On the Design and Exploitation of User's Personal and Public Information for Semantic Personal Digital Photograph Annotation

Automating the process of semantic annotation of digital personal photographs is a crucial step towards efficient and effective management of this increasingly high volume of content. However, this is still a highly challenging task for the research community. This paper proposes a novel solution. Our solution integrates all contextual information available to and from the users, such as their daily emails, schedules, chat archives, web browsing histories, documents, online news, Wikipedia data, and so forth. We then analyze this information and extract important semantic terms, using them as semantic keyword suggestions for their photos. Those keywords are in the form of named entities, such as names of people, organizations, locations, and date/time as well as high frequency terms. Experiments conducted with 10 subjects and a total of 313 photos proved that our proposed approach can significantly help users with the annotation process. We achieved a 33% gain in annotation time as compared to manual annotation. We also obtained very positive results in the accuracy rate of our suggested keywords

Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing

The use of primary patient-derived organoids for drug sensitivity and resistance testing could play an important role in precision cancer medicine. We developed expandable ovarian cancer organoids in<3 weeks; these organoids captured the characteristics of histological cancer subtypes and replicated the mutational landscape of the primary tumours. Seven pairs of organoids (3 high-grade serous, 1 clear cell, 3 endometrioid) and original tumours shared 59.5% (36.1-73.1%) of the variants identified. Copy number variations were also similar among organoids and primary tumours. The organoid that harboured the BRCA1 pathogenic variant (p.L63*) showed a higher sensitivity to PARP inhibitor, olaparib, as well as to platinum drugs compared to the other organoids, whereas an organoid derived from clear cell ovarian cancer was resistant to conventional drugs for ovarian cancer, namely platinum drugs, paclitaxel, and olaparib. The overall success rate of primary organoid culture, including those of various histological subtypes, was 80% (28/35). Our data show that patient-derived organoids are suitable physiological ex vivo cancer models that can be used to screen effective personalised ovarian cancer drugs

Efficient producer mobility support in named data networking

Named Data Networking (NDN) is a promising architecture for the future Internet and it is mainly designed for efficient content delivery and retrieval. However, producer mobility support is one of the challenging problems of NDN. This paper proposes a scheme which aims to optimize the tunneling-based producer mobility solution in NDN. It does not require NDN routers to change their routing tables (Forwarding Information Base) after a producer moves. Instead, the Interest packet can be sent from a consumer to the moved producer using the tunnel. The piggybacked Data packet which is sent back to the consumer will trigger the consumer to send the following Interest packets through the optimized path to the producer. Moreover, a naming scheme is proposed so that the NDN caching function can be fully utilized. An analysis is carried out to evaluate the performance of the proposal. The results indicate that the proposed scheme reduces the network cost compared to related works and supports route optimization for enhanced producer mobility support in NDN

Germline multigene panel testing revealed a BRCA2 pathogenic variant in a patient with suspected Lynch syndrome

There has been a rapid advance in germline multigene panel testing by next-generation sequencing, and it is being widely used in clinical settings. A 56-year-old woman suspected of having Lynch syndrome was identified as a BRCA2 pathogenic variant carrier by multigene panel testing. The patient was diagnosed with endometrial cancer at the age of 39 years, and total laparoscopic hysterectomy and bilateral salpingectomy were performed at the age of 49 years; however, bilateral oophorectomy was not performed at that time. As she had a family history of colorectal cancer and a history of endometrial cancer, Lynch syndrome was suspected. However, germline multigene panel testing revealed a pathogenic BRCA2 variant rather than pathogenic variants in mismatch repair genes. In this case, with conventional genetic risk assessment, we were unable to determine whether the patient had a high risk of hereditary breast and ovarian cancer; thus, germline multigene panel testing may provide valuable information to improve disease management strategies for patients in clinical settings. Particularly, germline multigene panel testing may be useful for detecting hereditary tumor syndromes if a patient does not present with a typical family history of cancer