Diabetes mellitus: Complex interplay between metformin, AKI and lactic acidosis.

Debate exists regarding the safety of metformin and the risk of metformin-associated lactic acidosis, particularly in the setting of kidney dysfunction. Data from two studies examining the interplay between metformin, acute kidney injury, and complications including lactic acidosis suggest that metformin should be used conservatively in patients with kidney dysfunction

Observation of a Vector Charmoniumlike State at 4.7 GeV/c2 and Search for Zcs in e+e- →k+K-J/ψ

Using data samples with an integrated luminosity of 5.85 fb-1 collected at center-of-mass energies from 4.61 to 4.95 GeV with the BESIII detector operating at the BEPCII storage ring, we measure the cross section for the process e+e-→K+K-J/ψ. A new resonance with a mass of M=4708-15+17±21 MeV/c2 and a width of Γ=126-23+27±30 MeV is observed in the energy-dependent line shape of the e+e-→K+K-J/ψ cross section with a significance over 5σ. The K+J/ψ system is also investigated to search for charged charmoniumlike states, but no significant Zcs+ states are observed. Upper limits on the Born cross sections for e+e-→K-Zcs(3985)+/K-Zcs(4000)++c.c. with Zcs(3985)±/Zcs(4000)±→K±J/ψ are reported at 90% confidence levels. The ratio of branching fractions {[B(Zcs(3985)+→K+J/ψ)]/B[Zcs(3985)+→(D¯0Ds∗++D¯∗0Ds+)]} is measured to be less than 0.03 at 90% confidence level. © 2023 authors. Published by the American Physical Society

Observation of a Vector Charmoniumlike State at 4.7 GeV/c2 and Search for Zcs in e+e- →k+K-J/ψ

Using data samples with an integrated luminosity of 5.85 fb-1 collected at center-of-mass energies from 4.61 to 4.95 GeV with the BESIII detector operating at the BEPCII storage ring, we measure the cross section for the process e+e-→K+K-J/ψ. A new resonance with a mass of M=4708-15+17±21 MeV/c2 and a width of Γ=126-23+27±30 MeV is observed in the energy-dependent line shape of the e+e-→K+K-J/ψ cross section with a significance over 5σ. The K+J/ψ system is also investigated to search for charged charmoniumlike states, but no significant Zcs+ states are observed. Upper limits on the Born cross sections for e+e-→K-Zcs(3985)+/K-Zcs(4000)++c.c. with Zcs(3985)±/Zcs(4000)±→K±J/ψ are reported at 90% confidence levels. The ratio of branching fractions {[B(Zcs(3985)+→K+J/ψ)]/B[Zcs(3985)+→(D¯0Ds∗++D¯∗0Ds+)]} is measured to be less than 0.03 at 90% confidence level. © 2023 authors. Published by the American Physical Society