INSTITUTIONAL ASPECTS OF THE CLUSTER DEVELOPMENT OF THE REGIONAL ECONOMIC SYSTEM

Purpose: The heterogeneity of the economic space has intensified in recent years in the process of transition and laying the foundations of a market economy in the CIS countries, as well as in the EU regions, due to its expansion. This unevenness was manifested as a result of different starting levels of economies, different resource endowments, the choice of their targets and priorities for socio-economic development, and the increased authority of local authorities. Methodology: This is analytical-logical research that has been done through content analysis and documentary and library research. Result: Problems of market fiasco in the regions, as well as the important role of local institutions in regional development are also noted in the EU and serve as a strong argument for the need for government intervention in regional policy, primarily from the standpoint of regulating the innovation sphere, financial assistance to create jobs or clusters capable of self-development. Applications: This research can be used for universities, teachers, and students. Novelty/Originality: In this research, the model of Institutional aspects of the cluster development of the regional economic system is presented in a comprehensive and complete manner

Phenomenological analysis of suicidal behavior in patients with cognitive impairment in recurrent depressive disorder

The aim of the study was to determine the characteristics of suicidal behaviour (SB) in patients with cognitive impairment in recurrent depressive disorder (RDD). Materials and methods: The article presents a phenomenological analysis of suicidal behavior in 123 patients with recurrent depressive disorder. The study of cognitive dysfunctions in patients with recurrent depressive disorder included an analysis of the severity of cognitive impairment and the characteristics of cognitive processes, executive functions, and the specifics of social functioning. The study of the features of suicidal behavior included an analysis of the severity of suicidal risk, diagnosis of symptoms, stress level, suicidal behavior in the past, communication capabilities, reactions of significant others, and the severity of autoaggressive predictors. A complex of research methods was used: clinical-psychopathological, psychometrical, psychodiagnostical and statistical. Results: It was determined that patients with recurrent depressive disorder have specific characteristics of suicidal behavior, which included: a moderate to low level of suicidal risk; the severity of symptoms of depression, tension, anxiety, guilt, hopelessness and exhaustion; repeated visits to doctors for help; presence and recurrence of stress factors; anamnestic burden; violation of communications; the presence of autoaggressive predictors. Conclusions: It was found that a weak level of cognitive deficit, a tendency to catastrophisation and self-blame, low switchability and increased focus on negative stimuli in patients with recurrent depressive disorder was associated with a high risk of their suicidal behavior

Institutional aspects of the cluster development of the regional economic system

© Beilin et al. Purpose: The heterogeneity of the economic space has intensified in recent years in the process of transition and laying the foundations of a market economy in the CIS countries, as well as in the EU regions, due to its expansion. This unevenness was manifested as a result of different starting levels of economies, different resource endowments, the choice of their targets and priorities for socio-economic development, and the increased authority of local authorities. Methodology: This is analytical-logical research that has been done through content analysis and documentary and library research. Result: Problems of market fiasco in the regions, as well as the important role of local institutions in regional development are also noted in the EU and serve as a strong argument for the need for government intervention in regional policy, primarily from the standpoint of regulating the innovation sphere, financial assistance to create jobs or clusters capable of self-development. Applications: This research can be used for universities, teachers, and students. Novelty/Originality: In this research, the model of Institutional aspects of the cluster development of the regional economic system is presented in a comprehensive and complete manner

Institutional aspects of the cluster development of the regional economic system

© Beilin et al. Purpose: The heterogeneity of the economic space has intensified in recent years in the process of transition and laying the foundations of a market economy in the CIS countries, as well as in the EU regions, due to its expansion. This unevenness was manifested as a result of different starting levels of economies, different resource endowments, the choice of their targets and priorities for socio-economic development, and the increased authority of local authorities. Methodology: This is analytical-logical research that has been done through content analysis and documentary and library research. Result: Problems of market fiasco in the regions, as well as the important role of local institutions in regional development are also noted in the EU and serve as a strong argument for the need for government intervention in regional policy, primarily from the standpoint of regulating the innovation sphere, financial assistance to create jobs or clusters capable of self-development. Applications: This research can be used for universities, teachers, and students. Novelty/Originality: In this research, the model of Institutional aspects of the cluster development of the regional economic system is presented in a comprehensive and complete manner

Improving the management of the industrial development of the region in the context of the integration of enterprises of petrochemical complex

© 2019, Institute of Advanced Scientific Research, Inc.. All rights reserved. The creation of favorable conditions for the functioning of integrated enterprises, which form industrial-production structures, is one of the priority directions of the state’s activities with the aim of increasing their competitiveness. Along with the extraction of hydrocarbons, the priority is the formation and processing complexes, which planned to produce the entire range of finished petrochemical products (ethylene, propylene, benzene, xylene, butadiene, methanol, rubber products, rubber, etc.). This allowed to significantly the economic efficiency of the industry due to the growth of production. According to experts, to meet global demand in petrochemical products, over 15 years, it will be necessary to build up to 100 large petrochemical plants for the production of ethylene, 400 for the production of plastics and up to 200 for the production of intermediate products. The revenues of the world petrochemical complex today are estimated at 1.6 trillion dollars per year, an increase is expected by 2050 to 15-20 trillion. However, in recent years, the petrochemical industry has accumulated problems related to the uncertainty of raw materials, the complexity of their transportation, the depreciation of fixed assets. Improving the management of the industrial development of the region in the context of the integration of the enterprises of the petrochemical complex is the main solution to the existing problems. Creating the conditions for the production of high-tech products with high added value requires significant changes at the institutional level

Improving the management of the industrial development of the region in the context of the integration of enterprises of petrochemical complex

© 2019, Institute of Advanced Scientific Research, Inc.. All rights reserved. The creation of favorable conditions for the functioning of integrated enterprises, which form industrial-production structures, is one of the priority directions of the state’s activities with the aim of increasing their competitiveness. Along with the extraction of hydrocarbons, the priority is the formation and processing complexes, which planned to produce the entire range of finished petrochemical products (ethylene, propylene, benzene, xylene, butadiene, methanol, rubber products, rubber, etc.). This allowed to significantly the economic efficiency of the industry due to the growth of production. According to experts, to meet global demand in petrochemical products, over 15 years, it will be necessary to build up to 100 large petrochemical plants for the production of ethylene, 400 for the production of plastics and up to 200 for the production of intermediate products. The revenues of the world petrochemical complex today are estimated at 1.6 trillion dollars per year, an increase is expected by 2050 to 15-20 trillion. However, in recent years, the petrochemical industry has accumulated problems related to the uncertainty of raw materials, the complexity of their transportation, the depreciation of fixed assets. Improving the management of the industrial development of the region in the context of the integration of the enterprises of the petrochemical complex is the main solution to the existing problems. Creating the conditions for the production of high-tech products with high added value requires significant changes at the institutional level

Gender-Age Distribution of Patients with COVID-19 at Different Stages of Epidemic in Moscow

The ongoing COVID-19 pandemic around the world and in Russia remains a major event of 2020. All over the world, research is being conducted to comprehensively study the patterns and manifestations of the epidemic  process. The main quantitative characteristics of SARS-CoV-2 transmission dynamics among the population, based on the data of official monitoring over the current situation, play an important role in the development of  the epidemiological surveillance system.The aim of this study is to explore the peculiarities of age-gender distribution of COVID-19 patients in Moscow.Material and methods. The data related to the epidemiological characteristics of age-gender structure of COVID-19 patients in Moscow between March 19, 2020 and April 15, 2020, at different stages of the  epidemic were retrospectively analyzed.Results and discussion. The mean age of COVID-19 patients in Moscow was 46,41±20,58 years. The gender ratio (male/female) among the patients was 52.7/47.3 %, wherein the indicators varied depending upon the  age. Male/female ratio in the age group “under 39” stood at 53.7/46.3 %, and “over 40 years of age” – at  39.3/60.7 %. The predominant age range among male cases was 19 to 39 years old – 35.4 %, while among female patients – 40–59 years (36.5 %). The age distribution of patients in Moscow is indicative of the fact that COVID-19 is a disease that primarily affects older age groups. The age structure of all COVID-19 cases during the observation period is characterized by predominance of adult patients over 19 years of age – 92,7 % (92,6–92,8 %), the share of patients aged 40–59 years is 35,7% (35,5–35,9 %). The differences in the age distribution in males and females are as follows: in the male cohort, the age groups 19–39 years old and 40–59 years old prevail – 35.4 % (35.1–35.7 %) and 34.9 % (34.6–35.2 %), respectively. The age group 40–59 years old – 36.5 % (36.3–36.8%) dominates in the female cohort

Epidemiological significance of detection of SARS-CoV-2 RNA among different groups of population of Moscow and Moscow Region during the COVID-19 outbreak

The Central Research Institute of Epidemiology of Rospotrebnadzor presents priority data obtained from the largescale population PCR-based study of the changes in the rates of circulation of SARS-CoV-2 among relatively healthy residents of Moscow and Moscow Region

Safety and Immunogenicity of Inactivated Whole Virion COVID-19 Vaccine CoviVac in Clinical Trials in 18–60 and 60+ Age Cohorts

We present the results of a randomized, double-blind, placebo-controlled, multi-center clinical trial phase I/II of the tolerability, safety, and immunogenicity of the inactivated whole virion concentrated purified coronavirus vaccine CoviVac in volunteers aged 18–60 and open multi-center comparative phase IIb clinical trial in volunteers aged 60 years and older. The safety of the vaccine was assessed in 400 volunteers in the 18–60 age cohort who received two doses of the vaccine (n = 300) or placebo (n = 100) and in 200 volunteers in 60+ age cohort all of whom received three doses of the vaccine. The studied vaccine has shown good tolerability and safety. No deaths, serious adverse events (AEs), or other significant AEs related to vaccination have been detected. The most common AE in vaccinated participants was pain at the injection site (p p 1:256, the rate of fourfold increase in nAB levels was below 45%; the participants who were seropositive at screening of the 2nd vaccination did not lead to a significant increase in nAB titers. In conclusion, inactivated vaccine CoviVac has shown good tolerability and safety, with over 85% NT seroconversion rates after complete vaccination course in participants who were seronegative at screening in both age groups: 18–60 and 60+. In participants who were seropositive at screening and had nAB titers below 1:256, a single vaccination led to a fourfold increase in nAB levels in 85.2% of cases. These findings indicate that CoviVac can be successfully used both for primary vaccination in a two-dose regimen and for booster vaccination as a single dose in individuals with reduced neutralizing antibody levels