A patch-clamp study of native and recombinant glutamate receptors

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A solution to energy and environmental problems of electric power system using hybrid harmony search-random search optimization algorithm

In recent years, global warming and carbon dioxide (CO2) emission reduction have become important issues in India, as CO2 emission levels are continuing to rise in accordance with the increased volume of Indian national energy consumption under the pressure of global warming, it is crucial for Indian government to impose the effective policy to promote CO2 emission reduction. Challenge of supplying the nation with high-quality and reliable electrical energy at a reasonable cost, converted government policy into deregulation and restructuring environment. This research paper presents aims to presents an effective solution for energy and environmental problems of electric power using an efficient and powerful hybrid optimization algorithm: Hybrid Harmony search-random search algorithm. The proposed algorithm is tested for standard IEEE-14 bus, -30 bus and -56 bus system. The effectiveness of proposed hybrid algorithm is compared with other well-known evolutionary, heuristics and meta-heuristics search algorithms. For multi-objective unit commitment, it is found that as there are conflicting relationship between cost and emission, if the performance in cost criterion is improved, performance in the emission is seen to deteriorate

Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories

Maladaptive reward memories (MRMs) are involved in the development and maintenance of acquired overconsumption disorders, such as harmful alcohol and drug use. The process of memory reconsolidation - where stored memories become briefly labile upon retrieval - may offer a means to disrupt MRMs and prevent relapse. However, reliable means for pharmacologically weakening MRMs in humans remain elusive. Here we demonstrate that the N-methyl D-aspartate (NMDA) antagonist ketamine is able to disrupt MRMs in hazardous drinkers when administered immediately after their retrieval. MRM retrieval + ketamine (RET + KET) effectively reduced the reinforcing effects of alcohol and long-term drinking levels, compared to ketamine or retrieval alone. Blood concentrations of ketamine and its metabolites during the critical ‘reconsolidation window’ predicted beneficial changes only following MRM reactivation. Pharmacological reconsolidation interference may provide a means to rapidly rewrite maladaptive memory and should be further pursued in alcohol and drug use disorders

Metformin modulates microbiota and improves blood pressure and cardiac remodeling in a rat model of hypertension

AIMS: Metformin has been attributed to cardiovascular protection even in the absence of diabetes. Recent observations suggest that metformin influences the gut microbiome. We aimed to investigate the influence of metformin on the gut microbiota and hypertensive target organ damage in hypertensive rats. METHODS: Male double transgenic rats overexpressing the human renin and angiotensinogen genes (dTGR), a model of angiotensin II-dependent hypertension, were treated with metformin (300 mg/kg/day) or vehicle from 4 to 7 weeks of age. We assessed gut microbiome composition and function using shotgun metagenomic sequencing and measured blood pressure via radiotelemetry. Cardiac and renal organ damage and inflammation were evaluated by echocardiography, histology, and flow cytometry. RESULTS: Metformin treatment increased the production of short-chain fatty acids (SCFA) acetate and propionate in feces without altering microbial composition and diversity. It significantly reduced systolic and diastolic blood pressure and improved cardiac function, as measured by end-diastolic volume, E/A, and stroke volume despite increased cardiac hypertrophy. Metformin reduced cardiac inflammation by lowering macrophage infiltration and shifting macrophage subpopulations towards a less inflammatory phenotype. The observed improvements in blood pressure, cardiac function, and inflammation correlated with fecal SCFA levels in dTGR. In vitro, acetate and propionate altered M1-like gene expression in macrophages, reinforcing anti-inflammatory effects. Metformin did not affect hypertensive renal damage or microvascular structure. CONCLUSION: Metformin modulated the gut microbiome, increased SCFA production, and ameliorated blood pressure and cardiac remodeling in dTGR. Our findings confirm the protective effects of metformin in the absence of diabetes, highlighting SCFA as a potential mediators