Phase behaviour of a symmetrical binary fluid mixture

We have investigated the phase behaviour of a symmetrical binary fluid mixture for the situation where the chemical potentials $\mu_1$ and $\mu_2$ of the two species differ. Attention is focused on the set of interparticle interaction strengths for which, when $\mu_1=\mu_2$, the phase diagram exhibits both a liquid-vapor critical point and a tricritical point. The corresponding phase behaviour for the case $\mu_1\ne\mu_2$ is investigated via integral-equation theory calculations within the mean spherical approximation (MSA), and grand canonical Monte Carlo (GCMC) simulations. We find that two possible subtypes of phase behaviour can occur, these being distinguished by the relationship between the critical lines in the full phase diagram in the space of temperature, density, and concentration. We present the detailed form of the phase diagram for both subtypes and compare with the results from GCMC simulations, finding good overall agreement. The scenario via which one subtype evolves into the other, is also studied, revealing interesting features.Comment: 22 pages, 13 figure

Assessment of processing technologies which may improve the nutritional composition of dairy products – Overview of progress

Among consumers there is a growing demand for food products with a natural nutritional-physiological advantage over comparable conventional products. As part of an EU funded project, ALP is examining the possible impact of processing on nutritionally valuable milk components, using the example of conjugated linoleic acids (CLA). The extent to which processing influences the CLA content of the end product was determined by literature research and own investigations of organic and conventional butter. Furthermore, new chemical, sensory-based and bio crystallization methods were evaluated by ALP and the University of Kassel to determine the oxidation stability of butter. In a further step the storage stability of CLA enriched and conventional butter was examined and the different methods will be compared. As a third objective a process for low-input CLA enrichment of milk fat (with a focus on alpine butter) has been developed. Since the process selected for the work is a physical enrichment process, it is accepted by international organic farming and food groups. Among the many benefits ascribed to CLA, it is believed to be an effective agent against cancer. The demand for foods with properties that promote human health is growing. The dairy industry has the opportunity to meet this demand by developing new dairy products with a nutritional-physiological function for the functional food market

Allogeneic hematopoietic cell transplantation as curative therapy for patients with non-Hodgkin lymphoma: Increasingly successful application to older patients

AbstractNon-Hodgkin lymphoma (NHL) constitutes a collection of lymphoproliferative disorders with widely varying biological, histological, and clinical features. For the B cell NHLs, great progress has been made due to the addition of monoclonal antibodies and, more recently, other novel agents including B cell receptor signaling inhibitors, immunomodulatory agents, and proteasome inhibitors. Autologous hematopoietic cell transplantation (auto-HCT) offers the promise of cure or prolonged remission in some NHL patients. For some patients, however, auto-HCT may never be a viable option, whereas in others, the disease may progress despite auto-HCT. In those settings, allogeneic HCT (allo-HCT) offers the potential for cure. Over the past 10 to 15 years, considerable progress has been made in the implementation of allo-HCT, such that this approach now is a highly effective therapy for patients up to (and even beyond) age 75 years. Recent advances in conventional lymphoma therapy, peritransplantation supportive care, patient selection, and donor selection (including the use of alternative hematopoietic cell donors), has allowed broader application of allo-HCT to patients with NHL. As a result, an ever-increasing number of NHL patients over age 60 to 65 years stand to benefit from allo-HCT. In this review, we present data in support of the use of allo-HCT for patients with diffuse large B cell lymphoma, follicular lymphoma, and mantle cell lymphoma. These histologies account for a large majority of allo-HCTs performed for patients over age 60 in the United States. Where possible, we highlight available data in older patients. This body of literature strongly supports the concept that allo-HCT should be offered to fit patients well beyond age 65 and, accordingly, that this treatment should be covered by their insurance carriers

Efficacy of an Online Native Snake Identification Search Engine for Public Use

Visual methods of species identification are used both in research and recreational contexts because they are inexpensive, non-invasive, and believed to be effective among uniquely identifiable individuals. We examined the ability of the general public to identify live snakes (Serpentes) that are native to the United States using an online snake identification search engine (SISE) produced by the North America Brown Tree Snake Control Team (NABTSCT) website, http://www.nabtsct.net. The SISE consisted of participants answering 7 descriptive questions concerning a snake and then reviewing photographs of snakes that matched that description. Using 3 species of snakes native to Texas, USA, 21% of 395 participants were able to correctly identify all of the snakes using the online SISE, 54% correctly identified 2 snakes, 18% correctly identified 1 snake, and only 7% could not identify any snakes. Participants identified the distinctly marked checkered garter snake (Thamnophis marcianus) more readily (87% of participants) than the gopher snake (Pituophis catenifer) and Trans-Pecos rat snake (Bogertophis subocularis; 55% and 46% of participants, respectively). The probability of participants correctly identifying a snake using the online SISE increased substantially if ≥4 of the 7 descriptive questions were answered correctly. The age of participants and affinity toward snakes affected participant ability to correctly answer questions about snake morphology and identify snakes. In general, participants who displayed fear of snakes were less likely to correctly identify snake species than those who expressed a snake-neutral or enthusiast attitude. Additionally, younger participants performed better, on average, than older participants. Most participants (97%) claimed they would be able to use the online SISE to correctly identify other snakes in the future. We believe the public can use the online SISE to identify snakes, and hence, it can be an educational tool for the public to learn about an often neglected wildlife suborder

Determination of astrophysical 12N(p,g)13O reaction rate from the 2H(12N, 13O)n reaction and its astrophysical implications

The evolution of massive stars with very low-metallicities depends critically on the amount of CNO nuclides which they produce. The $^{12}$N($p$,\,$\gamma$)$^{13}$O reaction is an important branching point in the rap-processes, which are believed to be alternative paths to the slow 3$\alpha$ process for producing CNO seed nuclei and thus could change the fate of massive stars. In the present work, the angular distribution of the $^2$H($^{12}$N,\,$^{13}$O)$n$ proton transfer reaction at $E_{\mathrm{c.m.}}$ = 8.4 MeV has been measured for the first time. Based on the Johnson-Soper approach, the square of the asymptotic normalization coefficient (ANC) for the virtual decay of $^{13}$O$_\mathrm{g.s.}$ $\rightarrow$ $^{12}$N + $p$ was extracted to be 3.92 $\pm$ 1.47 fm$^{-1}$ from the measured angular distribution and utilized to compute the direct component in the $^{12}$N($p$,\,$\gamma$)$^{13}$O reaction. The direct astrophysical S-factor at zero energy was then found to be 0.39 $\pm$ 0.15 keV b. By considering the direct capture into the ground state of $^{13}$O, the resonant capture via the first excited state of $^{13}$O and their interference, we determined the total astrophysical S-factors and rates of the $^{12}$N($p$,\,$\gamma$)$^{13}$O reaction. The new rate is two orders of magnitude slower than that from the REACLIB compilation. Our reaction network calculations with the present rate imply that $^{12}$N($p,\,\gamma$)$^{13}$O will only compete successfully with the $\beta^+$ decay of $^{12}$N at higher ($\sim$two orders of magnitude) densities than initially predicted.Comment: 8 figures, 2 tables, Submitted to Physical Review

Investigation of thermonuclear 18^{18}Ne(α\alpha,pp)21^{21}Na rate via resonant elastic scattering of 21^{21}Na+pp

The $^{18}$Ne($\alpha$,$p$)$^{21}$Na reaction is thought to be one of the key breakout reactions from the hot CNO cycles to the rp-process in type I x-ray bursts. In this work, the resonant properties of the compound nucleus $^{22}$Mg have been investigated by measuring the resonant elastic scattering of $^{21}$Na+$p$. An 89 MeV $^{21}$Na radioactive beam delivered from the CNS Radioactive Ion Beam Separator bombarded an 8.8 mg/cm$^2$ thick polyethylene (CH$_{2}$)$_{n}$ target. The $^{21}$Na beam intensity was about 2$\times$10$^{5}$ pps, with a purity of about 70% on target. The recoiled protons were measured at the center-of-mass scattering angles of $\theta_{c.m.}$$\approx$175.2${^\circ}$, 152.2${^\circ}$, and 150.5${^\circ}$ by three sets of $\Delta E$-$E$ telescopes, respectively. The excitation function was obtained with the thick-target method over energies $E_x$($^{22}$Mg)=5.5--9.2 MeV. In total, 23 states above the proton-threshold in $^{22}$Mg were observed, and their resonant parameters were determined via an $R$-matrix analysis of the excitation functions. We have made several new $J^{\pi}$ assignments and confirmed some tentative assignments made in previous work. The thermonuclear $^{18}$Ne($\alpha$,$p$)$^{21}$Na rate has been recalculated based on our recommended spin-parity assignments. The astrophysical impact of our new rate has been investigated through one-zone postprocessing x-ray burst calculations. We find that the $^{18}$Ne($\alpha$,$p$)$^{21}$Na rate significantly affects the peak nuclear energy generation rate, reaction fluxes, as well as the onset temperature of this breakout reaction in these astrophysical phenomena