Adenoviral targeting of malignant melanoma for fluorescence-guided surgery prevents recurrence in orthotopic nude-mouse models.

Malignant melanoma requires precise resection in order to avoid metastatic recurrence. We report here that the telomerase-dependent, green fluorescent protein (GFP)-containing adenovirus OBP-401 could label malignant melanoma with GFP in situ in orthotopic mouse models. OBP-401-based fluorescence-guided surgery (FGS) resulted in the complete resection of malignant melanoma in the orthotopic models, where conventional bright-light surgery (BLS) could not. High-dose administration of OBP-401 enabled FGS without residual cancer cells or recurrence, due to its dual effect of cancer-cell labeling with GFP and killing

Fetal Outcomes among Grand Multiparous and Multiparous Women in Mulago Hospital, Uganda

Objective: To compare fetal outcomes among grand multiparous (para 5-9) and multiparous (para 2-4) delivering in Mulago hospital, Uganda.Design: Prospective cohort study.Setting: Mulago hospital, Uganda.Subjects: One hundred and fifty six grand multiparous and multiparous women were recruited on admission in labour ward and followed up through labour and immediate post partum period. Fetal outcomes among the two groups were collected and analyzed.Results: The admissions to SCU were similar in the two groups i.e. 11(7%) GMP vs. 11(7%) MP, the number of fresh still births was higher among the grandmultiparas 13(8.3%) GMP vs. 7(4.5%) MP though this was not statistically significant. The fetal weight did not significantly differ in the two groups.Conclusion: There was no difference in fetal outcomes among GMPs when compared to MPs.Key words: Grand multiparous (GMP), Multiparous (MP), Birth weight,  Special Care Unit (SCU), Apgar score, Fresh Still Birth (FSB)

Scalable Spin Amplification with a Gain over a Hundred

We propose a scalable and practical implementation of spin amplification which does not require individual addressing nor a specially tailored spin network. We have demonstrated a gain of 140 in a solid-state nuclear spin system of which the spin polarization has been increased to 0.12 using dynamic nuclear polarization with photoexcited triplet electron spins. Spin amplification scalable to a higher gain opens the door to the single spin measurement for a readout of quantum computers as well as practical applications of nuclear magnetic resonance (NMR) spectroscopy to infinitesimal samples which have been concealed by thermal noise.Comment: 6 pages, 7 figure