27 research outputs found
Individualized conservative therapeutic strategies for adenomyosis with the aim of preserving fertility
Adenomyosis is a diffuse or localized organic disease caused by benign invasion of endometrial glands and stroma into the myometrium. It is a common disease that seriously affects reproductive health of women in childbearing age. Due to the unknown etiology and pathophysiological mechanism, and the lack of unified diagnostic criteria and effective treatment methods, total or subtotal hysterectomy has become a radical treatment for adenomyosis, which will lead to the complete loss of fertility. With the continuous exploration of the treatment to adenomyotic patients who have infertility or fertility intentions, new drugs, surgical methods and treating concepts appears. Adopt individualized conservative therapeutic strategies for patients with different conditions, preserve the uterus as much as possible and protect the patient’s fertility, which will play an important role on the follow-up assisted reproductive treatment and long-term management of adenomyosis
Passive circuit designs toward terahertz using nanometer CMOS technology
This paper presents terahertz passive circuit design and investigation by using a 180 nanometer CMOS technology. A novel multimode bandpass filter and a power divider are designed by adopting a thin-film microstrip line, which uses silicon oxide layer of CMOS as the microstrip substrate. The circuit and fullwave electromagnetic results show that the proposed bandpass filter has a wide passband of 100~150GHz and a return loss of better than 14dB. The designed power divider can operate at 500GHz which is the first reported design using a 180nm CMOS process.Published versio
Direct fabrication of well-aligned free-standing mesoporous carbon nanofiber arrays on silicon substrates
Using nonionic triblock copolymer F127 as a soft template and AAO membranes as hard templates, well-aligned free-standing mesoporous carbon nanofiber arrays have been fabricated on silicon wafer through a confined self-assembly process. Hexagonally arranged circular mesochannels locate at the edge of the carbon nanofibers and some well-ordered columnar oriented mesochannels are wrapped by circular mesochannels at the center of the nanofibers. The surface interaction with the alumina pore walls is probably responsible for the formation of both circular and columnar oriented mesochannels
Virus-Induced Gene Silencing in Rose Flowers
International audienceVirus-induced gene silencing (VIGS) is a favorable method to study gene function by posttranscriptional gene silencing in plants. Here we describe a methodology of graft-accelerated VIGS in rose aimed at obtaining posttranscriptional gene silencing in the flower. The resulting phenotype can be observed within 5-6 weeks post infiltration. By using this method, we successfully silenced the expression of several genes involved in processes such as scent production, petal coloration, or flower architecture. We showed that graft-accelerated VIGS was faster, more efficient, and more convenient than conventional methods previously developed in rose such as agroinfiltration of young plantlets and in vitro cultured tissues or seeds
Direct fabrication of well-aligned free-standing mesoporous carbon nanofiber arrays on silicon substrates
Using nonionic triblock copolymer F127 as a soft template and AAO membranes as hard templates, well-aligned free-standing mesoporous carbon nanofiber arrays have been fabricated on silicon wafer through a confined self-assembly process. Hexagonally arranged circular mesochannels locate at the edge of the carbon nanofibers and some well-ordered columnar oriented mesochannels are wrapped by circular mesochannels at the center of the nanofibers. The surface interaction with the alumina pore walls is probably responsible for the formation of both circular and columnar oriented mesochannels
A low voltage low power highly linear CMOS quadrature mixer using transconductance cancellation technique
This paper presents a low voltage low power high linearity quadrature mixer for software defined radio applications in a 90nm CMOS technology. A 7-dB improvement of input-referred 3rd-order intermodulation point (IIP3) is achieved by using a differential gm″ (the second derivation of transconductance) canceling technology. The negative value of gm″ in saturated pseudo differential transistor (PDT) is compensated by the positive value of PDT in subthreshold region. The even-order distortion is eliminated by differential PDTs. The mixer consumes a dc power of only 3.8mW under 1V supply. The conversion gain with 10 samples is 3.6∼7.2 dB in the frequency range of 0.3∼6 GHz. the IIP3 is 7.9∼12.3 dBm 0.3∼6 GHz, whereas the single-sideband noise figure (SSB NF) is 11.1∼14.7 dB.Accepted versio
ANTP-SMACN7 fusion peptide alone induced high linear energy transfer irradiation radiosensitization in non-small cell lung cancer cell lines.
Objective: The aim of the present study was to investigate the mechanisms responsible for the radiation-sensitizing effect of antennapedia proteins, ANTP-SMACN7, on lung cancer cells treated with accelerated carbon and Fe particle irradiation.Methods: The ANTP-SMACN7 fusion peptide was synthesized and linked to fluorescein isothiocyanate to determine its ability to penetrate cells. A549 and NCI-H460 cells, human non-small cell lung cancer (NSCLC) cell lines, were irradiated with X-ray or high linear energy transfer (LET) irradiation with or without ANTP-SMACN7 treatment. Cellular survival, apoptosis, and protein expression were studied by colony formation assays, flow cytometry, and western blot analyses, respectively.Results: ANTP-SMACN7 fusion proteins entered the cells and promoted A549 and NCI-H460 cell high LET irradiation radiosensitization. High LET irradiation was more efficient for clonogenic cell killing and the induction of apoptosis (P < 0.05). Treatment with ANTP-SMACN7 significantly reduced the A549 and NCI-H460 cell clone-forming percentages and increased apoptosis through inhibition of the X-linked inhibitor of apoptosis protein and the activation of caspase-3 and caspase-9.Conclusions: Regarding pharmaceutical radiosensitization, these findings provided a way to improve high-LET clinical radiotherapy for NSCLC patients.Keywords: Fe-particle radiation; carbon-particle radiation; caspase; non-small cell lung cancer cells; radiosensitizer