Diastereoselective Hydroxymethylation of Cyclic N-tert-Butanesulfinylketimines Using Methoxymethanol as Formaldehyde Source

A stable and easy-to-handle source of anhydrous monomeric formaldehyde is used

Diastereoselective Hydroxymethylation of Cyclic <i>N</i>-<i>tert</i>-Butanesulfinylketimines Using Methoxymethanol as Formaldehyde Source

Hydroxymethylation of cyclic <i>tert</i>-butanesulfinylketimine-derived lithium enamides with methoxymethanol proceeds with excellent diastereoselectivity (99:1 dr). Methoxymethanol is a stable and easy-to-handle source of anhydrous monomeric formaldehyde in the reaction with lithium enamides. Cyclic α-hydroxymethyl ketimines undergo highly diastereoselective reduction to <i>syn</i>- or <i>anti</i>-1,3-amino alcohols

Diastereoselective Hydroxymethylation of Cyclic <i>N</i>-<i>tert</i>-Butanesulfinylketimines Using Methoxymethanol as Formaldehyde Source

Hydroxymethylation of cyclic <i>tert</i>-butanesulfinylketimine-derived lithium enamides with methoxymethanol proceeds with excellent diastereoselectivity (99:1 dr). Methoxymethanol is a stable and easy-to-handle source of anhydrous monomeric formaldehyde in the reaction with lithium enamides. Cyclic α-hydroxymethyl ketimines undergo highly diastereoselective reduction to <i>syn</i>- or <i>anti</i>-1,3-amino alcohols

Stereoselective Synthesis of the Diazonamide A Macrocyclic Core

Stereoselective synthesis of the right-hand heteroaromatic macrocycle of diazonamide A features C16–C18 bond formation in the Suzuki–Miyaura cross-coupling and atropodiastereoselective Dieckmann-type macrocyclization as key steps. The Suzuki–Miyaura cross-coupling gave the best yields when it was catalyzed by a palladium–dioxygen complex