8 research outputs found
Matrix metalloproteinases in squamous cell carcinoma
No full textControlled degradation of extracellular
matrix (ECM) is essential in many physiological
situations including developmental tissue remodeling,
angiogenesis, tissue repair, and normal turnover of
ECM. In addition, degradation of matrix components is
an important feature of tumor growth, invasion,
metastasis, and tumor-induced angiogenesis. Matrix
metallo-proteinases (MMPs) are a family of zincdependent
neutral endopeptidases, which are collectively
capable of degrading essentially all ECM components.
MMPs apparently play an important role in all the above
mentioned aspects of tumor development. In addition,
there is recent evidence that MMP activity is required
for tumor cell survival. At present, several MMP
inhibitors are in clinical trials of malignant tumors of
different histogenetic origin. In this review we discuss
the current view on the role of MMPs and their
inhibitors in development and invasion of squamous cell
carcinomas, as a basis for prognostication and
therapeutic intervention in these tumors
Adenovirus-Mediated Transfer and Overexpression of Heme Oxygenase 1 cDNA in Lungs Attenuates Elastase-Induced Pulmonary Emphysema in Mice
No full textTumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma
No full textDermatology-oncolog
Promoting Tropoelastin Expression in Arterial and Venous Vascular Smooth Muscle Cells and Fibroblasts for Vascular Tissue Engineering
No full textTransforming Growth Factor Beta 1 and Hyaluronan Oligomers Synergistically Enhance Elastin Matrix Regeneration by Vascular Smooth Muscle Cells
No full textDeficiencies of fibrillin and decorin in fibroblast cultures of a patient with neonatal Marfan syndrome.
No full text
