback of our potential to the asymptotic boundary of asymptotically de Sitter spacetimes turns out to coincide with the current obtained from the holographically renormalized gravitational action. This provides an alternative derivation of a symplectic structure on scri without resorting to holographic techniques. We also calculate our current at the null infinity of asymptotically flat spacetimes and in particular show that it vanishes for variations induced by the BMS symmetries. In addition, we calculate the Noether currents and charges corresponding to gauge transformations and diffeomorphisms.Comment: 29 pages, 0 figure

Cellular Classes in the Human Brain Revealed In Vivo by Heartbeat-Related Modulation of the Extracellular Action Potential Waveform

Determining cell types is critical for understanding neural circuits but remains elusive in the living human brain. Current approaches discriminate units into putative cell classes using features of the extracellular action potential (EAP); in absence of ground truth data, this remains a problematic procedure. We find that EAPs in deep structures of the brain exhibit robust and systematic variability during the cardiac cycle. These cardiac-related features refine neural classification. We use these features to link bio-realistic models generated from in vitro human whole-cell recordings of morphologically classified neurons to in vivo recordings. We differentiate aspiny inhibitory and spiny excitatory human hippocampal neurons and, in a second stage, demonstrate that cardiac-motion features reveal two types of spiny neurons with distinct intrinsic electrophysiological properties and phase-locking characteristics to endogenous oscillations. This multi-modal approach markedly improves cell classification in humans, offers interpretable cell classes, and is applicable to other brain areas and species

Combined Phase-Rate Coding by Persistently Active Neurons as a Mechanism for Maintaining Multiple Items in Working Memory in Humans

Maintaining multiple items in working memory (WM) is central to human behavior. Persistently active neurons are thought to be a mechanism to maintain WMs, but it remains unclear how such activity is coordinated when multiple items are kept in memory. We show that memoranda-selective persistently active neurons in the human medial temporal lobe phase lock to ongoing slow-frequency (1–7 Hz) oscillations during WM maintenance. The properties of phase locking are dependent on memory content and load. During high memory loads, the phase of the oscillatory activity to which neurons phase lock provides information about memory content not available in the firing rate of the neurons. We provide a computational model that reveals that inhibitory-feedback-mediated competition between multiple persistently active neurons reproduces this phenomenon. This work reveals a mechanism for the active maintenance of multiple items in WM that relies on persistently active neurons whose activation is orchestrated by oscillatory activity

Combined Phase-Rate Coding by Persistently Active Neurons as a Mechanism for Maintaining Multiple Items in Working Memory in Humans

Maintaining multiple items in working memory (WM) is central to human behavior. Persistently active neurons are thought to be a mechanism to maintain WMs, but it remains unclear how such activity is coordinated when multiple items are kept in memory. We show that memoranda-selective persistently active neurons in the human medial temporal lobe phase lock to ongoing slow-frequency (1–7 Hz) oscillations during WM maintenance. The properties of phase locking are dependent on memory content and load. During high memory loads, the phase of the oscillatory activity to which neurons phase lock provides information about memory content not available in the firing rate of the neurons. We provide a computational model that reveals that inhibitory-feedback-mediated competition between multiple persistently active neurons reproduces this phenomenon. This work reveals a mechanism for the active maintenance of multiple items in WM that relies on persistently active neurons whose activation is orchestrated by oscillatory activity

Epidemiology of urogenital injuries in the Regional Specialist Hospital in Puławy in years 2007 -2018

Introduction Trauma is defined as damage to cells, tissues and organs caused by external factors acting on them. According to WHO data, trauma caused 4.8 millions of deaths in 2016. Urogenital trauma occurs in 10% of all the injuries in the human population. Aim of the study The aim of this study was to characterize the patients treated for injuries in Urology Department in Regional Hospital in Poland and compare the results with the data from literature. Material and methods The study involved patients hospitalized in Regional Specialist Hospital in Puławy, Poland from 2007 to 2018. The survey was based at analysis of medical documentation. The collected data has been subjected to statistical analysis. 66 patients were included in the study group. Their average age was 43.25 years. Results The absolute majority of patients were men – 81.81% (n=54), women – 18.18% (n=12). The average age for males was 42.27 and for the females – 44.25. Most frequent trauma in our study was the renal trauma 36.36% (n=24). 47.06% of this injuries were associated with MVA's. The second most frequent group was a genital trauma - 21 patients (31,81%). 81.81 % of them required surgical treatment. Another group constituted 10.6 % (n=7) were the patients treated for bladder injury. Penis was injured in 6.06% (n=4), 75% of patients required a surgery. Urether has been injured only in 4.55%. Conclusions Kidney is the most frequent organ of genitourinary tract, affected by trauma, particularly during MVA's. Victims are usually treated conservatively. External genitalia injuries, especially male, are also very frequent. Mostly patients need a rapid surgical intervention but appropriate treatment allows the patient to recover completely without any lasting disabilit

Przewlekłe zakrzepowo-zatorowe nadciśnienie płucne — diagnostyka i nowe możliwości terapii farmakologicznej w świetle wytycznych ESC/ERS 2015

Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious disease, usually caused by an incomplete recanalization of pulmonary vessels after acute pulmonary embolism. This leads to a significant remodeling of the remaining pulmonary vasculature and right ventricular failure. The prognosis depends on early diagnosis and proper treatment. Despite the availability of an effective method — pulmonary endarterectomy (PEA), more than one-third of patients is not eligible for this type of operation due to the localization and the character of lesions. In these patients, as well as in the persistent CTEPH after PEA, specific therapy with riociguat is recommended. Balloon pulmonary angioplasty, a new treatment method, can be considered in certain patients with inoperable CTEPH.Przewlekłe zakrzepowo-zatorowe nadciśnienie płucne (CTEPH) to poważne schorzenie, najczęściej wywołane niepełną rekanalizacją naczyń płucnych po przebytej ostrej zatorowości płucnej prowadzącą do znacznej przebudowy pozostałego łożyska płucnego i w efekcie — do niewydolności prawokomorowej serca. Rokowanie zależy od szybkiego rozpoznania CTEPH i odpowiedniego leczenia. Mimo dostępności skutecznej metody, tj. endarterektomii płucnej (PEA), ponad 1/3 chorych nie kwalifikuje się do tego typu operacji ze względu na lokalizację i charakter zmian. W ich przypadku, oraz przy przetrwałym CTEPH po PEA, należałoby zastosować leczenie swoiste riociguatem. U pewnej grupy pacjentów można rozważyć nowoczesną metodę balonowej angioplastyki tętnic płucnych

Lithium in coalesced non-compact stars

Context. Galactic red novae are thought to be produced in stellar mergers between non-compact stars, such as main-sequence stars and cool giants. They are hoped to help in explaining physical processes involved in common envelope evolution and stellar binary collisions. Aims. We investigate the presence of lithium in three best-observed Galactic red nova remnants. Explaining the origin of lithium may point to mixing mechanism present before, during, or after the merger. Methods. The lithium line at 6707.81 A was compared to a feature of [Ca I at 6572.78 A to derive relative abundances in circumstellar gas. Absolute abundances were next calculated assuming the Solar calcium to lithium abundance ratio. Results. Lithium abundances were measured in the merger remnants of V838 Mon with A(Li)=2.3, CK Vul with A(Li)=2.5, and V1309 Sco with A(Li)=1.8. Conclusions. Lithium is overabundant in red novae, suggesting that at least some merger products activate the Cameron-Fowler mechanism whereby convective mixing can reach the deep stellar interior. Whether deep convection and associated diffusion alone or some other processes (e.g. spin down) can be responsible for driving the Cameron-Fowler mechanism in the remnants requires further studies. Early observations of lithium in V838 Mon hint that these mechanisms can activate early, perhaps already in the common envelope phase. These observations should be taken into account in modelling these complex systems.Comment: submitted to A&A; comments welcom

Impact of mild anaemia on dyspnoea during exertion and exercise tolerance in patients with acute exacerbation of chronic obstructive pulmonary disease

WSTĘP: Duszność i zmniejszenie tolerancji wysiłku są objawami zaostrzenia przewlekłej obturacyjnej choroby płuc (POChP). Niedokrwistość stanowi czynnik ryzyka obniżonej tolerancji wysiłku i duszności w stabilnej POChP. Mało jest danych na temat wpływu niedokrwistości na tolerancję wysiłku i duszność u chorych z zaostrzeniem POChP. Celem pracy była ocena wpływu obniżonego stężenia hemoglobiny we krwi na wyniki 6-minutowego testu chodu (6MWT) u pacjentów w trakcie zaostrzenia POChP.MATERIAŁ I METODY: Retrospektywna analiza danych zebranych w trakcie badania u chorych z zaostrzeniem POChP. Do oceny wykorzystano pierwsze dostępne oznaczenia stężenia hemoglobiny, wykonane w trakcie hospitalizacji. 6MWT wykonano po uzyskaniu poprawy klinicznej pacjenta. Nasilenie duszności oceniano przed oraz po 6MWT. W trakcie 6MWT mierzono saturację krwi tlenem (SpO2).WYNIKI: Zbadano 402 pacjentów z zaostrzeniem POChP (średnie stadium wg PTChP 3,5 ± 0,6). Chorzy z niedokrwistością (26% zbadanych, wiek średni 74,5 ± 8,2 roku) w teście chodu pokonali 258,1 ± 125,1 m, z desaturacją wysiłkową na poziomie 2,9 ± 2,6%. Chorzy bez niedokrwistości (74% zbadanych, wiek średni 70,2 ± 8,7 roku) w teście chodu pokonali 271 ± 136 m, z desaturacją wysiłkową na poziomie 3,8 ± 3,7%. Stężenie hemoglobiny nie korelowało z 6MWT, dusznością po 6MWT, saturacją w trakcie wysiłku i desaturacją krwi po wysiłku.WNIOSKI: Łagodnie obniżone stężenie hemoglobiny we krwi nie wpływało na wyniki 6MWT u pacjentów z zaostrzeniem POChP.  INTRODUCTION: Dyspnoea and decreased exercise tolerance are symptoms of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Anaemia is a risk factor for reduced functional capacity and dyspnoea in stable COPD. There is limited information about the impact of anaemia on functional capacity and dyspnoea of patients during AECOPD. The aim of this study was to evaluate the impact of decreased blood haemoglobin concentration on the results of six-minute walking test (6MWT) in patients during AECOPD.MATERIAL AND METHODS: A post hoc analysis of data collected from prospective long-term studies on AECOPD. Haemoglobin concentration from the first obtainable hospital measurement were included in the assessment. 6MWT was performed after clinical improvement of the patient. Dyspnoea at baseline and after exercise and oxygen saturation (SpO2) during exercise was measured.RESULTS: (presented as means ± SD): 402 patients with exacerbation of COPD (COPD stage 3.5 ± 0.6) were examined. Patients with anaemia (26% of those studied, age 74.5 ± 8.2 years) achieved 258.1 ± 125.1 m during 6MWT, with exertional desaturation of 2.9 ± 2.6%. Patients without anaemia (74% of those studied, age 70.2 ± 8.7 years) achieved 271 ± 136.0 m during 6MWT with exertional desaturation of 3.8 ± 3.7%. The haemoglobin concentration did not correlate with 6MWT, dyspnoea during 6MWT, or exercise oxygenation and blood desaturation during exercise.CONCLUSION: Mildly decreased blood haemoglobin concentration did not influence the results of 6MWT in patients with AECOPD.