Respiratory Bronchiolitis-associated Interstitial Lung Disease

We report a case of respiratory bronchiolitis-associated interstitial lung disease (RB-ILD). A 57-year-old man with a 74-pack-year smoking history, had cough, stridor, yellow purulent sputum and general fatigue for several days. The symptoms almost improved after treatment. However, chest computed tomography (CT) showed diffuse centrilobular ground glass opacities although the chest X-ray film showed no obvious opacities. Examination of bronchoalveolar lavage fluid showed relative lymphocytosis. Examination of lung biopsy obtained by video-assisted thoracoscopy allowed the diagnosis of RBILD. The opacities on the CT scan were improved spontaneously without any treatment after cessation of smoking

Bronchiolitis Obliterans Organizing Pneumonia Induced by Minocycline

We report a case of bronchiolitis obliterans organizing pneumonia (BOOP) caused by minocycline (MINO). A 59- year-old man visited to our hospital because of flu-like symptoms. He had been treated with MINO for a few weeks for the skin eruption. The chest radiograph showed consolidations in both lung fields. He was admitted to our hospital for further examination. An elevation of lymphocyte percentage was seen in his bronchoalveolar lavage and a diagnosis of BOOP was confirmed by video-assisted thoracoscopic lung biopsy. The symptoms, laboratory and radiological findings gradually improved without steroid therapy. Although the lymphocyte stimulation test (LST) of peripheral blood for MINO was negative, a positive oral provocation test confirmed the role of MINO in the induction of BOOP

Juvenile Idiopathic Nonspecific Interstitial Pneumonia. and Review of Literature

We describe a case of juvenile idiopathic nonspecific interstitial pneumonia (NSIP). This is the first report of a Japanese patient with idiopathic NSIP aged 27 years. A computed tomographic scan of the chest showed groundglass opacities and reticular opacities in subpleural distribution. Bronchoalveolar lavage fluid revealed no specific finding except for decreased CD4/CD8 ratio of lymphocyte subset. Histopathological features on examination of thoracoscopic lung biopsy specimens were consistent with those of NSIP group III. The patient was treated with corticosteroids and immunosuppressants, but no clinical improvement was noted and the general condition has gradually worsened. Although the prognosis is generally considered to be good in patients with NSIP, some patients die as a result of progression of the disease. The prediction of prognosis based on histopathological, radiologic, and bronchoalveolar lavage cell findings in NSIP seems to be difficult at present

Gastroenteritis Outbreaks Caused by a DS-1–like G1P[8] Rotavirus Strain, Japan, 2012–2013

Rotavirus A (RVA) genotype G1P[8], a hallmark of the Wa-like strain, typically contains only genotype 1 genes. However, an unusual RVA G1P[8] with genotype 2 genes was recently detected in Japan. We determined the complete genomic constellation of this RVA. Our findings suggest that mixed RVAs may be more competitive than once thought

Enterovirus 68 in Children with Acute Respiratory Tract Infections, Osaka, Japan

Enterovirus 68 strains were detected in 14 specimens from children with respiratory tract infections and 1 specimen from a child with febrile convulsions during 2010 in Osaka, Japan. These strains had deletions in the 5′ untranslated region and were genetically different from reported strains. This virus is associated with respiratory tract infections in Japan

Bronchiolitis Obliterans Organizing Pneumonia Induced by Minocycline

We report a case of bronchiolitis obliterans organizing pneumonia (BOOP) caused by minocycline (MINO). A 59- year-old man visited to our hospital because of flu-like symptoms. He had been treated with MINO for a few weeks for the skin eruption. The chest radiograph showed consolidations in both lung fields. He was admitted to our hospital for further examination. An elevation of lymphocyte percentage was seen in his bronchoalveolar lavage and a diagnosis of BOOP was confirmed by video-assisted thoracoscopic lung biopsy. The symptoms, laboratory and radiological findings gradually improved without steroid therapy. Although the lymphocyte stimulation test (LST) of peripheral blood for MINO was negative, a positive oral provocation test confirmed the role of MINO in the induction of BOOP