Incidence of dermatological disorders among paediatric population in skin outpatient department at Government Rajaji Hospital, Madurai

The present study was done to assess the Incidence of dermatological disorders among Paediatric population in Skin Outpatient Department at Government Rajaji Hospital, Madurai. OBJECTIVES: 1. To assess the incidence of dermatological disorders among male and female Paediatric population in skin outpatient department. 2. To associate the dermatological disorders among male and female Paediatric population in skin outpatient department. HYPOTHESES: There is a significant difference in the incidence of dermatological disorders among male and female Paediatric population. There is a significant association between the male and female Paediatric population in Skin Outpatient Department with their selected socio demographic variables. METHODOLOGY: Non experimental descriptive research design was used to select 150 subjects by Non-probability (Consecutive) sampling. RESULTS: This study revealed that majority of the Paediatric population, in male 82 (54.7%) in female 68 (45.33%) were had dermatological disorders. CONCLUSION: The study findings evidence that among Paediatric population male were had more dermatological disorders than the female Paediatric population

Molecular and biochemical characterization of a new thermostable bacterial laccase from<i> Meiothermus ruber</i> DSM 1279

A new bacterial laccase gene (mrlac) fromMeiothermus ruberDSM 1279 was successfully overexpressed to produce a laccase (Mrlac) in soluble form inEscherichia coliduring simultaneous overexpression of a chaperone protein (GroEL/ES).</p

Role of biology in the air-sea carbon flux in the Bay of Bengal and Arabian Sea

A physical-biological-chemical model (PBCM) is used for investigating the seasonal cycle of air-sea carbon flux and for assessing the effect of the biological processes on seasonal time scale in the Arabian Sea (AS) and Bay of Bengal (BoB), where the surface waters are subjected to contrasting physical conditions. The formulation of PBCM is given in Swathi et al (2000), and evaluation of several ammonium-inhibited nitrate uptake models is given in Sharada et al (2005). The PBCM is here first evaluated against JGOFS data on surface pCO2 in AS, Bay of Bengal Process Studies (BoBPS) data on column integrated primary productivity in BoB, and WOCE Il data on dissolved inorganic carbon (DIC) and alkalinity (ALK) in the upper 500 meters at 9°N in AS and at 10°N in BoB in September-October. There is good qualitative agreement with local quantitative discrepancies. The net effect of biological processes on air-sea carbon flux on seasonal time scale is determined with an auxiliary computational experiment, called the abiotic run, in which the biological processes are turned off. The difference between the biotic run and abiotic run is interpreted as the net effect of biological processes on the seasonal variability of chemical variables. The net biological effect on air-sea carbon flux is found to be highest in southwest monsoon season in the northwest AS, where strong upwelling drives intense new production. The biological effect is larger in AS than in BoB, as seasonal upwelling and mixing are strong in AS, especially in the northeast, while coastal upwelling and mixing are weak in BoB

Double blind randomized comparative study of transdermal fentanyl patch for post operative pain relief in major abdominal surgery as a component of multimodal analgesic therapy

Background: There are various methods of alleviating post-operative pain, multimodal analgesia is the recommended practice. Fentanyl patch can also be used in the management of acute postoperative pain. We have done a study to compare the efficacy of fentanyl patch to a placebo patch as a part of multimodal analgesic strategy.Methods: Forty four patients were randomized into two groups. Groups were named as FP (Fentanyl patch) and P (Placebo). The Patch was placed 10-12 hours before surgery and patient was monitored for 72 hours postoperatively for pain by NRS (Numeric Rating Scale). All the patients received regular Paracetamol and Diclofenac Sodium. Tramadol was given as rescue analgesia if the NRS scale was more than 5. Data was analysed using Windows stat version 9.2 from Indostat services.Results: There was statistically significant difference in the consumption of Tramadol in patients with FP group (19.44 mg) as compared to P group (72.22mg) over 72 hours. The Numerical Rating scale was also much lower in the FP group at 8, 16, 24, 32, 40, 48, 56, 64 and 72 hours. Maximum difference in the pain score being at 24 hours for the FP group. No difference in the Sedation, Pruritus, Respiratory depression, Nausea and vomiting scores in the two groups.Conclusions: Transdermal Fentanyl Patch of 25 µg/hr when applied 10-12 hours before surgery provides effective postoperative pain relief after major abdominal surgery as a part of multimodal analgesia

Seroprevalence of hepatitis B virus and hepatitis C virus co-infection in human immunodeficiency virus infected patients at a tertiary care hospital in South India

Background: About one third of human immunodeficiency virus (HIV) infected patients are co infected with either hepatitis B virus (HBV) or hepatitis C virus (HCV) as the three viruses have similar routes of transmission that is through transfusion of blood and blood products, sharing of needles to inject drugs and unprotected sexual activity. The survival of HIV infected patients has been markedly improved with highly active antiretroviral therapy (HAART). However several studies showed that the liver diseases caused by HBV or HCV have emerged as one of the leading causes of non AIDS related deaths in HIV patients. The objective of this work was to study the prevalence of HBV & HCV co-infection in HIV infected patients at a Tertiary care centre in South India.Methods: The study group includes 100 HIV seropositive individuals confirmed by three rapid tests as per NACO (National AIDS Control Organization) guidelines in ICTC (Integrated Counseling and Testing Centre), Department of Microbiology, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India. Age and sex matched 100 HIV seronegative individuals were also included in the study as controls. Both the groups were screened for detection of HBV and HCV markers by one rapid test and a solid phase enzyme linked immunosorbent assay (sandwich ELISA).Results: Out of 100 HIV positive patients in the study group 12(12%) were co infected with HBV and 2(2%) were co infected with HCV. Out of 12 HIV and HBV co infected patients 7(58.3%) were females and 5(41.7%) were males. The HIV &HCV co infected patients were both females. Co infection of HBV & HCV with HIV was found to be 0(0%). Co infection was most commonly seen in the age group 31-40 years followed by 21 – 39 years. In the control group out of 100 HIV negative individuals, 1(1%) was infected with HBV infection.Conclusions: The routine screening of HBV and HCV should be mandatory for HIV infected patients, as there is more chance of co infection with these Hepatitis viruses due to enhanced immunodeficiency by HIV and similar routes of transmission. Clear National policies should be established which should include clear economic and health care strategies to improve quality of living conditions, education and easy access to health care facilities.

Seroprevalence of syphilis in human immunodeficiency virus patients

Background: Syphilis is a sexually transmitted infection caused by, Treponema pallidum. Syphilis facilitates the transmission and acquisition of human immunodeficiency virus (HIV) and causes transient increase in the viral load. Sexually transmitted infections (STI) are 3-5 times more likely to acquire HIV infection, if exposed to the virus through sexual contact. Aim of the study was to estimate the seroprevalence of Syphilis in HIV patients.Methods: A total of 920 blood samples were collected from HIV patients attending ART (Antiretroviral therapy) centre and were tested for Syphilis by using Rapid Plasma Reagin (RPR) and Treponema pallidum Hemagglutination Assay (TPHA). A total of 100 HIV non-reactive individuals were taken as a control group.Results: Out of 920 samples, 102 (11.1%) were positive for Syphilis. Out of 102 Syphilis seropositive patients, males (76.5%) were more commonly affected in age group of 21-40 years. Both RPR and TPHA were reactive in 46% of cases and only TPHA reactive in 53.9% of cases. Out of 100 HIV non-reactive patients, 5% of patients are reactive for Syphilis.Conclusions: In the present study, prevalence of Syphilis was more in HIV patients compared to HIV non-reactive persons. Persons with HIV infection acquired through sexual route should be screened for Syphilis by one nonspecific test along with specific test to confirm the diagnosis. This will help in proper management of the patients having Syphilis and HIV co-infection

A power law solution for FRLW Universe with observational constraints

This paper examines a power law solution under $f(R,T)$ gravity for an isotropic and homogeneous universe by considering its functional form as $f(R,T) = R + \xi RT$, where $\xi$ is a positive constant. In $f(R,T)$ gravity, we have built the field equation for homogeneous and isotropic spacetime. The developed model's solution is $a = \alpha t^{\beta}$. We have used the redshift in the range $0 \leq z \leq 1.965$ and obtained the model parameters $\alpha$, $\beta$, $H_0$ by using the Markov Chain Monte Carlo (MCMC) method. The constrained values of the model parameter are as follows: $H_0 = 67.098^{+2.148}_{-1.792}$ km s$^{-1}$ Mpc$^{-1}$, $H_0 = 67.588^{+2.229}_{-2.170}$ km s$^{-1}$ Mpc$^{-1}$, $H_0 = 66.270^{+2.215}_{-2.181}$ km s$^{-1}$ Mpc$^{-1}$, $H_0 = 65.960^{+2.380}_{-1.834}$ km s$^{-1}$ Mpc$^{-1}$, $H_0 = 66.274^{+2.015}_{-1.864}$ km s$^{-1}$ Mpc$^{-1}$ which have been achieved by bounding the model with the Hubble parameter ($H(z)$) dataset, Baryon Acoustic Oscillations (BAO) dataset, Pantheon dataset, joint $H(z)$ + Pantheon dataset and collective $H(z)$ + BAO + Pantheon dataset, respectively. These computed $H_o$ observational values agree well with the outcomes from the Plank collaboration group. Through an analysis of the energy conditions' behaviour on our obtained solution, the model has been examined and analysed. Using the Om diagnostic as the state finder diagnostic tool and the jerk parameter, we have also investigated the model's validity. Our results show that, within a certain range of restrictions, the proposed model agrees with the observed signatures