Simulation of emission spectra of transition-metal dichalcogenide monolayers with the multimode Brownian oscillator model

The multimode Brownian oscillator model is employed to simulate the emission spectra of transition metal dichalcogenide monolayers. Good agreement is obtained between measured and simulated photoluminescence spectra of WSe2, WS2, MoSe2 and MoS2 at various temperatures. The Huang-Rhys factor extracted from the model can be associated with that from the modified semi-empirical Varshni equation at high temperatures. Individual mechanisms leading to the unique temperature-dependent emission spectra of those TMDs are validated by the MBO fitting, while it is in turn confirmed that the MBO analysis is an effective method for studying the optical properties of TMD monolayers. Parameters extractd from the MBO fitting can be used to explore exciton-photon-phonon dynamics of TMDs in a more comprehensive model

Exciton Dynamics and Time-Resolved Fluorescence in Nanocavity-Integrated Monolayers of Transition-Metal Dichalcogenides

We have developed an ab-initio-based fully-quantum numerically-accurate methodology for the simulation of the exciton dynamics and time- and frequency-resolved fluorescence spectra of the cavity-controlled two-dimensional materials at finite temperature and applied this methodology to the single-layer WSe2 system. This allowed us to establish dynamical and spectroscopic signatures of the polaronic and polaritonic effects as well as uncover their characteristic timescales in the relevant range of temperatures

Cryoballoon vs. laser balloon ablation for atrial fibrillation: a meta-analysis

BackgroundCryoballoon ablation (CBA) and laser balloon ablation (LBA) are two innovative ways for the treatment of atrial fibrillation (AF). This study aimed to evaluate the efficacy and safety of cryoballoon ablation and laser balloon ablation in patients with AF.MethodsWe searched Pubmed, Embase, Ovid, Web of Science and other databases for comparative trials comparing CB and LB ablation in the treatment of AF, from establishment of database to August, 2023.ResultsA total of 13 studies and 3,582 patients were included (CBA, n = 2,308; LBA, n = 1,274). There was no difference between CBA and LBA in acute PVI rate per vein, 12-months recurrence rate of AF, 12-months recurrence rate of atrial arrhythmia, occurrence rate of pericardial tamponade, occurrence rate of inguinal complications. LBA presented a lower acute PVI rate per patients (CBA 97.0% vs. LBA 93.4%, RR = 1.04, 95%CI: 1.01–1.07). Transient nerve palsy was more likely to occur after CBA (CBA 2.7% vs. LBA 0.7%, RR = 4.25, 95%CI: 2.06–8.76). However, the occurrence of persistent nerve palsy between CBA and LBA groups were similar (CB 1.4% vs. LB 1.0%, RR = 1.09, 95%CI: 0.55–2.14). In terms of procedural duration, the procedural time of CBA was shorter than that of LBA (WMD = −26.58, 95%CI: −36.71–16.46).ConclusionsCompared with LBA, CBA had a shorter procedural duration. There was a higher incidence of transient but not persistent phrenic nerve palsy after CBA.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=272607 Identifier (CRD42021272607)

Exploring scale invariance in the expansion of a spherical unitary Fermi gas

A unitary Fermi gas in an isotropic harmonic trap is predicted to show scale and conformal symmetry that have important consequences in its thermodynamic and dynamical properties. By experimentally realizing an isotropic harmonic trap, we study the expansion of a unitary Fermi gas and demonstrate its universal expansion dynamics along different directions and at different temperatures. We show that as a consequence of SO(2,1) symmetry, the measured release energy is equal to that of the trapping energy. In addition, away from resonance when scale invariance is broken, we determine the effective exponent $\gamma$ that relates the chemical potential and average density along the BEC-BCS crossover, which qualitatively agrees with the mean field predictions. This work opens the possibility of studying non-equilibrium dynamics in a conformal invariant system in the future.Comment: 15 pages and 8 figur

Deciphering the role of QPCTL in glioma progression and cancer immunotherapy

BackgroundGlioma is the most lethal and most aggressive brain cancer, and currently there is no effective treatment. Cancer immunotherapy is an advanced therapy by manipulating immune cells to attack cancer cells and it has been studied a lot in glioma treatment. Targeting the immune checkpoint CD47 or blocking the CD47-SIRPα axis can effectively eliminate glioma cancer cells but also brings side effects such as anemia. Glutaminyl-peptide cyclotransferase-like protein (QPCTL) catalyzes the pyroglutamylation of CD47 and is crucial for the binding between CD47 and SIRPα. Further study found that loss of intracellular QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity. However, the role of QPCTL in glioma and the relationship between its expression and clinical outcomes remains unclear. Deciphering the role of QPCTL in glioma will provide a promising therapy for glioma cancer immunotherapy.MethodsQPCTL expression in glioma tissues and normal adjacent tissues was primarily analyzed in The Cancer Genome Atlas (TCGA) database, and further validated in another independent cohort from the Gene Expression Omnibus (GEO) database, Chinese Glioma Genome Atlas (CGGA), and Human Protein Atlas (HPA). The relationships between QPCTL expression and clinicopathologic parameters and overall survival (OS) were assessed using multivariate methods and Kaplan-Meier survival curves. And the proteins network with which QPCTL interacted was built using the online STRING website. Meanwhile, we use Tumor Immune Estimation Resource (TIMER) and Gene Expression Profiling Interactive Analysis (GEPIA) databases to investigate the relationships between QPCTL expression and infiltrated immune cells and their corresponding gene marker sets. We analyzed the Differentially Expressed Genes (DEGs) including GO/KEGG and Gene Set Enrichment Analysis (GSEA) based on QPCTL-high and -low expression tumors.ResultsIn contrast to normal tissue, QPCTL expression was higher in glioma tumor tissue (p ConclusionHigh QPCTL expression predicts high grades of gliomas and poor prognosis with impaired infiltration of adaptive immune cells in the tumor microenvironment as well as higher cancer stemness. Moreover, targeting QPCTL will be a promising immunotherapy in glioma cancer treatment.</p

The global retinoblastoma outcome study : a prospective, cluster-based analysis of 4064 patients from 149 countries

DATA SHARING : The study data will become available online once all analyses are complete.BACKGROUND : Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS : We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS : The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0–36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8–100·0) for children from high-income countries, 91·2% (89·5–93·0) for children from upper-middle-income countries, 80·3% (78·3–82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76–50·00), cT4 advanced tumour compared to cT1 (8·98; 4·44–18·18), and older age at diagnosis in children up to 3 years (1·38 per year; 1·23–1·56). For children aged 3–7 years, the mortality risk decreased slightly (p=0·0104 for the change in slope). INTERPRETATION : This study, estimated to include approximately half of all new retinoblastoma cases worldwide in 2017, shows profound inequity in survival of children depending on the national income level of their country of residence. In high-income countries, death from retinoblastoma is rare, whereas in low-income countries estimated 3-year survival is just over 50%. Although essential treatments are available in nearly all countries, early diagnosis and treatment in low-income countries are key to improving survival outcomes.The Queen Elizabeth Diamond Jubilee Trust and the Wellcome Trust.https://www.thelancet.com/journals/langlo/homeam2023Paediatrics and Child Healt

Analysis on the Propeller Slipstream Interference with Autorotating Rotor Aerodynamic Characteristics

The propeller slipstream passed through the rotor plane when the autogyro is flying forward, will produce the unsteady aerodynamic interference on the autorotating rotor. Based on the RANS equations(Reynolds averaged Navier-Stokes), a computational analysis method for the aerodynamic interference flow field of autorotating rotor-propeller is established by using the moving embedded grids method, and the model is simulated. The unsteady aerodynamic characteristics and flow field characteristics of the isolated and combined autorotating rotor at low speed are analyzed. The effects of different velocities and propeller positions on the aerodynamic characteristics of the spinning rotor are studied. The results show that the propeller slipstream affects the lift-drag characteristics of the autorotating rotor at all azimuths, and causes the distortion of the rotor wake near 0° azimuth. Under the same rotor thrust, the larger the inflow velocity, the smaller the rotor tilt angle, and the smaller the influence of propeller slipstream on the autorotating rotor. Increasing the pitch between the propeller and the autorotating rotor can reduce the aerodynamic interference of the propeller slipstream on the rotor

Experimental study on the thermal performance of a novel physically separated chilled water storage tank

Naturally stratified chilled-water storage is widely used to offset the peak electrical demand caused by airconditioning, but the mixing between cold and warm water greatly influences its thermal performance, especially for a low aspect ratio tank. In this study, a novel physically separated chilled water storage tank is proposed to take place traditional membrane tanks. The thermal performance of this novel tank is evaluated by static and dynamic experiments. The temperature distribution, outlet temperature, figure of merit (FOM1/2/FOM), and percent cold recoverable (PCR) are analyzed when the cold water temperature is approximately 2 degrees C and 4 degrees C, and the temperature difference ranges from 7.91 to 13.86 degrees C. The results demonstrate the excellent thermal performance of the novel tank under a large temperature difference. Compared with conventional temperature conditions, the stability of the outlet temperature under low-temperature conditions is better during the discharging process with the dimensionless temperature increasing by 10% at the end of the process. The full-cycle FOM increases significantly and the PCR decreases slightly with increasing temperature difference. When the FOM reaches its maximum of 93.2%, the PCR exceeds 91%. Therefore, this research work exhibits great application potential of this novel tank due to its ability to improve the thermal performance for a low aspect ratio tank, which provides a new direction for chilled water storage tank design