PREVALENCE OF NONALCOHOLIC - FATTY LIVER DISEASE IN METABOLIC SYNDROME - A HOSPITAL-BASED CROSS-SECTIONAL STUDY

  Objective: 21st century is dedicated to noncommunicable diseases; it may be diabetes, hypertension, obesity, or constellation of all known as metabolic syndrome. The main objective of this paper is to assess the prevalence of nonalcoholic fatty liver disease (NFLDS) in metabolic syndrome and its impact on the severity of metabolic syndrome in term of dyslipidemia, mean systolic pressure and body mass index (BMI).Methods: A cross-sectional study was conducted on 100 patients selected randomly during the period of January 2017-March 2017 from the outdoor patient department of Kayachikitsa of All India Institute of Ayurveda. Patient included on the basis of a screening pro forma based on the diagnostic criteria of metabolic syndrome on the basis of Third Adult Treatment Panel of the National Cholesterol Education Program criteria and 50 controls were included in the study. Pro forma also included general information regarding previous illness, socioeconomical status, BMI, evaluation of vital parameters, and lipid and thyroid profile, along with other routine laboratory parameters. Ultrasonography report is taken as the evidence for the diagnosis of fatty liver disease.Results: Frequency distributions and Chi-square statistics were used for categorical variables. Logistic regression analyses Students' t-test, Chi-square test, linear regression, and multiple logistic regression models were used for statistical analysis. p<0.05 was considered significant. BMI, waist circumference, mean systolic pressure, diastolic blood pressure, fasting blood sugar, triglycerides, total cholesterol, low-density lipoprotein (LDL) cholesterol were significantly higher, and high-density lipoprotein cholesterol, was significantly low in the study group compared to the control group. In the metabolic syndrome group, 67 patients (67%) had fatty liver Grade I, 34 had Grade II fatty liver (34%), 6 patients were having hepatomegaly with coarse echotexture (6%) and 4 patients were having cholelithiasis. NFLDS was significantly associated with metabolic syndrome group (p<0.0001). There was a significant linear association between fatty infiltration in liver and BMI, total cholesterol, triglycerides, and LDL cholesterol in the metabolic syndrome group in the linear regression model. Multiple logistic regression analysis recognized the association between fatty liver disease and BMI with dyslipidemia (p<0.001) in the metabolic syndrome group.Conclusion: It is concluded from this study that there is a significant association between NFLDS and metabolic syndrome, and it highlights the importance of evaluating liver profile in patients with metabolic syndrome

LOCAL EFFECT OF SARSAPADI TAILA IN THE MANAGEMENT OF UNCOMPLICATED OSTEOARTHRITIS W.S.R TO SANDHIVATA: A PILOT STUDY

Osteoarthritis (degenerative joint disease) is the most common joint disorder and it mostly affects cartilage. Osteoarthritis (OA) is of two types, primary (idiopathic) and secondary. In idiopathic osteoarthritis, the most common form of the disease, no predisposing factor is apparent. Secondary OA is pathologically indistinguishable from idiopathic OA but is attributable to an underlying cause. The NSAIDs are the main drugs of choice in modern medicine which have lots of side effects and therefore are not safe for long-term therapy. According to Ayurveda OA can be correlated with Sandhivata which is mentioned by Acharya Charak as a sign and symptoms of Sandhigatavata are Shula, Shotha, Stambha, Sparsha-asahyata, Sphutana, Akunchana Prasarana Vedana. The aim of the present study was to see the local effect of Sarsapadi Taila, two times in a day for 30 days. Ingredient of Sarsapadi taila is Sarsap taila, Aadrak and Ajwain. The preparation of Taila was done as mentioned in Sharangdhar Samhita. The ratio of the three components is Kalka (AadraK+ Ajwain) one part, Sneha dravya (Sarsap taila) four parts and Drava (water) should be 16 parts. A pilot study was done in All India institute of Ayurveda hospital. In present study total 25 patients were treated with Sarsapadi Taila which was already taking modern analgesics. After the whole study results were analyzed and tapering the analgesic dose of medicine, there was mild significant changes in the condition of the patients. It is advised to Sarsapadi Taila can be used for the treatment of Sandhivata for a long time

Cholesterol & its Ayurvedic Complement – Depicting its role in Pathogenesis as well as Management of Diabetes

Role of cholesterol in the pathogenesis of diabetes is the emergent area of research with full of potential; it not only open a vast area of therapeutic interventions but also can change the prevailing treatment modality. Ayurveda, the Indian system of medicine materialize the concept of lipocenteric approach for the management of diabetes even thousands of years back. According to Ayurveda, the natural properties of lipid are deranged that causes diabetes. It may prove beneficial to quest the search of herbal remedies that can harmonize the lipid balance and uproot the pathogenesis. In the presenting review article, role of cholesterol in the pathogenesis of diabetes is discussed along with detailed description of Ayurvedic concepts regarding pathogenesis and a brief description of herbal management

CLINICAL EVALUATION OF GUGGULU KALPA CHIKITSA IN THE MANAGEMENT OF STHAULYA W.S.R OBESITY- CASE REPORT

Obesity!! When anyone say this word what thought comes to our mind? A fat person with heavy distended abdomen, heavy obese legs, arms, puffy face. But do we think that the person who is obese suffered a lot due his/her weight. This is an era where more than 50% of the human being suffered from this major ailment which actually causes various other diseases like diabetes, hypothyroidism, hypertention, cardiopulmonary diseases. Obesity not only affect the body of a person but it has also a major impact over mind, mostly patient suffered from obesity also suffered with depression because of cutoff and rejection from the society. In Ayurveda also person who is obese/ Sthula is considered under Ninditya purusha which generally means abnormal. Modern medicine has treatment for this but to a very limited extent and it is very costly also. In Ayurveda there is vast reference for Sthaulya and its treatment. Case studies were done on Sthaulya roga in which Guggulu kalpa chikitsa was done and results were evaluated. There was drastic reduction in weight of the patients along with the reduction in inches of abdominal, arm and thigh girth within a month

EVALUATING CLINICAL EFFICACY OF KANTAKARI AEROSOL IN THE MANAGEMENT OF BRONCHITIS: A CASE REPORT

Bronchitis refers to the inflammation of the bronchi and bronchioles, which helps in the movement of the air through the lungs. Bronchitis can be of two types acute and chronic. Acute bronchitis is very common which mainly occurs due to respiratory infections like common cold and chronic bronchitis on the other hand occurs due to the constant irritation which leads to inflammation of the bronchi mainly due to smoking or environment dust and pollution. Major signs and symptoms are dyspnea, cough with sputum. Main risk factors involves smoking, environmental pollution, dust and recurrent lung infections. In Ayurveda it can be correlated with Tamakashwasa on the basis of similar manifestations. Drug delivery mode through nasal route is termed as inhalation therapy; it has various plus points as compare oral drug administration mode. There is an immediate effect, drug goes directly to the site of pathogenesis and quick abruption of the drug. Rasayana therapy is mainly refers to the attainment of the excellence of body fluids, this helps in the rejuvenation of the body and reduce the recurrence of the disease, it also helps in improving the strength and immunity of the body. A case study was done on bronchitis in the All India Institute of Ayurveda hospital. Inhalation therapy was given for 15 days followed by Rasayana therapy for one month. There was marked improvement in all the signs and symptoms of the disease along with increase in pulmonary function test, also there is no recurrence of the signs and symptoms of the disease after the whole course of treatment during follow up

MANAGEMENT OF ACROMEGALY WITH AYURVEDA- A CASE STUDY

Acromegaly is a disease caused by excessive secretion of growth hormone by pituitary gland due to tumour (adenoma). Excessive secretion of growth hormone causes disfigurement and if this affects internal organs it may cause even death. Management of Acromegaly by contemporary medicine is not very successful as surgery (in non- permissible conditions), radiation therapy and use of somatostatin analog, growth hormone antagonist etc., all have limited role and are not able to annihilate the disease. The paper gives the description of a known case of Acromegaly presented with all the cardinal sign and symptoms along with major complications (venous obstruction, loss of peripheral vision, etc.). The patient was taking contemporary medicines from the starting of appearance of sign of disease but didnt get any significant relief therefore he came to seek Ayurvedic treatment. The patient was managed with Ayurvvedic medicines and Panchakarma procedure including Shirodhara for duration of 15 days. Total two sitting of Shirodhara were given one month apart showed considerable improvement in all the presenting symptoms. The increasing sole size, diminished vision and excessive sweating were remarkably reduced with the improvement of overall well being of the patient

CLINICAL EVALUATION OF ERAND MOOLADI BASTI IN THE MANAGEMENT OF GRIDHRASI W.S.R. TO SCIATICA - A CASE STUDY

Background: Large numbers of population suffer from the low back-pain. Prevalence increases linearly from third decade of life on, until the 60 years of age, being more prevalent in woman. Sciatica most commonly occurs when a herniated disk, bone spur on the spine or narrowing of the spine (spinal stenosis) compresses part of the nerve. It is commonly occurs due to the compression of lumbar nerves L4 or L5 or sacral nerves S1, S2 or S3 or by the compression of the sciatic nerve itself. This causes inflammation, pain and often some numbness in the affected leg. Gridhrasi is the one amongst the 80 types of Nanatmaja disorders of Vatavyadhi, It starts from Kati- prishta (pelvic region and Lumbosacral) radiating to Jangha (thigh) and Pada (feet) with impairment of lifting the leg. The gait of the person is very similar to vulture (Gridhra) hence the name is given as Gridharsi. Material and Method: A case controlled clinical study on a known case of Gridharsi has been done in All India Institute of Ayurveda Hospital. The treatment was planned on the basis of principles of Ayurveda mentioned in the context of Gridharsi including Erand-mooladi basti and oral medications. Result: after the whole course of treatment, patient got 70% relief in all sign and symptoms and changes in gait limping gait to normal gait. Conclusion: It can be concluded that Erand-mooladi basti and oral medications is more effective in Gridhrasi management

MANAGEMENT OF BUERGER'S DISEASE THROUGH AYURVEDA- A CASE REPORT

The present case report was about a 50 year-old-male who was diagnosed with Buerger’s disease which is a generalised occlusive vascular diseaseaffecting predominantly males with special predilection to involve the lowerextremities. He presented with complaint of unhealed ulcerations with pain andburning sensation in his right sole for 6 months but not getting satisfactoryrelief even after using conventional medications and advised to get doneamputation. He visited the All India institute of Ayurveda and was treated fortwo months with a combination of Ayurvedic medicines and leech therapy whichshowed significant improvement in patients condition and eventually norecurrence was observed, ulcer healed completely with slight discolouration. Thisshows the effectiveness of Ayurvedic treatment including internal medicinesadministration and leech therapy in preventing amputation and treating othersymptoms which may be useful for clinical practices

Modelling of Tool Life and Micro-Mist flow for Effective Micromachining of 316L Stainless Steel.

Recent technoligical advancement demands new robust micro-components made out of engineering materials. The prevalent methods of manufacturing at micro-nano level are established mostly for silicon structures. Therefore, there is interest to develop technologies for micro-fabrication of non silicon materials. This research studies microend-milling of 316L stainless steel. Machine tool requirement, tool modeling, cutting fluid evaluation, and effect of cutting parameters are investigated. A machine tool with high rigidity, high spindle speed, and minimal runout is selected for successful micro-milling. Cumulative tool wear and tool life of these micro-tools are studied under various cutting conditions. Ideal abrasive wear is observed when applying mist cooling whereas inter-granular shearing is the major failure mode while flood cooling or dry cutting during micro-machining. Various experiments and computational studies suggest an optimal position of the mist nozzle with respect to a tool that provides maximum lubrication at the cutting edge. Mist droplets effectively penetrate the boundary layer of a rotating tool and wet the cutting edge and significantly improve the tool life