Short-Term Variability of PKS1510-089

We searched a short-term radio variability in an active galactic nucleus PKS 1510-089. A daily flux monitoring for 143 days at 8.4 GHz was performed, and VLBI observations at 8.4, 22, and 43 GHz were carried out 4 times during the flux monitoring period. As a result, variability with time scale of 20 to 30 days was detected. The variation patterns were well alike on three frequencies, moreover those at 22 and 43 GHz were synchronized. These properties support that this short-term variability is an intrinsic one. The Doppler factor estimated from the variability time scale is 47. Since the Doppler factor is not extraordinary large for AGN, such intrinsic variability with time scale less than 30 days would exist in other AGNs.Comment: 14 pages, 4 figure

Multi-Wavelength Photometric and Polarimetric Observations of the Outburst of 3C 454.3 in Dec. 2009

In December 2009, the bright blazar, 3C 454.3 exhibited a strong outburst in the optical, X-ray and gamma-ray regions. We performed photometric and polarimetric monitoring of this outburst in the optical and near-infrared bands with TRISPEC and HOWPol attached to the Kanata telescope. We also observed this outburst in the infrared band with AKARI, and the radio band with the 32-m radio telescope of Yamaguchi University. The object was in an active state from JD 2455055 to 2455159. It was 1.3 mag brighter than its quiescent state before JD 2455055 in the optical band. After the end of the active state in JD 2455159, a prominent outburst was observed in all wavelengths. The outburst continued for two months. Our optical and nearinfrared polarimetric observations revealed that the position angle of the polarization (PA) apparently rotated clockwise by 240 degrees within 11 d in the active state (JD 2455063-2455074), and after this rotation, PA remained almost constant during our monitoring. In the outburst state, PA smoothly rotated counterclockwise by 350 degrees within 35 d (JD 2455157-2455192). Thus, we detected two distinct rotation events of polarization vector in opposite directions. We discuss these two events compared with the past rotation events observed in 2005, 2007 and 2008.Comment: 9 pages, 6 figures, accepted for publication in PAS

Effect of diabetes and prediabetes on the development of disability and mortality among middle-aged Japanese adults : A 22-year follow up of NIPPON DATA90.

Aims/introduction:To examine the association between diabetes and prediabetes at baseline, and disability, mortality over a 22-year period among middle-aged Japanese adults.Materials and methods:Participants consisted of 1,788 adults aged 45-64 years at baseline from the cohort study National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 1990 (NIPPON DATA90). Disability, defined as having a decline in activities of daily living (ADL), was assessed by a modified Katz questionnaire at four time points. Disability and death without disability for 22-year follow up were used as outcomes to test the association with a diagnosis of diabetes or prediabetes at baseline, using multinomial logistic regression. Adjusted odds ratios (ORs) were obtained from four models that contained appropriate adjustment factors, such as age, sex, smoking status, drinking status, body mass index and cardiovascular risk factors (hypertension, hypercholesterolemia, triglycerides, low serum high-density lipoprotein), at baseline.Results:In the present study, 334 participants (18.7%) reported at least one disability, and 350 (19.6%) were reported dead without observation of disability during follow up. Adjusting sex and other risk factors, participants with diabetes and prediabetes had a higher risk for disability (OR 1.43, 95% confidence interval [CI] 1.07-1.91 and OR 1.66, 95% CI 1.10-2.50, respectively) and for mortality (OR 1.56, 95% CI 1.16-2.08 and OR 1.77, 95% CI 1.18-2.65, respectively) than individuals with normal glucose tolerance.Conclusions:In middle-aged Japanese adults, individuals with diabetes and prediabetes were more likely to be associated with disability and mortality. Our findings suggest that prediabetes and diabetes in middle-aged adults should be paid more attention, and requires more intervention to prevent disability and mortality in later life

Efficacy and safety of concurrent anti-Cancer and anti-tuberculosis chemotherapy in Cancer patients with active Mycobacterium tuberculosis: a retrospective study

Abstract Background In our previous study, colorectal cancer (CRC) patients with active Mycobacterium tuberculosis (MTB) tolerated concurrent anti-cancer chemotherapy (anti-CCT) and anti-MTB chemotherapy. In this study, we retrospectively confirmed the efficacy and safety of concurrent chemotherapy in a greater number of patients with different types of malignancies. Methods We enrolled 30 patients who were treated concurrently with anti-CCT and anti-MTB regimens between January 2006 and February 2016. Cancer and MTB treatments were administered according to the approved guidelines. Results Patient demographics included: men/woman: 24/6; median age: 66.5 years; Eastern Cooperative Oncology Group performance status 0–1/2/3–4: 24/4/2; Stage IIB–IIIC/IV/recurrence: 6/22/2; lung cancer (LC)/CRC/other: 15/10/5; and MTB diagnosis (before or during anti-CCT): 20/10 (LC: 8/7; CRC: 8/2; other: 4/1). For anti-CCT, 23 patients received two cytotoxic agents with or without targeted agents and 7 patients received a single cytotoxic or targeted agent. The overall response rate was 36.7%. Regarding anti-MTB chemotherapy, 22 patients received a daily drug combination containing isoniazid, rifampicin, and ethambutol, plus pyrazinamide in 15 of the 22 patients, followed by daily isoniazid and rifampicin; the remaining 8 patients received other combinations. Hematological adverse events of Grade ≥ 3 were observed in 19 (67.9%) of 28 patients; laboratory data were lost for the remaining 2. Grade 3 lymphopenia and higher were significantly more frequent in LC compared to other malignancies (P < 0.005). Non-hematological adverse events of Grade ≥ 3 were observed in 5 (16.7%) of 30 patients. One CRC patient experienced Grade 3 hemoptysis and another 2 experienced Grade 3 anaphylaxis. One patient with cholangiocellular carcinoma and gastric cancer experienced Grade 3 pseudomembranous colitis as a result of a Clostridium difficile infection. One patient (3.3%) died of pemetrexed-induced pneumonitis. The success of the anti-MTB chemotherapy was 70.0%. There were no MTB-related treatment failures. The median overall survival (months, 95.0% confidence interval) was 10.5 (8.7–36.7), 8.7 (4.7–10.0), 36.7 (minimum 2.2), and 14.4 (minimum 9.6) for all patients combined, LC, CRC, and Other malignancies, respectively. LC patients experienced delayed MTB diagnosis and shorter overall survival. Conclusions Concurrent chemotherapy is effective and safe for treating cancer patients with active MTB