Very High Energy Gamma Rays from PSR1706-44

We have obtained evidence of gamma-ray emission above 1 TeV from PSR1706-44, using a ground-based telescope of the atmospheric \v{C}erenkov imaging type located near Woomera, South Australia. This object, a $\gamma$-ray source discovered by the COS B satellite (2CG342-02), was identified with the radio pulsar through the discovery of a 102 ms pulsed signal with the EGRET instrument of the Compton Gamma Ray Observatory. The flux of the present observation above a threshold of 1 TeV is $\bf \sim$ 1 $\cdot$ 10$^{-11}$ photons cm$^{-2}$ s$^{-1}$, which is two orders of magnitude smaller than the extrapolation from GeV energies. The analysis is not restricted to a search for emission modulated with the 102 ms period, and the reported flux is for all $\gamma$-rays from PSR1706-44, pulsed and unpulsed. The energy output in the TeV region corresponds to about 10$^{-3}$ of the spin down energy loss rate of the neutron star.Comment: 13 pages, latex format (article), 2 figures include

Sharp weighted bounds for fractional integral operators

The relationship between the operator norms of fractional integral operators acting on weighted Lebesgue spaces and the constant of the weights is investigated. Sharp bounds are obtained for both the fractional integral operators and the associated fractional maximal functions. As an application improved Sobolev inequalities are obtained. Some of the techniques used include a sharp off-diagonal version of the extrapolation theorem of Rubio de Francia and characterizations of two-weight norm inequalities

Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states.

Whilst the brain is assumed to exert homeostatic functions to keep the cellular energy status constant under physiological conditions, this has not been experimentally proven. Here, we conducted in vivo optical recordings of intracellular concentration of adenosine 5’-triphosphate (ATP), the major cellular energy metabolite, using a genetically encoded sensor in the mouse brain. We demonstrate that intracellular ATP levels in cortical excitatory neurons fluctuate in a cortex-wide manner depending on the sleep-wake states, correlating with arousal. Interestingly, ATP levels profoundly decreased during rapid eye movement sleep, suggesting a negative energy balance in neurons despite a simultaneous increase in cerebral hemodynamics for energy supply. The reduction in intracellular ATP was also observed in response to local electrical stimulation for neuronal activation, whereas the hemodynamics were simultaneously enhanced. These observations indicate that cerebral energy metabolism may not always meet neuronal energy demands, consequently resulting in physiological fluctuations of intracellular ATP levels in neurons

Improved measurement of the K+->pi+nu(nu)over-bar branching ratio

An additional event near the upper kinematic limit for K+-->pi(+)nu(nu) over bar has been observed by experiment E949 at Brookhaven National Laboratory. Combining previously reported and new data, the branching ratio is B(K+-->pi(+)nu(nu) over bar)=(1.47(-0.89)(+1.30))x10(-10) based on three events observed in the pion momentum region 211<P<229 MeV/c. At the measured central value of the branching ratio, the additional event had a signal-to-background ratio of 0.9