7 research outputs found
Mesenchymal Stem Cells in a Transgenic Mouse Model of Multiple System Atrophy: Immunomodulation and Neuroprotection
- Author
- A Al Chalabi
- A Giordano
- A Peister
- A Uccelli
- AJ Friedenstein
- Angelika Jamnig
- BC Schaefer
- BI Giasson
- C Krabbe
- CW Shults
- D Offen
- DG Phinney
- DJ Prockop
- EC Hirsch
- GK Wenning
- GK Wenning
- GK Wenning
- GK Wenning
- Gregor K. Wenning
- GĂŒnter Lepperdinger
- HJ Park
- I Amende
- I Kassis
- I Yazawa
- J Sanchez-Ramos
- J Zhao
- K Ishizawa
- KA Jellinger
- M Dominici
- M Kollensperger
- Markus Reindl
- Markus Schuelke
- MF Pittenger
- MF Pittenger
- MG Spillantini
- MI Papp
- MJ West
- N Stefanova
- N Stefanova
- N Stefanova
- N Stefanova
- N Stefanova
- N Stefanova
- Nadia Stefanova
- NK Venkataramana
- P Bossolasco
- PH Lee
- PJ Darlington
- PJ Kahle
- PL Lantos
- RJ Carter
- S Schrepfer
- S Stemberger
- S Theodore
- SW Scholz
- Sylvia Stemberger
- T Ozawa
- TC Moloney
- TM Coyne
- TM Mayhew
- V Brochard
- Y Baba
- YJ Kim
- Z Puschban
- Z Puschban
- Publication venue
- Public Library of Science
- Publication date
- 18/05/2011
- Field of study
Mesenchymal stem cells (MSC) are currently strong candidates for cell-based therapies. They are well known for their differentiation potential and immunoregulatory properties and have been proven to be potentially effective in the treatment of a large variety of diseases, including neurodegenerative disorders. Currently there is no treatment that provides consistent long-term benefits for patients with multiple system atrophy (MSA), a fatal late onset α-synucleinopathy. Principally neuroprotective or regenerative strategies, including cell-based therapies, represent a powerful approach for treating MSA. In this study we investigated the efficacy of intravenously applied MSCs in terms of behavioural improvement, neuroprotection and modulation of neuroinflammation in the (PLP)-αsynuclein (αSYN) MSA model.MSCs were intravenously applied in aged (PLP)-αSYN transgenic mice. Behavioural analyses, defining fine motor coordination and balance capabilities as well as stride length analysis, were performed to measure behavioural outcome. Neuroprotection was assessed by quantifying TH neurons in the substantia nigra pars compacta (SNc). MSC treatment on neuroinflammation was analysed by cytokine measurements (IL-1α, IL-2, IL-4, IL-5, IL-6, IL-10, IL-17, GM-CSF, INFÎł, MCP-1, TGF-ÎČ1, TNF-α) in brain lysates together with immunohistochemistry for T-cells and microglia. Four weeks post MSC treatment we observed neuroprotection in the SNc, as well as downregulation of cytokines involved in neuroinflammation. However, there was no behavioural improvement after MSC application.To our knowledge this is the first experimental approach of MSC treatment in a transgenic MSA mouse model. Our data suggest that intravenously infused MSCs have a potent effect on immunomodulation and neuroprotection. Our data warrant further studies to elucidate the efficacy of systemically administered MSCs in transgenic MSA models
Bataillon, Marcel: Ătudes sur BartolomĂ© de las Casas
- Author
- Publication venue
- Publication date
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- Achs
- Ahmad
- Amerika Im
- Amiama Manuel A.
- Arnaiz Serna
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- Atlantic«
- Ausgabe der Historia In
- Bernlochner
- BrĂŒckner
- BrĂŒckner
- Caballos Mira
- Casas Las
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- Christoffer
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- Cook
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- Cornelissen
- Crosby Alfred
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- CĂłrdova EfrĂn
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- Delgado Mariano
- Denevan William
- der Post Reuter Der
- Dickmann Fritz
- Duffy John
- Ellis Gaynor
- Engstrand Iris
- Erlefried Schröckenfuchs Gerhard Huber
- Es
- Fritsche Fink
- Gesellschaft Wirtschaft
- GrĂŒnder
- Guerra Francisco
- Guerra Francisco
- Guerra Francisco
- Guerra Francisco
- Hanke Lewis
- Hanke Lewis
- Henige David
- Hg William Denevan
- History Virginia Magazine
- Iberoamericana CooperaciĂłn
- Jahrhunderten ĂŒnf
- Johnson Robert
- JubilÀum der Kolumbusfahrt Beitrag
- JuderĂas Julian
- Jun-Hyung
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- Zambardino Rudolph A.
- ĂereuropĂ€ische ĂŒr
- Ăłn
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study
VERZEICHNISSE
- Author
- A.B.
- ABEL
- Abraham ARAZY
- Abraham GEIGER
- Abraham SCHALIT
- Adolf BUECHLER
- Adolf SCHLATTER
- Adolf SCHLATTER
- Aharon OPPENHEIMER
- Ain Fesha VAN DER PLOEG J.
- Albrecht ALT
- Alexander BOEHLIG
- Alf Thomas KRAABEL
- Alfred BERTHOLET
- ALTSHULER D.A.
- ANDERSON
- APPEL
- Arnaldo MOMIGLIANO
- Art ANTOINE P.
- Art ROELLIG W.
- Art SCHMITT H.H.
- ATTRIDGE
- BARTHELEMY D.
- BAYER
- BELLINGER
- Ben-Zion LURIA
- Benedictus NIESE
- Benyamin TSEDAKA
- Bernhard JUSTUS
- Bibliothek der KirchenvÀter EPIPHANIUS VON SALAMIS
- BICKERMAN
- Boaz COHEN
- BRUCE
- BUSINK Th.
- CAMPBELL
- Carsten COLPE
- CODY
- COLLINS
- COWLEY
- CROSS FRANK
- CROWFOOT
- David DAUBE
- David FLUSSER
- Diego ARENHOEVEL
- Dom Hilaire DUESBERG
- Dosithëans KRAUSS S.
- ECKSTEIN
- Elkan-Nathan ADLER
- Emil SCHUERER
- EPIPHANIUS
- Ernest WRIGHT G.
- Ernst BAMMEL
- Ferdinand DEXINGER
- Franz ALTHEIM
- Franz CUMONT
- Friedrich HEYER
- Frédéric MANNS
- GALLING
- Gedalyahu ALON
- Geo WIDENGREN
- Georg FOHRER
- Georg GRAF
- Giorgio JOSSA
- Godfrey Rolles DRIVER
- Gottfried REEG
- GOWAN
- GRAETZ
- GREENWOOD
- GRINTZ
- Guenter MAYER
- Gustaf DALMAN
- Gustav HOELSCHER
- GĂŒnter STEMBERGER
- Hans Gerhard KIPPENBERG
- Hans Heinrich SCHAEDER
- Harald HEGERMANN
- Harald RIESENFELD
- HEIDENHEIM
- Heinz KREISSIG
- Heinz SCHRECKENBERG
- HIGGER
- Hrsg Ă©tiennes
- I.-VII.
- Ida MIEVIS
- Isaiah PRESS
- ISSER
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- James Alan MONTGOMERY
- Jarl FOSSUM
- Jean JUSTER
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- JELLICOE
- Joachim JEREMIAS
- Joel ALONI
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- Joseph AMOUSSINE
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- KAHLE
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- KELVEY
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- Kurt SCHUBERT
- La ZAYADINE F.
- LEIPOLD J. GRUNDMANN
- Leo HAEFELI
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- LĂ©on HERRMANN
- Marcel SIMON
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- Qumran CROSS FRANK M. Jr.
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- RAHLFS
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- RIGSBY
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- ROTHSTEIN
- Rudolf BĂRG
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Abbildungsverzeichnis, Literaturverzeichnis, Register
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- Alchina Franch JosĂ
- Alfonso el Sabio General Estoria
- American Textbook Council
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- Ampelius Lucius
- Angenend Arnold
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- Anglicus Robertus
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- Cassiodorus Magnus Aurelius
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- Comestor Petrus
- Committee on the Study of Teaching Materials on Inter-American Subjects
- Cook
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- Donoso Anes Rafael
- Duffy John
- Duverger Christian
- DĂaz del Castillo Bernal
- Eckel
- Edelmayer Friedrich
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- Efron Noah J
- Eliade
- Eltis David
- Englisch Brigitte
- Engstrand Iris
- Erhardt Alexandra
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- EspaĂol Bouche Luis
- Fazio Mariano
- Fern”ndez Armesto Felipe
- Fern”ndez Retamar Roberto
- Finoccchiaro Maurice
- Flohr Markus
- Folayan Osagie Iyunolu
- Foucault Michel
- Frankl Victor
- Franklin James
- Franzbach Martin
- Garavaglia
- GarcĂa Acosta Virginia
- GarcĂa de la Huerta Izquierdo
- Gautier de ChĂątillon Alexandreis
- Gewecke Frauke
- Gibson Charles
- Gillespie Susan D
- Goebl Ted
- Gonzalez Torres Yolotl
- Grant Edward
- GrĂŒnder Horst
- Guerra Francisco
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- Gvirtz Silvina
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- Hermann der Lahme
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- Heydenreich Titus
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- Holthoff-Stenger Monika
- Horlacher Cornelis
- Horstmann Carl
- Hubert Rainer
- Humboldt
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- Höhne Thomas
- Idrisi Abu
- Iggers Georg
- Irving Washington
- Isidor von Sevilla
- Jacobmeyer Wolfgang
- Jhi Jun-Hyung
- Jones Howard
- Kahle GĂŒnter
- Kelly Louis
- Kirn Paul
- Kleinert Andreas
- Koch Horst
- Kocka JĂŒrgen
- Konetzke Richard
- Konrad von Megenberg
- Krause
- Kriegleder Wynfrid
- Kupperman Karen Ordahl
- Kurscheid Georg
- Kurtz Donald
- König Hans-Joachim
- Lactantius CĂŠlius Firmianus
- Lafaye Jacques
- Lamnek Siegfried
- Landwehr Achim
- Las Casas
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- Matthew
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- McCaa Robert
- McLaughin Mary
- Medina Juan Antonio
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- Menninger Annerose
- MenĂndez Pidal RamĂłn
- Messinger Sandra
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- Poelitz
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- Prause Gerhard
- Prem Hanns
- Prescott William Hickling
- Puetz Wilhelm
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- Quackenbos George Payn
- Radkau GarcĂa Verena
- Ramos PĂrez Demetrio
- Ranke
- Rech Bruno
- Reinhard Wolfgang
- Reinprecht Christoph
- Reiss Wolfram
- Restall Matthew
- Riekenberg Michael
- Ritzelnadel Friedrich August
- Roberts Susan A
- Robicsek Francis
- Rosenblat Angel
- Rosweyde Heribert
- Russell Colin
- Russell Jeffrey Burton
- Russo Lucio
- Rutt John Towill
- RĂ€thzel Nora
- RĂŒsen Jörn
- Sacrobosco Johannes
- Saint-Lu AndrĂ
- Sandberg Brian
- Satjukow Silke
- Scelle Georges
- Scheipl
- Schiller Friedrich
- Schmale Wolfgang
- Schmid Heinz Dieter
- Schmidt Peer
- Schmitthenner
- Schopp Georg Michael
- Schröckenfuchs
- Schröder Susan
- Schuh Adam
- Schulze Schneider Ingrid
- Schulze Winfried
- Schwartz Stuart B
- Scottus Eriugena Johannes
- Seed Patricia
- Senger Hans Gerhard
- Serna Arnaiz Mercedes
- Shackelford Jole
- Shea William
- Simek Rudolf
- Simonyi K”roly
- Sinatra Frank
- Singer Barry
- Sinobas Manuel
- Sint Josef
- SobrequĂs Vidal
- Spiegel Gabrielle Michele
- Spielvogel Jackson J
- Staatengeschichte III
- Stackelberg JĂŒrgen
- Stahel Albert Alexander
- Stahl William
- Stark Rodney
- Stearns Peter N
- Stein Gerd
- Stenzel Werner
- Stoll Eva
- Straub Eberhard
- Straub JĂŒrgen
- Sublimis Deus«
- SĂjournĂ Laurette
- SĂŒtterlin Berthold
- Tatsch
- Teistler Gisela
- Theodosius Macrobius Ambrosius
- Thernstrom Stephan
- Torge Wolfgang
- Townsend Camilla
- Tupetz Theodor
- TĂ€nzler Jade-Yasmin
- Uberti Fazio
- Utzt Susanne
- Vaca de Osma JosĂ Antonio
- Varela Consuelo
- Vaughan Alden T
- Venerabilis Beda
- Verlinden Charles
- Vicente Castro
- Vierhaus Rudolf
- Vogel Klaus Anselm
- Vollet Matthias
- Voltaire
- Von den Brincken Anna-Dorothee
- Weber Bruno
- Weber Georg
- Weissensteiner Fritz
- Wentworth Higgins Thomas
- White Hayden
- Wiater Werner
- Wilson
- Wirth Diane E
- Wirth Fremont Philip
- Wohlfeil Rainer
- Wolf Werner
- Worcester Joseph
- Woynar Karl
- Wright
- Zambardino Rudolph A
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- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study
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- Publication venue
- 'Wiley'
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- Field of study