32 research outputs found
Komatiit in der mineralogisch-petrographischen Sammlung der Sektion Geographie der Martin-Luther-Universität Halle-Wittenberg
Zur Geschichte der Mineralogie an der Martin-Luther-Universität Halle-Wittenberg in der I. Hälfte des 20. Jahrhunderts
Mitteilungen aus dem Institut: Nachrufe
Hans Jürgen Rösler, *14. Mai 1920 - †12. Januar 2009,in memoriam
Günter Zinke, *8. Mai 1940 - †27. Mai 2010, in memoria
Transdermal wires for improved integration in vivo.
Alternative engineering approaches have led the design of implants with controlled physical features to minimize adverse effects in biological tissues. Similar efforts have focused on optimizing the design features of percutaneous VAD drivelines with the aim to prevent infection, omitting however a thorough look on the implant-skin interactions that govern local tissue reactions. Here, we utilized an integrated approach for the biophysical modification of transdermal implants and their evaluation by chronic sheep implantation in comparison to the standard of care VAD drivelines. We developed a novel method for the transfer of breath topographical features on thin wires with modular size. We examined the impact of implant's diameter, surface topography, and chemistry on macroscopic, histological, and physical markers of inflammation, fibrosis, and mechanical adhesion. All implants demonstrated infection-free performance. The fibrotic response was enhanced by the increasing diameter of implants but not influenced by their surface properties. The implants of small diameter promoted mild inflammatory responses with improved mechanical adhesion and restricted epidermal downgrowth, in both silicone and polyurethane coated transdermal wires. On the contrary, the VAD drivelines with larger diameter triggered severe inflammatory reactions with frequent epidermal downgrowth. We validated these effects by quantifying the infiltration of macrophages and the level of vascularization in the fibrotic zone, highlighting the critical role of size reduction for the benign integration of transdermal implants with skin. This insight on how the biophysical properties of implants impact local tissue reactions could enable new solutions on the transdermal transmission of power, signal, and mass in a broad range of medical devices