Composition Portfolio, Maria Kallionpää

Supporting composition portfolio to DPhil thesis: Beyond the piano: the super instrument. Widening the instrumental capacities in the context of the piano music of the 21st century. Individual scores give instruction to performing the work. Maria Kallionpää, Dphil in Music (Composition), Faculty of Music, University of Oxford. TT 2014 Table of Contents Composition Portfolio Orchestral and Choral Works El Canto de la Guerra/The Song of War Kuru Seamar Chamber Music Works Toccata Solo Works Fantasia Raindrops El Safari de la Muerte/Le Safari de la Mort Sonnenschände – Sonnenwende CD Celestifilia, acoustic version Celestifilia, principal version, digital realisation El Canto de la Guerra/The Song of War Kuru La Safari de la Muerte/Le Safari de la Mort DVD Sonnenschände – Sonnenwende, video file Toccata, video file</ul

Composition Portfolio, Maria Kallionpää

Supporting composition portfolio to DPhil thesis: Beyond the piano: the super instrument. Widening the instrumental capacities in the context of the piano music of the 21st century. Individual scores give instruction to performing the work

Beyond the piano: the super instrument. Widening the instrumental capacities in the context of the piano music of the 21st century

Thanks to the development of new technology, musical instruments are no more tied to their existing acoustic or technical limitations as almost all parameters can be augmented or modified in real time. An increasing number of composers, performers, and computer programmers have thus become interested in different ways of "supersizing" acoustic instruments in order to open up previously-unheard instrumental sounds. This leads us to the question of what constitutes a super instrument and what challenges does it pose aesthetically and technically? This work explores the effects that super instruments have on the identity of a given solo instrument, on the identity of a composition and on the experience of performing this kind of repertoire. The super instrument comes to be defined as a bundle of more than one instrumental lines that achieve a coherent overall identity when generated in real time. On the basis of my own personal experience of performing the works discussed in this dissertation, super instruments vary a great deal but each has a transformative effect on the identity and performance practice of the pianist. This discussion approaches the topic from the viewpoint of contemporary keyboard music, showcasing examples of super instrument compositions of the 21st century. Thus, the main purposes of this practise based research project is to explore the essence and role of piano or toy piano in a super instrument constellation, as well as the performer's role as a "super instrumentalist". I consider these issues in relation to case studies drawn from my own compositional work and a selection of works composed by Karlheinz Essl and Jeff Brown. Appendix: Contents of CD and DVD CD Track 1: Maria Kallionpää: Zusammenbindenbinden.Winden? –Hommage a Schumann. Tuuli Lempa, piano; Marko Myöhänen, electronics. Helsinki 2012. Track 2: Maria Kallionpää: Trinity Mania. Maria Kallionpää, piano; Florian Hartlieb, electronics. Vienna 2010. DVD Track 1: Karlheinz Essl: Sequitur V. Maria Kallionpää, toy piano; Karlheinz Essl, electronics</p

Beyond the piano: the super instrument. Widening the instrumental capacities in the context of the piano music of the 21st century

Thanks to the development of new technology, musical instruments are no more tied to their existing acoustic or technical limitations as almost all parameters can be augmented or modified in real time. An increasing number of composers, performers, and computer programmers have thus become interested in different ways of "supersizing" acoustic instruments in order to open up previously-unheard instrumental sounds. This leads us to the question of what constitutes a super instrument and what challenges does it pose aesthetically and technically? This work explores the effects that super instruments have on the identity of a given solo instrument, on the identity of a composition and on the experience of performing this kind of repertoire. The super instrument comes to be defined as a bundle of more than one instrumental lines that achieve a coherent overall identity when generated in real time. On the basis of my own personal experience of performing the works discussed in this dissertation, super instruments vary a great deal but each has a transformative effect on the identity and performance practice of the pianist. This discussion approaches the topic from the viewpoint of contemporary keyboard music, showcasing examples of super instrument compositions of the 21st century. Thus, the main purposes of this practise based research project is to explore the essence and role of piano or toy piano in a super instrument constellation, as well as the performer's role as a "super instrumentalist". I consider these issues in relation to case studies drawn from my own compositional work and a selection of works composed by Karlheinz Essl and Jeff Brown.This thesis is not currently available in OR

Germline and Somatic NF1 Alterations Are Linked to Increased HER2 Expression in Breast Cancer

NF1 germline mutation predisposes to breast cancer. NF1 mutations have also been proposed as oncogenic drivers in sporadic breast cancers. To understand the genomic and histologic characteristics of these breast cancers, we analyzed the tumors with NF1 germline mutations and also examined the genomic and proteomic profiles of unselected tumors. Among 14 breast cancer specimens from 13 women affected with neurofibromatosis type 1 (NF1), 9 samples (NF + BrCa) underwent genomic copy number (CN) and targeted sequencing analysis. Mutations of NF1 were identified in two samples and TP53 were in three. No mutation was detected in ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, PALB2, PTEN, RAD50, and STK11 HER2 (ErbB2) overexpression was detected by IHC in 69.2% (9/13) of the tumors. CN gain/amplification of ERBB2 was detected in 4 of 9 with DNA analysis. By evaluating HER2 expression and NF1 alterations in unselected invasive breast cancers in TCGA datasets, we discovered that among samples with ERBB2 CN gain/amplification, the HER2 mRNA and protein expression were much more pronounced in NF1-mutated/deleted samples in comparison with NF1-unaltered samples. This finding suggests a synergistic interplay between these two genes, potentially driving the development of breast cancer harboring NF1 mutation and ERBB2 CN gain/amplification. NF1 gene loss of heterozygosity was observed in 4 of 9 NF + BrCa samples. CDK4 appeared to have more CN gain in NF + BrCa and exhibited increased mRNA expression in TCGA NF1--altered samples. Cancer Prev Res; 11(10); 655-64. ©2018 AACR.status: publishe